<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25348

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGDATTNFSAITGFSVIHWRIYTEEANTGNPSSDIAPNSGYNILRHLSRLKDLEIQLRNSDCLVSCYPRRLGLWIFSPTPGFESLSPLARDPAAQGLKESTKLIIGTSSLKVSAFGSITAVDLIRSLSTDGFTSVAGNPGHPARSIGAGVNAPRSGDAYANSMAIYASFITAMAGTIGLQLVKRHNAIPLGARTFYTAVERSFYDNPIISDANVESIPALTTLRIELTQAGKIVVALHTVRQDGISRLKEPGTVEISTANIQNNMDVWLAPNGTVARLITVNMAQSAVFAPKQAKSEGAARQITEAKQRVWKATVLEWLNNVGLPVDHPEDEHWVEVEVSEPFYARLAAEHLRQMDDSQSSSPLKRILWPSRYCFRRSKIASSSITEKIPQLAYDGEEPLHFAETWLETATSRHEKPKDNSSNIQKRSQNEAISGTIKFEVPEKIESLARVIHYPDLQNASSVYPTPPDGALAPGINPMNSDTLGPDGQDIGLSHTPAGETPMKQQENVRKASSDNPSFEHMNVMEVGTGLYDTNDDDELFSGMNDKDFGSKGITDADFSFFDDDDDDEMNDFLNDKPEPEPAQHDVLQPNPDDLIDVPVAQAEIQGDQLAPEDNVFEQDEMQQSNDVEASALSTVDTKQPSPTPPNATLREPALPPLEHIINAPLSPTDIKQMLFSNKDKTGQDERRRASASSNPGFEKKQSRYNAISFKRGLTLDQKYANAGRFFFTANKDNNENSGTIPGIPTIGFPSWRRSGHRGSVDEVNTSRQIGSEQHMQRTDSASSDESSLDSSDDDSEDETSPFRLATLKRKRPLSEAEKSTTSSMEKLSITSEVESHVSKEDTSIFLGNFFSVFTDWSLVGYFSAKQSQVSPVTSRKEDQMQVAQLMVDQLTQSSLSHKIEGWESDPELEYEALGLPTFLDDSTSLGENDRLDLKSYVTIHDIAQTTTETPSARPTPQRREVKGSITKIAPSHLRIHRGRDFLEVLSTSMPFWETFGLEPASGRKDVSAYCICPEFAKEEADAFMTRLGLLYSGCNLGKHVKGDMFETIDEGIGLWNIAKGDSSYARTMQALRGLCEDLASALSKAPQTGENFVIYIINPFSHGAAFVDICSSFLHLFHKYVGDVDKNQDKSQLNELVLQIVPLDFVFSPTSMVVPPQSQYLNLALEVYTRCPPKDSSHSIIGYAPPVVLADAVPKAINFRVTSEHFSPFQEGRCLHVAISRSVDQRWISVAWTNNSGSCQISMSYCVRARGSNVNRIISEVRQEIWEATKDLMERTQTRWKVLLVRTEPIDQEEIDAWTGFAERYNQAKALPVELIIFSANIAPGLRLEPSTTHFSVNTINPLTSTPVATPYGGVPSPDQLGAATPASGGQGPTTTNYNTAMTPTDTPPVLAEADSDAVLIDACEESWAVILSHRLNNSAYLTDYKPALVSGYLLRRKGVNDSQGVTAMSLNLVYTSRPPALHEAVLREALINYRDLSTLARAKGTLHVQHNTLPWHIATAVKGQELLSFVL
Length1516
PositionKinase
OrganismTalaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Trichocomaceae> Talaromyces> Talaromyces sect. Talaromyces.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index49.09
Isoelectric point5.10
Molecular weight166880.57
Publications
PubMed=25676766

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25348
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     821.57|     261|     293|     332|     616|       1
---------------------------------------------------------------------------
  202-  299 (39.95/11.48)	.................................................................................................................................................................................................................VERS.FYDNPIISDANVE.SIPalTtlrieltqagkivvALHTVRQD.....GISRlKEPGTVEISTAN........IQNNMDVWL..APNGTVAR..........LITVNMAQSAVFAPKQAKS
  332-  616 (425.00/328.08)	PEDEHWVEVE............VSEPFYARLaaEHLrqMDDSQSSSPLKRILWPSR....YCFRRSKIASSSITEKIPQLAYDG...EEPLHFAETWLETATSRHEKPKDNSSNiqkrsqneaiSGTIKfEVPEkieslarvIHYPDLQNA...SSVYPTPPDGALAPGINPMNSDTLGPDGQDIGLSHTPA.GET.P.....MKQQENVRKA.SSDNPSFEHMNVM.EVG..T..............GLYDTNDDDELFSGMND.KDFGSKGITDADF.SFFdDDDDDEMNDFLNDKPEPEPAQHDVLQPNPDDLIDVPVAQAEIQGDQLAPE
  631-  911 (356.63/231.54)	VEASALSTVDtkqpsptppnatLREPALPPL..EHI..INAPLSPTDIKQMLFSNKdktgQDERRRASASSNPGFEKKQSRYNAisfKRGLTLDQKYANAGRFFFTANKDNNEN..........SGTIP.GIPT........IGFPSWRRSghrGSVDEVNTSRQIGSEQHMQRTDSASSDESSLDSSDDDSeDETsPfrlatLKRKRPLSEAeKSTTSSMEKLSITsEVE..S..............HV..SKEDTSIFLG....N.FFSV.FTDWSLvGYF.SAKQSQVSPVTSRKED....QMQVAQLMVDQLTQSSLSH.KIEGWESDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.07|      12|     286|    1165|    1177|       2
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 1165- 1177 (20.04/15.85)	LNLALeVYTRCPP
 1453- 1464 (24.03/14.05)	MSLNL.VYTSRPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.30|      49|     287|     966|    1031|       3
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  101-  156 (69.57/34.80)	KES.TKliIGTSSLKVSAfGSitavDLIRSLSTD.GFTSVAG.NPGHPARSIGAGVNAP
  966- 1017 (78.74/79.54)	KGSiTK..IAPSHLRIHR.GR....DFLEVLSTSmPFWETFGlEPASGRKDVSAYCICP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25348 with Med13 domain of Kingdom Fungi
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