<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25362

Description "RNA polymerase II mediator complex component Srb8, putative"
SequenceMIPHPSSTGLQTWTNQHRASGTTDRSSMAVARTPSSAQQLIDLSASDGPAEIEHSHKRPRLDTTVPGLGGDGRAPSSRSADARSATTGSNPTRPAAVSGRGRPAYSFQELVADTYGGSVFAGNSTPASQTSKPPSPPPFPVRPWTHTPARLSQVENEGISDNLRAREVQTVPYRPVTPEIAPNLTRDKVADYAPWSRTGNHPEDRLSDLNVKAGNFDRVPGPNTNSDIQSHASKLSSQLKNHSSLQLLSSVFAAALEKRQIHEKISSTSTFKPPPRVTLTDNKREAWLRDLANSSVPLRRLSRTIPHGIRGKVLLDQCLGKGVPIGRAVWLAKCVGANEIRAFKRKGTSGSLSQGLEIKWVREWTLSVQQFTAGVISACGKPDWRNKMTYAVRLAARLFYEQLLDQDCYLDWYLSSMEGSSLDAFPIWLAMLSIYWGSLVRFRKRGRRLAEILLEKLREATSSEFKVNLQPLIERVSLLVRRLCRENSPCLILPRSWDRYQDIVASSLSDDSKEKAILQSLVLRNARVQRPGTCCPARQRSPQEQVIKLLDASRDTCNMCALSSSCLALIPDRQELVSVLLRWAASPFRQSLVRVYIAVRLFRKWKRSGMDIDACIFPFLTQTSMDQSTSSLTNVYHIIVELIRSQTFSVGRYLQWLVARGAVEQYRQQYSQASSVPVDIALLSHIPVARLPRHLRNLRDTLMARAGLPSSEAEVLHSIKADLKQRLPGLLGKDDFHMNINYDQNNLSWSVKADISQWIRAAVSEHYENGSAYHPKMYENNVEVSSLTQEEFLVVRSTLEQYGDLSMLADILIDASNSDDVRLLTCAVDTLNRHFECFTIIGALGDMFRSFYETFLRMKANGQPLYDLAYSMAEVGHRLPNEVNSLVLIRQELSRADRNLALAACSPVSDHMAETLNDASPSFNEDMDHFLSSGNSMDEMTMILVFQKLIQQLAFYDEKNPSMPGTVCRHLVQLRSFNSKHFDLLLVQWLGATLKSTSRPSLSRLLYPLVGIGCVTLPAFAALMKKLLQSGSLQTVNSALPDSLVDFLELLVLNNSAEPLRDFLTYRFHIAQEEFLQGHSHEVIALLKDAVPHMTLGTHDIISSVPCVVPLLSEIIVRHPDDATLDSIRTLMKNSPIFLPVVRKSLDLLLNDHRSNSDFLMETAITIKKTNHLSLPLCQMKLQILFEEKNDDSIRNNIVDLMYKSAVADVRAGNSYWLDLVSTMGQEAAEQLRQRAEKDFFSVAQSESAVEKDLENERLCLQENARVYLAIVDGLAYSIPEEGVPSVAPVLVEKMNTLLQKLFTMHMNVRNWSENRSRSSQEAMTLSLSGCEENFVFWLTSMLQMIRIHRAAFDLPVSAGNQRLGAYVDLSRLLIIICCLALSRTPLGLTVQPRLDLSASSYFLASAKEVRAGNTIQTYALDIASSLVDSLPDEARQHCANFIKERFPPALNVQNDPRLQYLFGPVAENIGNLGGALPSSMSVSSPAATLTPSNNPVNAATAAGGNTIEDPLALNNRLRVQSRGRVVGSYPVRPWEMLEEAAPVVGANDTAIDLNLFGARKSCAMIFEDGCQRSHKNEQHKKEDASTIHIDLTTGDIKVIKRWASARKRRKEEIGGGQQEGKPKNEESGTAGRLAFLLQHRRASVRMALFNIAEAVDSNFSLRFPVVTILVLLILYPIFQIVYNVFFHPLAKIPGPFLWSASRIPFVYHLLRGSLIKSQRRFHNKYGPVFRMAPDEVSFASEEAFYDIYTWRAGHKRAMRDPAFFQPPEGQADNLITTNNVKFHARIRGLMSHSFTEESLYEQAPLIEGHADVLISQLQQRATSSENLESGALVNVTDWVNFFTMDVVRDCAKPNVFLCYTILTSSQIGDLALGEDFGCLVKGEYHDWIRTLFQYLKAMTIAAAPRYWPVMQFLFEKAIPKSIKDDAKRHQQYAYDRINRRLDSKTDRQDFITPFMKHNPNFENMSREEILSSFSFVIIGGTETIATSLTGLFNHLAMPQNKAILDRLTKEIRSTYKTEDDITVESITRAKLPYLEAVIQEGLRICHPVPSGLPRIVPPGGDEYTGIWLPGGTRLGVRIFAVNRSAKYFQDPDTFVPDRWLPDGERPSEYDNDNLSASKPFGVGFHSCLGKLLALVEIRLVLTRILWAFDIAEEEGMHVHFDDFPVMMMVEKQPLMLRLSARKGVNYKAAGVNTAQVDPLGQGVSKSKPGSSKTTFRPVFTQVSLPATARKQANQGISNEKRDKRPVMHASKLRGDATCNILHVGDVSSRVLRASILRRGFMTMLYFFDNNYATQSMQFFLLPATWTVADSTEKDRNRTHRSVPQLNSMVHEVQCWVKQWTEEGSNMFVHKRLYQSHENNIGSAGDGRGGKLHMPRCIQDAYVTCATYFASTDRNKEMRLGIVEDRVATLLDEEGDPDDRGIETGDDEQFDDPFSTATLRVGNEGQTGGKLSKPRSVLDHLARVQALLIYQIIRLFDGDPRSRIMAESLIPVLSHWCKQMLDSALLSSQYVNSAISSTNAKTKANIEKKLNSDWNAWILAESVRRTWLVAGHMQCIYQLLSYGITACPGGLMFTTRAGLWQAESAYEWWAKCKGKDALFCPSLESGKYLLKPGVADDVDDFGRFVLKIIEGEERVNKWLPIS
Length2642
PositionKinase
OrganismTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.08
Grand average of hydropathy-0.254
Instability index49.39
Isoelectric point8.47
Molecular weight296016.70
Publications
PubMed=25676766

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
heme binding	GO:0020037	IEA:InterPro
iron ion binding	GO:0005506	IEA:InterPro
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0016705	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25362
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     482.08|     167|     767|     435|     718|       1
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  435-  631 (232.33/201.05)	YWGSLVrfrkrgRRLAEILLEKLRE.ATSSEFKV.NLQPLIERvSLLVRRLC.RENSpCLILPrswdrYQDIVASSLSDDS..........KEKAILQSLVLRNARVQRPGtccPARQRSPQEQVIKLLDASRDtcNMCALSSSCLALIpdRQELVSVLLrwaasPFRQSLVRVYIAVRLFRKwkrsgMDIDACI....FPF.LT.QTSMDQSTSS
 1216- 1401 (249.75/100.00)	YWLDLV......STMGQEAAEQLRQrAEKDFFSVaQSESAVEK.DLENERLClQENA.RVYLA.....IVDGLAYSIPEEGvpsvapvlveKMNTLLQKLFTMHMNVRNWS...ENRSRSSQEAMTLSLSGCEE..NFVFWLTSMLQMI..RIHRAAFDL.....PVSAGNQRLGAYVDLSRL.....LIIICCLalsrTPLgLTvQPRLDLSASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.79|      34|     767|     659|     718|       3
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  674-  709 (52.46/63.98)	SSVPVDIALLSHIpVARLPRH..LRNLRdTLMARAG..LP
 1103- 1140 (54.33/16.55)	SSVPCVVPLLSEI.IVRHPDDatLDSIR.TLMKNSPifLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.54|      35|     775|     205|     258|       5
---------------------------------------------------------------------------
  218-  255 (55.33/58.58)	RVPGP..NTNSDIQ..SH...ASKLSSQLKNHSSlqlLSSVFAAA
 1692- 1733 (53.20/19.45)	KIPGPflWSASRIPfvYHllrGSLIKSQRRFHNK...YGPVFRMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.86|      29|     775|    1009|    1060|       6
---------------------------------------------------------------------------
 1020- 1048 (47.56/56.26)	FAALMKKLLQSGSLQTVNSALPDSLVDFL
 1403- 1431 (46.30/13.24)	FLASAKEVRAGNTIQTYALDIASSLVDSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.98|      25|     684|    1477|    1507|      10
---------------------------------------------------------------------------
   75-   99 (44.23/21.92)	PSSRSADARSA..TTGSNPTRPAAVSG
 1478- 1504 (39.75/30.22)	PSSMSVSSPAAtlTPSNNPVNAATAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.57|      12|     685|    1785|    1818|      13
---------------------------------------------------------------------------
 1766- 1777 (24.22/35.40)	QPP..EGQADNLIT
 1803- 1816 (18.35/ 7.43)	QAPliEGHADVLIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     308.84|     101|    1125|     751|     861|      16
---------------------------------------------------------------------------
  751-  861 (156.52/160.52)	VKADISQWIRAAVS..EHYENGSA..YHPKM...YENNVEvSSLTQEeflVVRSTLEQYGDLSMLADilidaSNSDDVRLLTCAVDTlNRHFE...........CFTIIGALGDMFRSFYETF..LRMKAN
 1881- 2001 (152.32/124.36)	VKGEYHDWIRTLFQylKAMTIAAAprYWPVMqflFEKAIP.KSIKDD...AKRHQQYAYDRINRRLD.....SKTDRQDFITPFMKH.NPNFEnmsreeilssfSFVIIGGTETIATSLTGLFnhLAMPQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.33|      16|    1122|     366|     384|      19
---------------------------------------------------------------------------
  368-  383 (30.15/24.97)	VQQFTAGVISACGKPD
 1840- 1855 (31.18/11.44)	VNFFTMDVVRDCAKPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.29|      36|    2023|     131|     166|      21
---------------------------------------------------------------------------
  131-  166 (70.80/37.56)	SKP.PSPPPF.PVRPWTHTPARLSQVENEGISDNLRAR
 2207- 2244 (53.49/26.61)	SKPgSSKTTFrPVFTQVSLPATARKQANQGISNEKRDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.84|      19|      77|    2361|    2380|      24
---------------------------------------------------------------------------
 2361- 2380 (33.93/28.73)	IGSAGDGrGGKLHMPRCIQD
 2441- 2459 (34.90/23.74)	VGNEGQT.GGKLSKPRSVLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25362 with Med12 domain of Kingdom Fungi
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