<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25383

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAVEKPAEANPSPQVGIKELAEPAPVIGKDNAKESPMENLLEKLRAKASQYKPWGDMAKALRMALMEKHHLVDSADRNRLQKCLDTIQKLIFTTGPDGQECFISSDMFYVEVLLETSGEVKDVKIAHHGDPVSCPELTQVLLKGDFAEFTSHLEGLASIYQLNADNLPSFAALSNLNSTTLPASFVLKLPQPIPMALALVRKIHAITSIECADTTCCQSLLSLIITQASEGKLNGSSDRGLNVTLPDQHHCYYLSGSPDLQGVLVSGVQFTHPTHVPQILVFLRQQLLFNSLIASCVRPASRQNAESSHMFEVSTTSISNISISFEHPLDESLATVDLNLNEITSVKCRIYTLNSDISICSDEYASKVMQRCLSIPVTMRAVIRKAQGQRMRMSNQTDSYYSALNSNGPSYLPHLPGYGGGAGGGAFGSGGPDFASGTPPPKRGGTLGSLLGQGGGGAGFQQPGGGPGKQSAQPNMMLMSMLSDVPSASSSPSPSQQSSYPFLSQAKPRKQRKRKATSSDGRSPKRKAGVEDDGGGGTPTPADLEDSTSISLTSFEGRQTPSGDAPSFGKGDGGHTLPGEPFLEADAGQKKAALLNPAESSSVEEFHQRRPLQSPSESFRGFLSEGPPGDATGDDCKPGTKALPASQRPLAAPPQCRKIKRVKSEEGRGEELKLEREGSRSQDSGPKNLLPGGDSERLLASSLGGSVASAAGKSHSVSPPVIATSFKIEKSGDGLKISKAEGRQSSTKGRDPKGRDNRKERKRKRAESVDLSSSHGAKLAFDTSSLDSVLQATLLPLESGDGALHAFNLTMKPQGSVSPALGQAAPARVMGKKSGSQGSLPSGGNGKSDKPSKPLSGAKTNEVDGRLATSPTKLLKHKPSPGPPKSGTGTPGRPACYAGQPSLVGPNTSPSKPSSKSASAAPPGSTLKLKHLNLPSSTTITPVAPKVQPAQLPSPSSSSAASITIVPTGGASSNNLNKPPKSRKGSLSAVIAKLTNTAAPSLPPVDPSSGPPRLEGGVKSSEKRDSPTLGKESKDKEALLKNSEGKMKYSSSDQFTVKQSSGIKLTVTKTSGTYKSSSSKAKMGMSSSKASAGVSSSSKAKGTGSLGSASRPPGAPGGLAKKPSSLSSSSLSGLGRAPSKPSQKSSSPNTTNPAISQNPLNPSSALRSKTPTSGSTPKRPDEFPGAEENDPDRALRLLLSQPKAMESTQPLEQWQPLSLKSQTPPSVDSSVKPDFEDKTPWVSSSTDVKPNNSIATVVAKAPLENGPDSALTPTDLSSSSPRFELISSTLEEGANTTTPSFKALPLLLSASAPSKLPAKTKPTSDEDSSPEDGLVIDFPESIDSKKGSSSLSSSRAQSPKDGSGGGGGSQESGTSLKAAVSPGPALSAKSPYFTAQSPSLKSPQVGSPPSNHSVSSSISRPSPCVIDDDLMDEAIMGLGK
Length1441
PositionMiddle
OrganismIxodes scapularis (Black-legged tick) (Deer tick)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Parasitiformes> Ixodida> Ixodoidea> Ixodidae> Ixodinae> Ixodes.
Aromaticity0.04
Grand average of hydropathy-0.536
Instability index54.52
Isoelectric point9.26
Molecular weight149694.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25383
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     480.80|      64|      65|     640|     703|       1
---------------------------------------------------------------------------
  375-  440 (35.78/ 6.44)	SIPVT.MR..AV.....IR..KAQGQR.M..RM.................SN.QT.DSyysalnsnGPS...YLphL...PGYG.....GGA.................................................G.....G................G...AFGsggpdfA......SGTP..
  441-  516 (40.60/ 8.58)	..PPK..RggTLGS...LLGQGGGGAG.F..QQPG.............GGPG.KQ.SA........QPN...MM..L...MSMLSDVPSASS..........................................spspsqqSsypflS................Q...AKP......R......KQRKrK
  517-  584 (56.57/15.66)	ATSSD.GR..SPKRkagVEDDGGGGTP.TpaDLED.............STSI.SL.TS........FEG...RQ..T...PSGDAPSFGKGD.................................................G.....G................H...TLP......G........EPfL
  585-  651 (58.13/16.36)	EADAG.QK..KAAL...LNPAESSSVE.E..FHQR.............RPLQ.SP.SE........SFR...GF..LsegPPGDAT...GDD..............................................ckpG.....T................K...ALP......A......SQRP.L
  652-  717 (88.36/29.78)	AAPPQ.CR..KIKR...VKSEEGRGEE.L..KLER.............EGSR.SQ.DS........GPK...NL..L...PGGDSERLLASS...............................................lgG.....S................V...ASA......A......GKSH.S
  869-  920 (52.01/13.64)	ATSP...T..KLLK...HKPSPGPP.........K.............SGTG.T...P........GRP...AC..Y...AGQPS..LVGPN.........................................................................tspSKP......S......SKSA.S
  921-  977 (36.22/ 6.63)	AAPP....................GST.L..KLKH.............LNLP.SS.TT....itpvAPKvqpAQ..L...PSPSS....SSA................................................aS.....I................T...IVP...tggA......SSNN.L
 1012- 1114 (35.14/ 6.15)	..PP...R..LEGG...VKSSEKRDS.......PT.............LGKE.SK.DK..........E...AL..L...KNSEGKMKYSSSdqftvkqssgikltvtktsgtyksssskakmgmssskasagvsssskakG.....T................G...SLG......S......ASRP.P
 1115- 1212 (39.37/ 8.03)	GAPGGlAK..KPSS...LSSSSLSG.......LGR.............APSKpSQkSS........SPN...TT..N...PAISQNPLNPSS.............................alrsktptsgstpkrpdefpG.....AeendpdralrlllsqpK...AME......S......TQ.P.L
 1316- 1400 (38.61/ 7.69)	KLPA......KTKP...TSDEDSSPEDgL..VIDFpesidskkgssslSSSR.AQ...........SPK...DG..S...GGGGGSQESGTS..........................................lkaavspG......................P...ALS......AkspyftAQSP.S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.95|      13|      17|    1070|    1083|       2
---------------------------------------------------------------------------
 1070- 1083 (19.46/12.63)	KTSGTYkSSSSKAK
 1090- 1102 (22.49/10.22)	KASAGV.SSSSKAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.00|      18|      24|     766|     787|       3
---------------------------------------------------------------------------
  766-  783 (30.35/21.70)	RAESVDLSSSHGAKLAFD
  792-  809 (31.66/12.97)	QATLLPLESGDGALHAFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.94|       9|      22|     815|     824|       4
---------------------------------------------------------------------------
  815-  824 (12.91/ 8.11)	QGSVsPALGQ
  838-  846 (18.03/ 7.29)	QGSL.PSGGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.94|      34|     134|     179|     212|       5
---------------------------------------------------------------------------
  179-  212 (58.30/32.88)	STTLPASFVLKLPQPIPMALALVR.KIHAITSIEC
  315-  349 (52.64/29.01)	STTSISNISISFEHPLDESLATVDlNLNEITSVKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.31|      10|      15|      37|      46|       7
---------------------------------------------------------------------------
   37-   46 (17.01/ 8.79)	PMENLLEKLR
   54-   63 (19.30/10.89)	PWGDMAKALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      15|     108|     737|     756|      16
---------------------------------------------------------------------------
  731-  745 (23.58/18.91)	KSGDGLKISKAEGRQ
  751-  765 (25.33/ 8.05)	RDPKGRDNRKERKRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25383 with Med1 domain of Kingdom Metazoa
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