<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25469

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMKPIEQWRKLLHECVSRRIEVDVFRRLVKILSRRAPLQQASLVNVLLGSQSITAEIFPYDPLIPRYATALRKLGLIRISTLLDGLRRQSFIEGQSTAVSDHDKSATEQNQKAVHRSTLMTDTRIVQDLIAPLSSTNLSFSTHDVQSIFMVTAEWILDVVRWHSGNISEDHQEGGLTSSPDALALFESLGILLVALSATAKGHDVLTSESAAEFKIPLGQALTAYLSTSATISLNLRNRLDSLQKGYQLYGGPASKDLDIQMMDGMNMNGLQFEASVLDGPVIDSRAGLYVYINALLVGRPLIDDEMLLSYLSNRYGGHQEVLIQELITATFDVLSNAMYRNESARNMFVFRSFLVNKLPPFLAGMAATSIEQIPMEMCISHALNRVDPNAFPSFSQMFEMQGNTVLSDVRQEFLFACALHRLIPETSIERLLGENPMQTLPVGGRYVKNDIVAQILSNQGVADRLISEIELMEGNAGAVVAAVTDVIHSLCEQKETVTLKGICNSLSRRPQVLDAMLLFRSPKSILQPLCTLLDSWKWDEDQGESQPVYDEFGSILLLVLAFKYRYDLSQYDLGVTASNSFVLKLLDRGSTSMKLAGLDAQQNKNVGAWISALFIAEGISEETMSSCSPQEFYLLVATLFSQTLGACEVGKLEFDTLKGGFEYLLEPFLLPSLVFALKWLGNYIWESSEADLLLLLKVLHALVKPNSISGEAEACHQMVLNITARSLEEQLKDVRTRLTGGRTDLHSDIQPSPHQDIQHEIQSLLDILDPYLSFQCNGNSRRSELDSWTTHADGICGVIRVTFQGLIMWSASAQMSMSPHTYTHRLILAGIRLSTASNVLSVLLDELKAQAEEASGSLDLAIDIAATLICVPMPESFAQEQTIYHPVDTTKEVFPRCLLLTLRQALMVQHQNVPKLAEKDPSRAEVIVRLTRRVNALLTPPAHVGTLDVTNIIDNMNLEAAAAAAAAGGDGLDLGNGNANGNTNNLGGAANESIDQILNNVVTATANNNDHGNEQHDLDTTGMDTSLDDILNAAHMGNPEFLDLDMDGMF
Length1050
PositionTail
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.06
Grand average of hydropathy-0.003
Instability index43.73
Isoelectric point4.94
Molecular weight115502.51
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25469
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.34|      14|      27|     524|     541|       1
---------------------------------------------------------------------------
  524-  541 (21.29/22.61)	SILqplcTLLDSWKWDED
  554-  567 (24.05/12.75)	SIL....LLVLAFKYRYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.07|      54|     248|     576|     638|       2
---------------------------------------------------------------------------
  576-  638 (76.75/80.40)	TASNsfVLK.LLDRgstsMKLAGLDAQQNKNVGAWISALFIAEGISEetmSSCSPQEFYLLVAT
  835-  889 (87.31/62.69)	TASN..VLSvLLDE....LKAQAEEASGSLDLAIDIAATLICVPMPE...SFAQEQTIYHPVDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.65|      17|      24|    1007|    1023|       4
---------------------------------------------------------------------------
 1007- 1023 (34.73/22.12)	NNNDHGN.EQHDLDTTGM
 1032- 1049 (30.92/18.87)	NAAHMGNpEFLDLDMDGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.48|      70|     279|     387|     465|       5
---------------------------------------------------------------------------
  387-  465 (107.09/86.71)	DPNAFPSFSQMFEMQGNTVLSDVRQEFLFAC.ALHRLIPETSIErllGENpmqtlPVGGRYVKNdIVAQILSNQ..GVADRL
  666-  738 (110.39/67.10)	EPFLLPSLVFALKWLGNYIWESSEADLLLLLkVLHALVKPNSIS...GEA.....EACHQMVLN.ITARSLEEQlkDVRTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.18|      24|      24|     947|     970|       7
---------------------------------------------------------------------------
  947-  970 (38.90/23.03)	LDVTNIIDNMNLEAAAAAAAAGGD
  972-  995 (41.27/24.86)	LDLGNGNANGNTNNLGGAANESID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.92|      19|      30|     892|     913|      10
---------------------------------------------------------------------------
  892-  913 (29.11/33.79)	EVFPRcllLTLR.QALMVQHQNV
  925-  944 (28.80/21.50)	EVIVR...LTRRvNALLTPPAHV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25469 with Med5 domain of Kingdom Fungi
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