<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25484

Description "RNA polymerase II mediator complex component Srb8, putative"
SequenceMIPHPSSTGFQTWTNHTHASDRSSMAVAPAPSSAQQIIDLSASDGGPSETEHLHKRPRLDTTVSGLASDGRTPSRSADARSATTLASGGSNPTRPAVVSGRGRPAYSFQDLVADTYGASVFGNTTPGSQPAKPPSPPPFPVRPWTHTPARQSHIENEGLSDNLRSREVQTIPYHPETPEVAPILTREKVADYSPWSRLGNHPEDRLSDLNVRAGNFERAPGVNTNSDIQSHASKLSGQLKSHSSLQLLSSVFAAALEKRQINEKISSSSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSQGLETKWVREWTLSVQQFTAGVISACGKPDWRNKMTYAVRLAARLFYEHLLDQDYYLDWYLSSMENSSLDAFPIWLAMLNIYWGSLVRFRKRGRRLAEALLEKLRDATFSDFKVHLQPLVDRVSLLVRRLCREHSPCLILPRSWDRYQDVVAASLSSGDTKEKAILQSLVLRNARVQRPGTYCPVRQRSPQEQVIKLLDASRDTCDMCALSGRCLALVPDRQDLVSVLLRWAASPFRQGLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQTSTEQSASMANVYHIIVELIRSQTFSVGRYLQWLVARGAVEQYRQHNPAEESPSSVPVDIALLSHIPVARLPRHLRNLRDTLLARAGLSSSENEVLRSIKADLKQRLPGLFGKDDSHMSLNYDKDNLSWSVKADISQWVRAAVSEHYESGSAYSQKMYESSVEASSLTQEEFLVVRSILEQYGDLSMLADILIDASNSDDVRLLTCAVDTLNRHFECFTIIGALGDMFRSFYEAFLRVKNSGQPLYDLAYSMAEVGHRLPNEVNSLILLRQELSRADRNLALAACSPVSDMAETLNDASPSFNEDMDQFLSSGNSMDEMTMILVFQKLIQQLAFYDEKDPSMPGTVCRHLVQLRSFNSKHFDLLLVQWLEKTLKSTSRPNLSRLLYPLVGIGCVTLPAFATLTKKVLHSGSLQTDAFALPDWLVDFLNLLVPKYSAEPLYDFLAYRFRIAQEEFLHGHSNEVLALLKDAVPYMTVNTAQEIAPLAPCVVPLLSEIIVRHPEDTTMDSLRGLIKTCPRFLPVVRQSLDLLLNDNEQSNSDFLLKTAATITQTNHLSLPLCQMKLQILFDEKNDESMRNSIVDLMYKSAVADVRTGNTYWLDLVSTMGQEAAEHLRQRAEKDFFSITQSDIALEKDSENERLALQEDARVYLSIVDGLAYSIPEEGVSSIAPILVEKMNALLQRLFTMHMNVRNWSEHRSRSSQEAITRQLSGCEENFVFWLTAMLQMIRIHRAAFDVPAMSGNQRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQNCANFIKDRFPPALNVQNDPRLQYLFGPVAENSGNPGGPLPSSGPVSSPAATTLTPSTNPVNNTAGTAGGNTIEDPMAIHNRLRVQSHGRVIGSYPLRPWEMLEEAAPVVGANDTAIDLNLFGARKVREY
Length1571
PositionKinase
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.242
Instability index50.27
Isoelectric point7.39
Molecular weight175026.24
Publications
PubMed=25676766

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25484
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1287.75|     364|     386|     697|    1080|       1
---------------------------------------------------------------------------
  384-  697 (312.01/234.92)	......................................................WRNK........MTYAVRLAARLFYEHllDQDYYLDWYLSSMENSSL..DAFPI.WLAMLNIYwGSLvrfrkrgR.....RLAEALLE.......KLRDATFS...........DFKVHL................................QPLVD...RVSLLVRRLCREhspclilprswdryqdvvaaslssgdtkekaiLQSLVLRNARVQRPGTYCPVRQRSPQEQVIKLL.DAS...RDTCDMCAL................SGRC...LALVPDRQDLVSVLLRW.AASPFRQGLV.RVYIAVRLFrkwkrSGMDIDACIFPFLTQtsTEQSASMANVYHIIVELI....................................RS.....QTFSVGrylQWLV..........argaveqyrqhnpaeespSSVPVDIALLSHIPVAR...LPRH
  698- 1081 (566.19/501.71)	LRNLRDTLLARAGLSSSENEVLRSIKADLkqrLPGLFGKDDSHMSLnydkDNLSWSVKA......DISQWVRAAVSEHYES..GSAYSQKMYESSVEASSLtqEEFLV.VRSILEQY.GDL.......S.....MLADILIDASNSDDVRLLTCAVD...........TLNRHFecFTIIGALG....DMFRSFYEA.FLRVKNSgQPLYDLAYSMAEVGHRLPNE................................VNSLILLRQELSRADRNLALAACSPVSDMAETLNDASPSFNEDMDQFLS................SGNSMDEMTMILVFQKLIQQLAFYDEKDPSMPGTVcRHLVQLRSF.....NSKHFDLLLVQWLEK..TLKSTSRPNLSRLLYPLVGIGCVTLPA..................FATLTKKVLHSGSLQTDAFALP...DWLVDFLnllvPKY..................SAEPLYDFLAYRFRIAQeefLHGH
 1086- 1451 (409.55/313.59)	LALLKDAVPYMTVNTAQEIAPLAPCVVPL...LSEIIVRHPEDTTM....DSLRGLIKTcprflpVVRQSLDLLLNDNEQS..NS...................DFLLkTAATITQT.NHL.......SlplcqMKLQILFDEKNDESMR..NSIVDlmyksavadvrTGNTYW..LDLVSTMGqeaaEHLRQRAEKdFFSITQS.....DIALEKDSENERLA.........................................LQEDARV..YLSIVDGLAYSIPEEGVSSIAPILVEKMNALLQrlftmhmnvrnwsehrSRSSQEAITRQL..SGCEENFVFWLTA...........MLQMIRI.....HRAAFD...VPAMSG..NQRLGAYVDLSRL...LIIICCLALSRtplgltvqprldlsassyFLASAKEVRAGNTIQTYALDIA...SSLVDSL....PDE..................ARQNCANFIKDRF...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.94|      26|      33|      57|      82|       2
---------------------------------------------------------------------------
   57-   76 (28.81/10.73)	...............PRLDTT.VSGLASDGRTPSRS
   77-  107 (33.69/13.61)	ADARSAttlasggsnPTRPAV.VSG...RGR.PAYS
  113-  132 (26.44/ 9.33)	ADTYGA...............sVFGNTTPGSQPAK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.72|      16|     133|       3|      19|       3
---------------------------------------------------------------------------
    3-   18 (33.14/24.66)	PHPSSTGFQTWTNHTH
   39-   54 (28.58/14.60)	DLSASDGGPSETEHLH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25484 with Med12 domain of Kingdom Fungi
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