<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25485

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEQTGSLMLPLRPQTTKTSKKDNLPIRIAQINAQRGSFRNITEQSLQDEIKAQKERSKDKLEEEEEESKSQENVNEVDATERQELLYKRRAEIIQFAAQAHMETQFALDFISLLLSKHAPRQAETSISPYLKQNVPMGSLNIDVVKAPPKSQTALRDTQNVAHGWKIESFNASANRLLKAASRLESEVAAETKYWDQVLSIKDKGWKVCRLPRERQVLGVQYGFMEAAPTFRDRGLASLRRADDGTLVLDKGLVPSRARAVRVRVKKQGKITGSSSLSRFVAAAVSDDSVEKTILQSRDTLFEEELFHELTREARVLVSSGVTAHKDLIEFEYEAGEQILLELADVDDNPENDSEPSEGSTVNNNEAEAIAYALRILLSYAHRQNLRRRSQFPPPLTNQKRPTPQYQLLRPILSYMQHDAHVRSLQSFLQDVYQVLNSAGLASKYTTSKFSSLQFKSSADVSSSTSVETLLSQFMEPLESRFSGSMANPTSTYNIRIHTTMPDTSSRQMALGTDYELTIRLPNYPYTQPPSRIGLKHEVELLLLRLFTLDLITYISSISSHNAAAARGGDFTKNLLLWESPFPHHGELSGVTQDGKAVKQLAINLSRDSLGLCLKSRSQHDDKSDTNETAKKEDEAIDHDEDPFQSEFVVGPGGLQYTRPPQRLAGGEVVHVWRREDVKGAPKTLAEVIRDISSI
Length695
PositionHead
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.06
Grand average of hydropathy-0.557
Instability index53.67
Isoelectric point6.30
Molecular weight78004.83
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25485
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     238.55|      76|     128|     455|     533|       1
---------------------------------------------------------------------------
  455-  533 (122.01/80.12)	FKSSADVSSSTSVETLLSQFMEPLeSRFS.GSMANPTSTYNIRIHTTmpDTSSRQ.MALGTD.....YELTIRLPNYPYTQPPSRI
  582-  664 (116.54/66.76)	FPHHGELSGVTQDGKAVKQLAINL.SRDSlGLCLKSRSQHDDKSDTN..ETAKKEdEAIDHDedpfqSEFVVGPGGLQYTRPPQRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.46|      56|     128|       5|      74|       2
---------------------------------------------------------------------------
    5-   74 (67.44/75.52)	GSLMLplrpQTTKTSKKDNLPIRIAQiNAQRG....SFrNITEQSLqdeIKAqkersKDKLEEE.EEESKSQENV
  138-  198 (85.02/51.82)	GSLNI....DVVKAPPKSQTALRDTQ.NVAHGwkieSF.NASANRL...LKA.....ASRLESEvAAETKYWDQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.58|      29|      34|     356|     387|       3
---------------------------------------------------------------------------
  356-  387 (43.21/36.21)	PsegSTVNNNEAEAIAYA.LRILLSY.AHRQNLR
  393-  423 (44.37/28.46)	P...PPLTNQKRPTPQYQlLRPILSYmQHDAHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.72|      10|      27|     547|     556|       7
---------------------------------------------------------------------------
  547-  556 (17.33/ 8.16)	FTLDLITYIS
  571-  580 (18.38/ 8.97)	FTKNLLLWES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25485 with Med17 domain of Kingdom Fungi
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