<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25337

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVIPDIPHITQGLFPLSDIVDAFSRNTLKQLVQLADILPSLSNVDKKRQILQWLIQYRGYAIRILVLSRWAGVAPLVNRCIDVVAYLQGQKFCYQNLIYALQDIRYQLSFARVRNSDLLTAVDVLSSGTYPRLLQTPTSNAYLVPDEEISAKEALKALDAIHATLRLRLHLHETIPRPFRDYEIRDGRCIFVVPNEFSVALSTTSDNIRPENLAFQWFLVDFDFLLPSTSPSTITPERYKNLIEQHLNEQLAVALLNKLPALPLVYDILHRCCLYLRLNLLHQQLEALSRDSWAGHLIGTLNEQTSTLRIKYWPKLKISKDGKVVTPDFEIIISVLTQEPTAYERLLSTRTSSAEYDHSKLNIVWQHDGTSEPISIEEPFESQDLLMLVTKKHAAIFFERIQSNMNKSILSELREDGLVLQMMKHRILLKVNSITGRLVLLDEQQRLAPARYLRAAENTIAAKPDLAAQTLNRLRLFCIQAQMIELSQCARLHVVRGYLPPAYLTFTRLSWHRPDHSVWMLAFHVETLHWFMYLTSATGKVLFSQRVHTTGDALSIQSFSRLAHLVHLRQQLYEIQLVCESKHMRYSYMLTPPGASFQDTFSEFVQTSLLCIEMPEKYGVLYPMVFVRASENKLVFDGRIHYRTPQGKKETSGDCTVDWRVGRFTVQSRNFDEFEKQWVGLSKLAMLAVTTAFEVVEVTLHYVKFRYGDTETFQVSVLENDSFKIQFFNPQSCFHMIAHLLQGVLSDSRNDVRTLRNILDRTHGILIAQSMGFIVLVRSLRSFRILLAPNHGLQVTLSRSGAVIQDLSIAKCEPSKNPADDEALIKWAPCAWLNSVWEGDMDDDELNGQVEASPESCLLRLSKDADLSAVIKHILMLTCKLKAS
Length884
PositionTail
OrganismSchizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.09
Grand average of hydropathy-0.056
Instability index43.19
Isoelectric point7.62
Molecular weight101126.69
Publications
PubMed=21511999

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.37|      18|      18|     761|     778|       1
---------------------------------------------------------------------------
  761-  778 (31.41/22.78)	RTHGILIAQSMGF.IVLVR
  781-  799 (26.96/18.42)	RSFRILLAPNHGLqVTLSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.84|      20|      24|     191|     211|       2
---------------------------------------------------------------------------
  191-  211 (31.29/23.67)	FVVPNEFSVAlSTTSDNIRPE
  218-  237 (36.54/23.12)	FLVDFDFLLP.STSPSTITPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      18|      13|      24|       3
---------------------------------------------------------------------------
   13-   24 (21.09/ 9.91)	LFPLSDIVDAFS
   31-   42 (19.66/ 8.84)	LVQLADILPSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      14|      18|     646|     662|       4
---------------------------------------------------------------------------
  646-  662 (17.68/23.53)	QGKKetSGDCTVDWrVG
  667-  680 (26.44/18.05)	QSRN..FDEFEKQW.VG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.13|      85|     216|      67|     175|       5
---------------------------------------------------------------------------
   66-  165 (137.98/126.12)	V..LSR..WAG..VAPLVNRCIDV.VAYLQGQKFCYQnliyalqdiryqlsfARVRNSDLLTAVDVLS..SGTYPRLLQTPTSNA.Y......LVPD.....EEISAKEALKALDAI......HATL
  285-  396 (99.16/64.89)	LeaLSRdsWAGhlIGTLNEQTSTLrIKYWPKLKISKD...............GKVVTPDFEIIISVLTqePTAYERLLSTRTSSAeYdhsklnIVWQhdgtsEPISIEEPFESQDLLmlvtkkHAAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.79|      11|      18|     547|     557|       7
---------------------------------------------------------------------------
  547-  557 (18.54/12.24)	VHTTGDALSIQ
  566-  576 (19.25/13.00)	VHLRQQLYEIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.63|      24|     198|     257|     284|       9
---------------------------------------------------------------------------
  257-  284 (38.42/34.22)	NKLPALP.LVYDILHRcclyLRLNLLHQQ
  458-  482 (36.20/20.88)	NTIAAKPdLAAQTLNR....LRLFCIQAQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25337 with Med14 domain of Kingdom Fungi
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