<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25391

Description "Thyroid hormone receptor-associated protein, putative"
SequenceMIPLGHLARVTADELTAINVKQGFITNPQISDEYGSARNANITPAKFGAFFSAILAKKQELNTIQDSGRKRQQINTKEHFWPVTARSKNAIEAWFKDLAGSKPLTSLAKKVPIFNKKEEIFLTLFEFSVPMLRAAWFIKMTSVYQVAISEAKMKKRQLPDPCQEWTTPLCKFLRELLHKLVEHSHPTGPPPGSGGSLGSQGGGTSPAPSAPSIPPDTTIAKQWQYCTQLASYLYEEGLLDHQDFLSWILELVEKTKTPDDPILKLVMPLTLQYVDEFARSELLSRRLAHHCCKKLSQLITDYNMASPRSQSPPSSVGPLAASFAECLSCSHHRSIVLQLSAVLQVITLECPSALVWNNIGEGKANPILNGSPLDILPCPPSCLPMAPRPYNAQVRLELRRAEQQVIQRGRAAELQWSCDKWQQMAAGTTITRVLGALDALDRHSFDRVEANNSLDTLYAKIFSRADQSQAPMAAGGGAGLEGGAPQLVAPPPQDEPIVRLLCEWAVTTKRSGEHRALVVARLLEKRQNELSVEKYNDADLVDEKDSQDSGAPPMGLPVFQNLLVNFLDTEAPVLDDKPTFENRAVFANLVLLFAELIHCDVFSHDAYMCTLISRGYFASHPPGGATLPSTANPPATGGTPEPSLTGFLDPSLGPSPGPVGVGWNVQMDMDDAGLDADLDKILQNIKEGQQNMSDQPDSVGSDKEEGGSLQGPNTPLVDHPGVGGGGSGHGGGLSGGDRTASGGAQAATRSKNWALRHLQYTTHFPLPQEGGLWSHDCNQRHILLYGVGKLRDEARHALKKVTKELLKLFAKKASMDIADGGKVKRHARDAFNFEAVTARFQALSFFDQHVVAQTCAASVLEMLGGFAAGSSNHLPLVDYIAFLFDLMELSLNIHGLIEFGLQLLKELVEVENQLAQKGSALSGTYATSLGLYIVGLFYRYHCCLLVSQDYTLQACESLCKIVKNVANPAECTSAERCILCYLHDLYSSCYYFKSKHSEIFGSFYSKVKQTLYAPQTPSALNLLWNTTYMIECINNPRLNEISTLCAELTASCGSLSAEWLGVLKALCCSSNHACGFIDVLTQVDVGDLSIHDNLAVFTCILVARRCFSLQDFVVHVAIPSLLSASPVSGAADQDAESGARLTCHLLLRLFRTVDPSPPPSLPRPLFLIRSPCDRHLLSAAHSSMRVEPVLAVLKAILVLGDASTPGMEAKSKMDSSQGKGEPSINELLGSIDDTDFDLGVPPSLGRHPSSVGGSRGTATESAGLNDFAKYALGQICSQQWIHERCLRDPDVLCSSDLLLDPMLSHKQAETLLQMICHPKGNGRSSEESCNQKQVVTQILLGLDQWSLRVSWLELQLMYKQCASPPEVSAWLENVAKATIDAFQLTSEDSRSPGGAGDPSAALFGRSGGNGSGRQETDRIWFVAPLIAKLPAAVQGKVLRAAGQVLESGSWASITSSSSSKSKDKDKHVHKRQDPVQFSIRLGASLLSHQPFLSLVLMCLKGQDEQREGLLNSLYSQLNQCLHLAKDEKPVAEDLKGRQLLHEALLLRLSLVGGMFDMIQRSNTLTTDWALVLVQLISYGVVDLHSNFELFSTVLDMLAVLIHTTQNLDSLSGEETRKQYLNLVKKLKKEVSDLDTDAIKMVHQLLPLVKQQCEVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSEKQCVSPWDLLEGHRNPAPLSWVWFGAVRMERKPRPEESHRALLWHTHGSLAKPLGYFAEPPPLPPEELLLEPPPAPHLPPHLPPHHPHLPPPPDKHHLQASGTSPELAEL
Length1797
PositionKinase
OrganismIxodes scapularis (Black-legged tick) (Deer tick)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Ixodida> Ixodoidea> Ixodidae> Ixodinae> Ixodes.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index48.81
Isoelectric point6.12
Molecular weight196317.26
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.49|      18|      21|    1747|    1764|       1
---------------------------------------------------------------------------
 1158- 1175 (34.58/13.67)	PPSLPRPLFLIRSPCDRH
 1747- 1764 (37.24/15.33)	PPPLPPEELLLEPPPAPH
 1766- 1783 (43.67/19.33)	PPHLPPHHPHLPPPPDKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.64|      19|      21|     692|     711|       2
---------------------------------------------------------------------------
  180-  205 (29.60/10.90)	LVEHshptgppPGSGGSLGSQGGGTS
  692-  710 (32.24/12.93)	MSDQ.......PDSVGSDKEEGGSLQ
  716-  734 (37.81/18.23)	LVDH.......PGVGGGGSGHGGGLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.56|      14|      15|     634|     647|       3
---------------------------------------------------------------------------
  634-  647 (26.00/11.88)	PATGGTPEPSLTGF
  650-  663 (30.68/15.51)	PSLGPSPGPVGVGW
 1242- 1253 (19.88/ 7.14)	PSLGRHPSSVG.G.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.99|      11|      15|     603|     613|       5
---------------------------------------------------------------------------
  603-  613 (21.82/11.35)	SHDAYMCTLIS
  619-  629 (22.17/11.67)	SHPPGGATLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.59|      14|      20|     548|     561|       6
---------------------------------------------------------------------------
  548-  561 (28.01/17.07)	DSGAPPM.GLPVFQN
  568-  582 (21.58/11.19)	DTEAPVLdDKPTFEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      15|      38|    1499|    1513|      10
---------------------------------------------------------------------------
 1499- 1513 (25.72/17.04)	LKGQDEQREGLLNSL
 1534- 1548 (24.79/16.11)	LKGRQLLHEALLLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.10|      16|      38|     889|     904|      11
---------------------------------------------------------------------------
  889-  904 (27.78/16.75)	LSLNIHGLI.EFGLQLL
  929-  945 (27.32/16.34)	LGLYIVGLFyRYHCCLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     264.92|     106|     595|     752|     871|      13
---------------------------------------------------------------------------
  752-  835 (101.22/63.65)	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NWALR......HLQYTTHFPLPQEGGLWSHDCNQRHILLYgvgKLRDEARHALKKVTKELLKLFAKkasmdiADGGKVKRHARDAFNFEA
  836-  871 ( 3.39/ 7.07)	VTARFQALSffdQHVVAQTcAASVLEMlGGFAAGSS..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1344- 1423 (103.00/49.03)	....................................nhlplvdyiaflfdlmelslnihgliefglqllkelvevenqlaqkgsalsgtyatslglyivglfyryhccllvsqdytlqaceslckivknvanpaectsaercilcylhdlysscyyfkskhseifgsfyskvkqtlyapqtpsalnllwnttymiecinnprlneistlcaeltascgslsaewlgvlkalccssnhacgfidvltqvdvgdlsihdnlavftcilvarrcfslqdfvvhvaipsllsaspvsgaadqdaesgarltchlllrlfrtvdpspppslprplflirspcdrhllsaahssmrvepvlavlkailvlgdastpgmeakskmdssqgkgepsinellgsiddtdfdlgvppslgrhpssvggsrgtatesaglndfakyalgqicsqqwiherclrdpdvlcssdllldpmlshkqaetllqmichpkgngrsseescnqkqvvtqillgldQWSLRvswlelQLMY.KQCASPPEVSAWLENVAKATIDAF...QLTSEDSRSPGGAGDPSAALFGR......SGGNGSGRQETDRIWFVA
 1425- 1489 (57.30/22.83)	LIAKLPAAV...QGKVLRA.AGQVLES.GSWASITS...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................sssskskdkDKHVH......KRQDPVQFSIRLGASLLSHQ...........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.01|      16|     597|    1055|    1078|      14
---------------------------------------------------------------------------
 1038- 1053 (27.81/18.74)	LNEISTLCAELTASCG
 1060- 1075 (30.20/16.17)	LGVLKALCCSSNHACG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25391 with Med12 domain of Kingdom Metazoa
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