<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25384
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MEGGSPVRRGVGMIPQQEYLLQGSIMDGACEVLLHRLRGLCDNSDSPIESFHDYEMVFQIRKTTSSGVCGPTSAPLSVRARQSLDSPQMPWHLRYVGQPEVGDRSRHTVVRSCIDVSTSNNLVSFLNELGFRLDFEFVLKGHMFQKGRMKVIVAKVFRLLQQGNPDSCEPVSQSHIIELSVIAPGGQESLGDEMKAFADQLKPLVELEKIDHTRLQHL |
Length | 218 |
Position | Head |
Organism | Ixodes scapularis (Black-legged tick) (Deer tick) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari>
Parasitiformes> Ixodida> Ixodoidea> Ixodidae> Ixodinae> Ixodes.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.258 |
Instability index | 59.95 |
Isoelectric point | 6.24 |
Molecular weight | 24344.62 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
termination of RNA polymerase II transcription GO:0006369 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP25384
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.77| 10| 26| 39| 48| 3
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39- 48 (19.29/10.80) GLCDNSDSPI
67- 76 (19.48/10.97) GVCGPTSAPL
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