Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MKDLKELKHWIDKTHLDFQVELEMNAQLSSALDGLENKLNSLLTSLTTPAAVGAPAAATALLESDDVISSALDTLRMHQANYAKVLHLRSEAYNLEERIQTIVRDISGAGKEIAQATGDDDDDDYEIDTENDDDDDESETDRESENTESITQQQKKSKKGRRKEVDYKLLLEFARRISKYNAQAAADATTGVMGTNGSTTKKLQRKQSEDAKMIDANGLDATIDRQQQNGEQEVTVGTVTKEATSWLEESADADRQSFMIPYPNEDRIRMGLMGQLQLAAVDGNIDPEKEAERLVQEAEGISGGVASGLGDAQARPEALAEEAGKAAMNAGARDATRPSARGAPPPAQPRPALNLDLYDPEDDD |
Length | 364 |
Position | Middle |
Organism | Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.778 |
Instability index | 39.64 |
Isoelectric point | 4.46 |
Molecular weight | 39676.06 |
Publications | PubMed=25676766 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25473 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 99.04| 28| 31| 209| 237| 1 --------------------------------------------------------------------------- 187- 204 (19.14/ 6.49) ...........DATTGVMG....TNGSTTKKLQ 209- 237 (41.92/25.87) EDAKMIDANGlDATIDRQQ....QNGEQEVTVG 242- 271 (37.99/19.31) EATSWLEESA.DA..DRQSfmipYPNEDRIRMG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.14| 14| 39| 22| 35| 2 --------------------------------------------------------------------------- 22- 35 (24.49/13.77) LEMNAQLSSALDGL 62- 75 (23.65/13.09) LESDDVISSALDTL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AEEAGKAAMNAGARDATRP 2) RPALNLDLYDPEDDD 3) YKLLLEFARRISKY | 320 350 167 | 338 364 180 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab