Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNAQLSSALDGLENKLNSLLTSLTTPAAIGAPAAAIALLEADDVVSSALDTLRTHQANYAKILQLRTEAQNLEERIKTIVRDISGAEKEIAQVTGDDDDDDDDYEIDTDDEDEDNESETAMETDSENGGSIGQQKSSKKGRRKEVDYKLLLEFARRISKYNTQAAADATTGVLGTPGSTTKKLQEKQLEDAKMIDANGRDTSTQEQPGEQEEVTVGTVTKEATNWLEESADADRQYFMIPYPNEDRIRMGVMGQLQLAAVDGNVDPEKEAERMVQEAEGIAGVATSLADVQAQPQSLADEAGMAAKNPGAHAVARPAAKAAAPPAQPRPMLDLDLYDPEDDD |
Length | 342 |
Position | Middle |
Organism | Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.690 |
Instability index | 35.45 |
Isoelectric point | 4.25 |
Molecular weight | 36837.90 |
Publications | PubMed=25676766 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25355 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.63| 35| 42| 124| 163| 1 --------------------------------------------------------------------------- 124- 163 (49.30/47.19) DSENG..GSIGqqKSSKKGRRKEV.DYKLLLEFARRISkynTQ 167- 204 (51.33/33.31) DATTGvlGTPG..STTKKLQEKQLeDAKMIDANGRDTS...TQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 78.89| 23| 31| 277| 299| 2 --------------------------------------------------------------------------- 277- 299 (37.66/20.52) AEGIAGVATSLADVQAQPQSLAD 310- 332 (41.23/23.10) AHAVARPAAKAAAPPAQPRPMLD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GMAAKNPGAHAVARPAAKAAAPPAQPRPMLDLDLYDPEDDD 2) RQYFMIPYP 3) VDYKLLLEFARRISK | 302 234 145 | 342 242 159 |
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