<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25470

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDSFSLAGNVSPTSFSASNLKANHSPDISNNSYPQTPTSPPLMSVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSATASFPTPASSVSGHLRNTTPADESEAADKSWGQGIQNSHATGSTEFGSVDRTGHRRTDHDRHKLPEGSNMKGRPPVADVDMMDIDSKEDLNSSIRDSSLDALQQDIGTAFHLCKSVPTITGPDPSFDLISLYGLGPIGRSVMRADPTTGEKINRLRKSYEGKLKGLGLSGRNKAVKNENGQSGGLRHLMMWPEEEWQIQKVHGKEIKFAEAESSLQKLQMRAMKLEPGPIPNSEYWEDILGHEKPAKHTNIENGKRAVSTPNALRPTNQANGVPATTAAPERARPTRGKKRHYDDNSFVGYGEGFVDDDDEAALYSNSEDRSGKKKRKKVFKSSRTHYQNVSYARTDGQLWGRHVWNRG
Length453
PositionHead
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.06
Grand average of hydropathy-0.921
Instability index46.25
Isoelectric point8.87
Molecular weight49389.82
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25470
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.25|      25|      33|      18|      42|       1
---------------------------------------------------------------------------
   18-   40 (35.70/15.42)	...........ASNLKANH.SPDIS.NNSYPQTPTS
   41-   75 (32.29/13.30)	PPlmsvgaqnyASNFAHTHtSPSHT.TTSNGQPLSS
   76-  103 (31.25/12.66)	PP......sstPMSTQNSQ.QPTVSaTASFP.TPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.09|      23|      37|     104|     128|       2
---------------------------------------------------------------------------
  104-  128 (37.25/21.99)	SV..SGHLRntTPADESEAADKSWGQG
  142-  166 (38.84/17.81)	SVdrTGHRR..TDHDRHKLPEGSNMKG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25470 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEAALYSNSEDRSGKKKRKKVFKSSRTHYQ
2) MSDSFSLAGNVSPTSFSASNLKANHSPDISNNSYPQTPTSPPLMSVGAQNYASNFAHTHTSPSHTTTSNGQPLSSPPSSTPMSTQNSQQPTVSATASFPTPASSVSGHLRNTTPADESEAADKSWGQGIQNSHATGSTEFGSVDRTGHRRTDHDRHKLPEGSNMKGRPPVADVDMMDIDSKEDLNSSIRDSS
3) PNSEYWEDILGHEKPAKHTNIENGKRAVSTPNALRPTNQANGVPATTAAPERARPTRGKKRHYDD
404
1
325
433
192
389










Molecular Recognition Features






MoRF SequenceStartStop




1) YWEDIL
329
334