<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25471

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEEGLDVDDLFGDPNSLDLGLATAQPTKGLAQHLDEMRLLGCCRKIAWSRLGCIAYISQDGLQVIVRHLACNPTDGKWGLSDEYPQNQIAQLHLGQQLLHLCWNETGSDLAVLDASGRISILSIPTALNNLAISRQTVVDPPDDGAQVVGMMWMNSNRAVHAFHQAAKVDVRWGYSAFRRKPIGPFHPAGKPALICFTRNGIMRLLYQNPDQRWAEVSAELKTTNQSDSILTHAACLPSPNGILVATHSFSGKLSLFRVQIMWNPPQWDPAQQRQAGVVHFPVPSIRISHCKTEVPGRVFSFSKDQADDLPNIVPGQSFSYQLTNLELVSGQSDNTGATTSAPWILAVYSSPINSAGHDTQQPASVMVRWQLETSTLNLHPVFEELVSKRANGQQRTKLEIRRLEDIHFDKHVVSIDHVEFGNVLAITHDDSSISIFDPRSMSQFTEGGDLNAVTSMAQAGFRFPVEAPGLNICFSPNGCLAVVLDTDWQAQLRIANYNFEPEGDLHDGKNSIGIIALSLAFCRGCAIEYNTDDLLVTISSQLSSEAQNVFVNEVYRALPINCNFSVEQEKPMQNPYVPRCLSLQAALGFQSSYTPRGLPSSVPWAILHLRHASLLFAFFFSYSKAPKENETLDHDVLQMVYGNTKWALDFTQYLLDDLFALAKEFEPVLDDKEALAQKVKTTSSLSLNLVLASMSRAFLHLVCRGLRGVHTSSIASPFAGDGRAYSKELYTLIDKAPVRFNVYEKFLNGVESAIKNAYQAQGLGDNDRRTPEKDLLLNSRIPAIMIPVIVSLFRQTIPAVQAEIDQMSIYLTDYSWLGVCDDRRTEHYRRTRHVDIVKKVPLRGFNSNNNTIEPDITSPSRRRCVRCCEVTGDPSSPRSLLYFNLTLRLQLIRNCLCGGMWTFEAGPPTTTTASTALPTHGPRVG
Length930
PositionTail
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.166
Instability index41.25
Isoelectric point6.18
Molecular weight103207.27
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25471
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     368.67|     139|     281|     190|     470|       1
---------------------------------------------------------------------------
   64-  229 (215.72/152.70)	DGlQVIVRHLACNPT.DGKWGLSDEYPqNQIAQLHLgqqllHLCWNETGSDLA......VLD...ASGRISILSIPTALNNLAISRQTVVDPP......................DDGAQVVGMMWM......NSNRAVHAFHQAAKVDVRW................................................................................gysafrrkpigpfhPAGKPAL.ICFTRNGIMRLLYqnpDQRWaevSAELKTTN
  230-  374 (143.09/320.45)	QS.DSILTHAACLPSpNGILVATHSFS.GKLSLFRV.....QIMWNPPQWDPAqqrqagVVHfpvPSIRISHCKTEVPGRVFSFSKDQADDLPnivpgqsfsyqltnlelvsgqsDNTGATTSAPWIlavyssPINSAGHDTQQPASVMVRW.....................................................................................................................................
  469-  501 ( 9.86/ 3.30)	........................................................................................................................................................qletstlnlhpvfeelvskrangqqrtkleirrledihfdkhvvsidhvefgnvlaithddssisifdprsmsqfteggdlnavtsmaqagfrfPVEAPGLnICFSPNGCLAVVL...DTDW...QAQLRIAN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     371.38|      98|     281|     506|     603|       2
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  506-  603 (168.73/122.99)	PE.GD.LHDGKNSIG..............IIALSLAF....CRGC..AIE........YNTDDLLVTISSQLSSE....AQNV.FVNEV.YRAL...PINCN....FSVEQEKPMQNPYVPRCLSLQA.ALGFQSSYTPRGL
  668-  777 (91.19/62.50)	KEfEP.VLDDKEALAqkvkttsslslnlvLASMSRAFlhlvCRGL..RGV........HTS.....SIASPFAGD....GR.A.YSKEL.YTLIdkaPVRFNvyekFLNGVESAIKNAY.......QAqGLGDNDRRTPE..
  779-  885 (111.47/78.32)	....DlLLNSRIPAI..............MIPVIVSL....FRQTipAVQaeidqmsiYLTDYSWLGVCDDRRTEhyrrTRHVdIVKKVpLRGF...NSNNN.....TIEPD..ITSPSRRRCVRCCE.VTGDPSS..PRSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25471 with Med16 domain of Kingdom Fungi
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