<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25467

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLVMDDVSASASRYWGDSYNRYDSNGVPHADNHEKPAQQMNGFKGDGSTGQGSNMAMVTKHGQSDAMDDVSWQWAPPLTHITQGFFPYAQLVNRAVQQCYNDLCDVIAELAESTQPQQSSQATSANGKPDAAAIQKKIRILEFAQAKRTEFIKLLVLSQWSRQAVDVSKLIDLQNFIRTRHSAYQAAVQRVADMKRDLVRAQVANPDLQTALEVLTTGRVSNMPEFGYKPPKPLSPRRLLATLQKINRMISTRLVTSDVIPPSFNEYRVHDGRVTFSVKGEFELDLSIAEEDVASQFYFIDIRFLFTPSSPIPKGRFFNELDSQMNSILKAKGLTGCFDFLHNLVLVNKINILFKQAISLSRGQWIGALRVELLHRILVVHYWPDKSGPKSWLEIGAHSGRQLRQKISYLGLRWIREGKEFDSSHIHFDMENLSMESILRSVIAIHSSHILRNVYERFCTQTLFANHQLSINLQISRTEPGNCRLNVQLTGSRYLNASVEPVSGAMCIHTIPSLLCRLDKGGNSDDDLVNRISRLRCIAAMEEIESDAKTFGWESVDHRKFKVDIRRVFPSNVLRASFFRNRLFGNSWIIAATTSLSGDDWWLLRLKARPSPSPELAVHARIIPGGFSVQSTRVLSGDLFLSSQGARYHFPDLDYSLTGALVMYSNALWLSELGYQDCLPPVEQLQLGSRLEVPCLYLKFDIAKLPKQLRIAPLNGTQSKSYIRDTLSISYHGIDSRTKNAIVVAHGRFLTPLRKLGLKRLKLDDCILLRRGGMGFAMRFLVAPGQSIMLDLFERIQRLNIVLSLFRTLQKHKITVKSVSLSNLSFVYAPQEGFEANIVIRLDGPGNTPDLDPAIIRQQNEPLFRLRLDISFNNLSPHNRIKQSLGTILNRSGPGYGVQCVLQLLKLTLSVLRALDRLVTEPKHNSALRVQVSIRGAQTYQIHYFGLRFRFLLTASQRRGSIIWTLKDISSSEGQRDVEQAVEAKLQEKIYRGKGDGWQGLGNGAVAKVDQVGNLLSELDSCFADLTPPSAPPEKAALCEAAEKKMSKIVKDKGPKTNGPSRMPNRHPQGAPKESDVITID
Length1083
PositionTail
OrganismTalaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.252
Instability index43.32
Isoelectric point9.47
Molecular weight121524.07
Publications
PubMed=25676766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25467
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.17|      98|     167|     460|     624|       1
---------------------------------------------------------------------------
  395-  499 (156.09/118.44)	LEIGAHSGRQLRQKISYlgLRWIREGKEFDSSHIHFDMENLSMESILRSVIAIHSSHILRNVY..............................................erFCTQ.TLFANHQLSINLQISRTE.PGncrLNVQLTGS..RYLNA
  520-  669 (133.08/128.59)	LDKGGNSDDDLVNRISR..LRCIAAMEEIESDAKTFGWESVDHRKFKVDIRRVFPSNVLRASFfrnrlfgnswiiaattslsgddwwllrlkarpspspelavhariipggFSVQsTRVLSGDLFLSSQGARYHfPD...LDYSLTGAlvMYSNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.65|      32|      60|       6|      41|       2
---------------------------------------------------------------------------
    6-   41 (55.06/45.11)	MDDVSASasryWGDSYNRYDSNGVPHADNHEKPAQQ
   69-  100 (61.59/39.96)	MDDVSWQ....WAPPLTHITQGFFPYAQLVNRAVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.14|      46|      64|     786|     844|       3
---------------------------------------------------------------------------
  786-  836 (61.47/53.93)	PGQSIMLD.LFERIQ.....RLNIVLSlFRTLQKHKiTVKSvSLSNLSFVYAPqeGF
  847-  898 (70.67/53.23)	PGNTPDLDpAIIRQQneplfRLRLDIS.FNNLSPHN.RIKQ.SLGTILNRSGP..GY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.30|      29|     430|     302|     372|       4
---------------------------------------------------------------------------
  307-  335 (51.82/57.24)	LFTPSSPIPKGRFFNELDSQMNSILKAKG
 1028- 1056 (50.48/10.74)	LTPPSAPPEKAALCEAAEKKMSKIVKDKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.53|      20|      68|     681|     701|       9
---------------------------------------------------------------------------
  681-  701 (31.76/24.39)	LPPVEQLQLgSRLEV.PCLYLK
  752-  772 (29.76/17.19)	LTPLRKLGL.KRLKLdDCILLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25467 with Med14 domain of Kingdom Fungi
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