<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25472

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGDATTNFIAINGFSVIHWRIYTEEATTNNPSSEIAPSSGYNILRHLSRLKDLEIQLRNLDCLVSCYPRRLGLWVFSPTPGFESLSPLTRDAAPPTLKESKLSIGASSLKVSAFGSISAADLIKSLSGDGVTAAAGTPGQPGRTPGSAVNVPRSGDAYANSMAIYASFITAIAGAISLQLIRRHNAIPLGSRTFYTAVERSFYENPTISDDDVDWIRTLTTLRIELTQVGKIVLALHTIHQDGISRLREPNRTDITPSNIQPNMDVWLAPNGTVARLINVNTAQSAVFAPKQAKSEGVSRQITEAKQRVWKETVLEWLSNLGLPVDHPKDEHWVEVEVSEPFYARLAAEHLRQMDDSQSSSPLKRILWPSRYCFWRTKMASSEKVCELNDGEEPLHFAETWLETATSRHEKPNDNSNVVAISQNGGTSTTKFEVPEKVESLARVIHYPDLQNASSVYPTPPDGALVPGMNQISADTLEPDCQDIGLSQTPGETPLKQQENVRKSSGDNEHMQVGTGLYDTNDDELFSGMDDEDFGSKGITDADFSFFDDDDDEMNDFMADKQETEHPKQGTLQPRSEEPDEVPVSQAEVQKDHVPTEDETFEHNETQKAKDAEPSALLEVDIKQPDITYQNTALQEAPSIPLEHTISAPLSPIDIKQMLFSNKDTKRIDGRRDSASSYPVLERKQSRYNAIPFKRGLTLDQKYANAGRFFFTANKDKSEDVNTTPGIPTIGFPRWRRSGPRDSIDEINISRQQGLEQPMQRTDSASSDESSLDSSDNESEDEASLFRLTSLKRKRPLSEAEKSTTSSMEKLSITSEVEAVVSKEDSSIFLGNFFSVLTDWSLVGYFSAKQSPISPVTSRKDDQMQVAQLMVDQITQSSLSHNIDGWEAVPDLDCQTIGLHTFLDEATSLGENERLGLKSYATLHDSLQSTAETPSARPNPQRREVKGSITKLAPSHLRIHRGRDFLEVLSTSMPFWETFGLEPASGQKDVSAYCICPQFVKEEADAFMTRLGQIYSGCNLGKHVRGDMSQTFENGIGVWNIAKGDGSYARTMQTLRGLCEELGTALSKAPSTGENFVIYIINPFSHGAAFVDICSTFLRLFQRYIGDVDKAHDKSRLNELVLQIVPLPFIYSPTSLVIPPQSEYLNLALEVYTRCPPKDANSGIIGYAPPVVLADAVPKAINFRVTSEPVSPFQEGRCLHVAISRSVDQRWISVAWSDNSGSCQITMSYCMRARGSNVNRSISEVRQEIWEATKDLMERTQTRWKVLLVRTEPVDQEEIDAWTGFAERYNQAKALPVELTLIYANIAPGLRLELPTQFQFNGINPLTSTPVATPYGGISSPDQLGAATPASGGQGPTNMNYNTAMTPTDTPPVLTEADSDAVLIDACEESWAVILSHRLSNSAYLTDYKPALVSGYLLRRKGINDSQGVTAMALNLVHTSRPPALHEAVLREVLASYRDLATLARAKGTLHVQHNTLPWHIATAVKGQELLSFVL
Length1498
PositionKinase
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index48.98
Isoelectric point5.09
Molecular weight165512.40
Publications
PubMed=25676766

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25472
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.94|      22|      63|     453|     474|       1
---------------------------------------------------------------------------
  453-  474 (38.80/20.01)	LQNASSVYPTPPDGALVPGMNQ
  484-  503 (29.62/13.57)	CQDI.GLSQTPGETPLKQQEN.
  514-  534 (36.52/18.41)	MQVGTGLYDT.NDDELFSGMDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.65|      36|      63|     884|     921|       2
---------------------------------------------------------------------------
  884-  921 (57.65/48.06)	HNIDGweAVPDLDCQTIGLH...TFLD.EATSLGENERLGLK
  946-  985 (54.00/36.56)	REVKG..SITKLAPSHLRIHrgrDFLEvLSTSMPFWETFGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.62|     102|     609|     667|     782|       5
---------------------------------------------------------------------------
  667-  782 (146.49/101.07)	DTKRIDGRRDSASSYpvlerKQSRynAIPFKrgLTLdqKYAN..AGRFFFTANKDKSEDVNTTPGIPtIGFPRWRRSGPrDSIDEIN.ISRQQG.....LEQPMQRTDS......ASSDESSLDSSDnES
 1278- 1393 (159.12/76.10)	DQEEIDAWTGFAERY.....NQAK..ALPVE..LTL..IYANiaPGLRLELPTQFQFNGINPLTSTP.VATPYGGISSP.DQLGAATpASGGQGptnmnYNTAMTPTDTppvlteADSDAVLIDACE.ES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.58|      10|      30|     618|     627|      14
---------------------------------------------------------------------------
  618-  627 (17.44/ 9.93)	SA.LLEVDIKQ
  650-  660 (14.14/ 6.63)	SApLSPIDIKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25472 with Med13 domain of Kingdom Fungi
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