<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25372

Description Cell division cycle 2-like protein kinase 6
SequenceMGDGRTGGANRPAWLQQYELIGKIGEGTYGLVFLARLKPPHPAPGRRGPPIAIKKFKQSKEGDGVSPTAIREIMLLREINHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHREKLSSSINPYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGDEHGIIKIADFGLARIYQAPLKPLCDNGVVVTIWYRAPELLLGGKHYTSAVDMWAVGCIFAELLTLKPLFQGVEAKNPPNPFQLDQLDKIFKVLGHPTVEKWPTLANLPWWQNDHQHIQGHKYENPGFHNIVHLPPKSPAFDLLSKMLEYDPRKRITAAQALEHEYFRMDPLPGRNALLPSQPGEKIVQYPIRPVDTTTDFEGTTSLQPTQPPSGNAPPGGQSVARPMPRQMPQQPMVGGIPRVAGGVTMAAFNAASQAGMAGLNPGNMPMQRGAGGQSHPHQLRRKADQGMGMQNPGYPQQKRRF
Length471
PositionKinase
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.08
Grand average of hydropathy-0.442
Instability index41.16
Isoelectric point9.37
Molecular weight52503.80
Publications
PubMed=18937034
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
cell division	GO:0051301	IEA:UniProtKB-KW
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25372
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.64|      44|      55|     336|     388|       1
---------------------------------------------------------------------------
  336-  388 (62.04/50.98)	PLPgRNalLPSQPgekIVQYPIR...PVdTTTDFEGTT..SLQPTQPpsGNAP....PGGQS
  392-  444 (71.60/33.78)	PMP.RQ..MPQQP...MVGGIPRvagGV.TMAAFNAASqaGMAGLNP..GNMPmqrgAGGQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.26|      29|      42|     165|     194|       2
---------------------------------------------------------------------------
  165-  194 (48.08/35.28)	GDEHGIIKIADFGLARIYQA..PLKPLCDnGV
  208-  238 (49.18/31.24)	GGKHYTSAVDMWAVGCIFAEllTLKPLFQ.GV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.64|      10|     169|     284|     293|       4
---------------------------------------------------------------------------
  284-  293 (21.57/11.26)	QGHKYENPGF
  455-  464 (22.07/11.68)	QGMGMQNPGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25372 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPLPGRNALLPSQPGEKIVQYPIRPVDTTTDFEGTTSLQPTQPPSGNAPPGGQSVARPMPRQMPQQPMVGGIPRVAGGVTMAAFNAASQAGMAGLNPGNMPMQRGAGGQSHPHQLRRKADQGMGMQNPGYPQQKRRF
335
471










Molecular Recognition Features






MoRF SequenceStartStop




1) HPHQLRRKADQ
2) PGYPQQKRRF
3) PIAIKKFK
445
462
50
455
471
57