<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25473

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMKDLKELKHWIDKTHLDFQVELEMNAQLSSALDGLENKLNSLLTSLTTPAAVGAPAAATALLESDDVISSALDTLRMHQANYAKVLHLRSEAYNLEERIQTIVRDISGAGKEIAQATGDDDDDDYEIDTENDDDDDESETDRESENTESITQQQKKSKKGRRKEVDYKLLLEFARRISKYNAQAAADATTGVMGTNGSTTKKLQRKQSEDAKMIDANGLDATIDRQQQNGEQEVTVGTVTKEATSWLEESADADRQSFMIPYPNEDRIRMGLMGQLQLAAVDGNIDPEKEAERLVQEAEGISGGVASGLGDAQARPEALAEEAGKAAMNAGARDATRPSARGAPPPAQPRPALNLDLYDPEDDD
Length364
PositionMiddle
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.03
Grand average of hydropathy-0.778
Instability index39.64
Isoelectric point4.46
Molecular weight39676.06
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25473
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.04|      28|      31|     209|     237|       1
---------------------------------------------------------------------------
  187-  204 (19.14/ 6.49)	...........DATTGVMG....TNGSTTKKLQ
  209-  237 (41.92/25.87)	EDAKMIDANGlDATIDRQQ....QNGEQEVTVG
  242-  271 (37.99/19.31)	EATSWLEESA.DA..DRQSfmipYPNEDRIRMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.14|      14|      39|      22|      35|       2
---------------------------------------------------------------------------
   22-   35 (24.49/13.77)	LEMNAQLSSALDGL
   62-   75 (23.65/13.09)	LESDDVISSALDTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25473 with Med4 domain of Kingdom Fungi
Unable to open file!