<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25420

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMQHTHFSSIHHSNNNSSSHISIIEKTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQWIVRFIHGQHSPKRIAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFDPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSAVLSSGSDWLGYPFQLLDFTACHQSYSEMHCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVSNSSSVQQTSSASSPTAQSTAGAAIPLSVTQ
Length1387
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.10
Grand average of hydropathy-0.022
Instability index45.09
Isoelectric point7.46
Molecular weight158086.48
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25420
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.60|      16|      17|    1006|    1021|       1
---------------------------------------------------------------------------
 1006- 1021 (31.60/20.51)	YKFHDRPVTYLYNTL.H
 1023- 1039 (25.00/14.70)	YERHLRDRTNLKRKLvH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      13|      17|     268|     280|       2
---------------------------------------------------------------------------
  268-  280 (25.49/17.09)	PYDKDLFDPQTGL
  288-  300 (26.13/17.73)	PYSRDMVCNMLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.70|      15|      20|     478|     496|       3
---------------------------------------------------------------------------
  478-  496 (20.72/20.24)	LPMTdykiALLCNAYSTNS
  501-  515 (25.98/13.76)	LPMG....VLVETIYGNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.93|      31|     785|     185|     215|       4
---------------------------------------------------------------------------
  185-  215 (56.63/29.61)	NACL..LPAY.FAVTEIRKLCP.....EGALSHWLLGSL
  902-  928 (42.29/20.43)	...L..KPND.FR.NRVSDFVK.....ENAPEHWLQSDW
  969- 1005 (33.01/14.49)	NVCLrfLPVFdIVIHRFLELLPvskslETLLDH..LGGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.04|      18|      20|    1046|    1064|       5
---------------------------------------------------------------------------
 1046- 1064 (31.30/21.84)	KDNRTPGWCLSETYLkCGM
 1065- 1082 (34.74/19.87)	NAREDNVWIPDDTYY.CKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.85|      34|     785|      80|     113|       6
---------------------------------------------------------------------------
   80-  113 (63.06/39.65)	GQHSPKRIAFLYD...............CL..AMAVETSLLP.......PRMVCQALI
  794-  831 (33.45/17.55)	.QGSPP....LFL...............CLlwKMLLETDHINqigfrvlERIGARALV
  851-  897 (47.34/27.92)	GQQLNKCIEILNDmvwkynivtldrlilCL..AMRSHEG..N.......EAQVCYFII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.09|      39|     716|     575|     648|       7
---------------------------------------------------------------------------
  529-  572 (53.62/58.19)	GSVTPLPMNLLDSltvHA.............KMSLIHSiATRVIKLAHAKsSLALAP
  594-  645 (63.47/66.89)	GFISQLLPNVFKS...HAwgilhtllemfsyRMHHIQP.HYRVQLLSHLH.SLAAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.50|      31|      53|    1246|    1279|      10
---------------------------------------------------------------------------
 1246- 1279 (46.01/44.05)	LKPIVKTEFQLLYVYhlVGPFLQRfQQERTRCML
 1302- 1332 (57.49/40.59)	MDPICDFLYHIKYMF..TGDSVKD.QVERIICSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      12|      20|     362|     373|      11
---------------------------------------------------------------------------
  362-  373 (21.06/12.37)	HMVLSLHQKLAG
  382-  393 (22.76/14.00)	HLMWVLLQFISG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25420 with Med23 domain of Kingdom Metazoa
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