<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25339

Description Mediator complex subunit Med15
SequenceMSHSMEKEWQNQVSSNDRQSIAVQIANALRIISPSISEAQLLAMASSFEKRAFERSSSKHEYINLCNKKAQQIREQIREQIHLAQMTQMSNMYPNANRPGNMTGVGAGAQRRTDGGAQAAGMNRLQAQGMPAQFAAGVNLTPQQQQQLLMQQAQLQLQQQKQQQQQAGKGNAGQQFPIQLTPQQLNQLYTRLAALMARNGSPPLTLQQMQSMPPVRLMAIYQKELGTLRSHQQQQLAQQQQQQTQSQAQPHQPGYGMGTSHTNAAASGFPAQMGETKASPSLQSFDQHSMPAANTANPPNRPAATRPPNYNANNAGFDMSNVPVPPQLLSQIPGLPPNLKVWREVVELGKTGRLNPEQMKIISVLFQKHMQFIIQQRQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQARYKAVPQAYQQQQQTASYTAANVGPFPSNSAAMQQLKMDKPEMSDMAALKRMENETAKMKQGPVNVQQNTQFQKMRAAGASQIPYTNPSDNMLKFPAGNSSQPNLQKSSQNPQASAQPNRQAQRDGGIYIVQQLLETGGRVGQPKLSMRIREMTEKVSRRFTRPPPLNLTSEQKLMASELTKGIYPMFSRTNQLIVLFYCITANDEATLQLIQLRHMFQLQLDGYPRGIFICAPQTLAKLKEKFESYFGFVKAHLMRLHNEVSVNKLTLQQALMQLGRTAAVNRPTQSSSTQPNQPVSANAAANNSYAPPVNQMASQAPHPVAPPYTNASLSNIPVNQTSDVYVEEPTIPLKHELKQEDLKLPPAKKKRAVQATGSSPQPKANAESPTIKSQETNDTSNSAQPVQVSASSATSTQNGIKEEPLSRAREEALANPLHYAIEAFSAIDADDEFLNSKTGLTPSSLRTPQCFITSTPDAMHSDVNSLSPANILLSFDGKSASDDPLELWDEFFNDDNLNTATTNIKDEKLPSPALSLPAQSPVIVSNDLLIPDADNADPWNELLGLKMKQSSPKTEASEPDPNSAFPETVGVWEVVI
Length1005
PositionTail
OrganismSchizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.05
Grand average of hydropathy-0.716
Instability index61.94
Isoelectric point9.17
Molecular weight111149.78
Publications
PubMed=21511999

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25339
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.01|      14|      15|     381|     394|       1
---------------------------------------------------------------------------
  383-  396 (32.51/ 9.79)	QQQQQQQQQQQQQQ
  397-  410 (32.51/ 9.79)	QQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     393.82|      74|      92|     140|     214|       4
---------------------------------------------------------------------------
  140-  214 (126.57/47.78)	LTPQQQQ..........QLLMQQAQlQLQ....................................QQKQQQQQA.GK...GN.....AGQQFPIQLTPQQL.........NQL......YTRLAAL......MARNGSPPLTLQQMQSM...........PP
  228-  291 (81.83/26.48)	LRSHQQQ..........QLAQQQQQ.QTQ....................................SQAQPHQPGyGM...GTshtnaAASGFPAQMGETKA....................................SPSLQSFDQHSM...........P.
  292-  337 (60.07/17.17)	.........................................................................A.AN...TA.....NPPNRPAATRPPNY.........NAN......NAGFD........MSNVPVPPQLLSQIPGL...........PP
  354-  479 (54.35/14.93)	LNPEQMKiisvlfqkhmQFIIQQRQ.QLQqqqqqqqqqqqqqqqqqqqqqqqqqqqqqarykavpQAYQQQQQT.ASytaAN.....VG.PFPSN..SAAM.........QQLkmdkpeMSDMAALkrmeneTAKMKQGPVNVQQ.................
  500-  577 (71.01/21.93)	..SDNML..........KFPAGNSS.QPN....................................LQKSSQNPQ.AS..........AQPNRQAQ......rdggiyivqQLL......ETG...........GRVGQPKL.SMRIREMtekvsrrftrpPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.65|      15|      27|     707|     724|       5
---------------------------------------------------------------------------
  707-  724 (23.84/20.99)	PVS...ANAAANNsyaPPVNQ
  732-  749 (22.81/11.11)	PVAppyTNASLSN...IPVNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      22|      30|     810|     836|       6
---------------------------------------------------------------------------
  780-  801 (35.57/12.87)	RAVQATGSSPQPKANA..ESPTIK
  813-  836 (32.07/22.34)	QPVQVSASSATSTQNGikEEPLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.50|      12|      25|     960|     973|       7
---------------------------------------------------------------------------
  960-  973 (18.21/16.12)	PDADNADPwnELLG
  988-  999 (24.29/12.55)	PDPNSAFP..ETVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25339 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTLRSHQQQQLAQQQQQQTQSQAQPHQPGYGMGTSHTNAAASGFPAQMGETKASPSLQSFDQHSMPAANTANPPNRPAATRPPNYNANNAGFDMSNVPVPPQLLSQIPGLP
2) LAQMTQMSNMYPNANRPGNMTGVGAGAQRRTDGGAQAAGMNRLQ
3) LMQQAQLQLQQQKQQQQQAGKGNAGQQFPIQLT
4) QQTASYTAANVGPFPSNSAAMQQLKMDKPEMSDMAALKRMENETAKMKQGPVNVQQNTQFQKMRAAGASQIPYTNPSDNMLKFPAGNSSQPNLQKSSQNPQASAQPNRQAQ
5) QRQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQARYKAVPQAY
6) RTAAVNRPTQSSSTQPNQPVSANAAANNSYAPPVNQMASQAPHPVAPPYTNASLSNIPVNQTSDVYVEEPTIPLKHELKQEDLKLPPAKKKRAVQATGSSPQPKANAESPTIKSQETNDTSNSAQPVQVSASSATSTQNGIKEEPLSRAREEA
226
83
149
424
376
689
336
126
181
534
420
841










Molecular Recognition Features






MoRF SequenceStartStop




1) PLELWDEFF
2) WNELL
913
968
921
972