<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25453

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAEESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLEVLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSSFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFSPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTEHVIADGSKSLQLVPASKINGSINLITMGSDGASRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVKLNDKLDDDQTSTDIKTQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHVPSPANVAATHLGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQPAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDMATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismOryza sativa subsp. indica (Rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza> Oryza sativa.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index50.45
Isoelectric point7.99
Molecular weight190347.76
Publications
PubMed=15685292

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25453
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.00|      49|     105|     206|     254|       1
---------------------------------------------------------------------------
  206-  254 (81.09/51.98)	LLTLGYRGHLDL..WRI..LHLEVLVGDKGGPIKLEER.RRFALGDDIERR..MAV
  257-  297 (45.19/25.48)	......NPFMVL..YAI..LHELCISLAMDTIIRQTNVlRQGRWKDAIRSE.....
  312-  363 (59.72/36.21)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDS.SPFI...KIEARqdMQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.10|      11|      15|    1177|    1187|       2
---------------------------------------------------------------------------
 1177- 1187 (21.58/10.62)	MNNIPTQGPLA
 1195- 1205 (19.52/ 8.93)	MHHVPSPANVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.53|      21|      24|     814|     835|       3
---------------------------------------------------------------------------
  514-  532 (27.81/10.99)	RTRSILHLFAATGSFFGLK..
  814-  834 (36.26/17.88)	RKRSISDLFLNLPSLQGLKPS
  838-  855 (30.46/14.40)	KRRRISE...SMESWSPLQAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.70|      24|     135|    1148|    1174|       4
---------------------------------------------------------------------------
 1148- 1174 (38.55/33.67)	GPLLalGGAI.....RPARMPvTVSSGYNSM.P
 1281- 1310 (36.15/20.72)	GPLV..GGSLpcpqfRPFIME.HVAQGLNALeP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.58|      72|     567|      85|     158|       5
---------------------------------------------------------------------------
   85-  158 (124.45/81.56)	PLVNYCQQlgSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQ...NKLSP
  655-  729 (119.13/72.23)	PLLPACSP..SFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAysgSKFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      32|     131|     944|     975|       7
---------------------------------------------------------------------------
  944-  975 (59.56/38.13)	LRLGKAGSMS.W..DVRINDPHFRELWELSTGSTT
 1078- 1112 (52.12/32.41)	FRIEAVGLMSlWfsYGTMPMVHFVVEWESAKGGCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.97|      23|     136|    1210|    1236|      11
---------------------------------------------------------------------------
 1210- 1236 (34.28/26.04)	GSHNlHTAAMLSaagRGGPGLVPSSLL
 1352- 1374 (40.69/19.59)	GVAN.HVAANLS...RAGNAMLASSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.16|      21|     100|     459|     504|      13
---------------------------------------------------------------------------
  482-  504 (30.91/47.12)	SPENILPPSALLdcEEALNKGSI
 1116- 1136 (40.25/10.51)	SPDQLWPHTKFL..EDFVNGGEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.62|      45|     194|    1412|    1465|      16
---------------------------------------------------------------------------
 1421- 1465 (72.79/52.87)	ALKKVL.RGILKYLGVLWLFAQLPELLK.EILGSILKENEGALLNLD
 1621- 1667 (71.83/43.23)	ALTFVLdHALIPHMNVAGGAAWLPYCVSvRLKYSFGESNHIAYLAMD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25453 with Med14 domain of Kingdom Viridiplantae
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