<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25331

Description Mediator complex subunit Srb8
SequenceMHQSFSNSSIGRNDATFHSNGVSVVESHNAATSSMDVCYYKHEFDAGAFESRKVQQGHFYVAEVADEHTSSSKDIREKITSTQALGNVKQFLAPLLHEKYAEEPNFEYSDFKPPPRVTLQESKRASWFQDLANHLVPLSNLAKRIPHGIWGKDILRSCMSYFVPINRAAWFIKCVGVNEARAFLRKNPNNTVDDWYANWTASVCALLSEIVSSMVDMKQRSLQAKQFSYVLQIITYLIQNDLLNETHMLQHVLRFLYESNASSLPKAILVLEFFWCRIMDKPQIAQIGVILILDFLKILKSSFYGLPAELKSSFDQRLNLLLFRLAYKRPNCYFMPDQWKTIELQLKYAWRRFPGSANVYAVIHERNSRSHRLINPLNKRFRFLEILNSLNPTSDWKLVTSDLLKLLPTDETLHLIIKWCVGINHMYLVEKPYYTAMLFRYADLNIQTLQENILHFLFNFDFSHPNEVTALAVLLDELHQLHLFSFSTYIKLLAAKGYLRDSMRNTEVVNKHCQFLMQYPVHNLRRSIRTAVHNILIRNGVKIHWEAVDQYIQQFRKNPKTFHFADDELYSIVSLTLSRLLELIGDSTMQAYFLFILCWRYSALRVIDRAVPIMRNNGIMRLSLLILLVKGLTLTPILRKFIIEMSTKDEILSEAEKAVLIQLDSLYKLDLNVNYTFVIPLFVVQQNYMYERVQNEPSCLKKFMLRPNIQAEELVEYLTDTLEHTIKDEEIIFTNTCLQCLKVMSNASLISQKIHNLVRKWLFTNPCEDMRLNKLLHIARARLISIEELSILLNELLTADTVGEVGKELCFKIFSYRLSRTDDGSKEWYSYSEILQLVRCSIDMQNIIRKAISGFSHNRMFMLNTLALLYTLDFETSVSLFSSKEELRDIVCTFIPQLCTIDIRESFRLALEKCDLFYTTLYSLWLYTLDERQLSRLSFDFLFDSLAATFPRYRPELWQNMCLGLSFCKDLFQEVILRTLSTFKALPQEFLSDVCSISAWILKHNPDKHFLNQLSQMFPSRMKLVYSWCKTVGNDETKQLELQSWVMLFIHLLLHFHSYLKQPNLIHQLNTFAQIPFIFDNPHIIDILTDAKTFLLQSEKMNDKAEQAKSLAPWEDIEGLTLQGKTPYTLQQFDPKRTTSQLFFWTLKNSSEH
Length1153
PositionKinase
OrganismSchizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.12
Grand average of hydropathy-0.084
Instability index43.97
Isoelectric point8.16
Molecular weight134772.64
Publications
PubMed=21511999

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25331
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.13|      43|     130|     724|     853|       2
---------------------------------------------------------------------------
  724-  771 (68.15/25.47)	HtikdEEIIFTNT..CLQCLKVMSNASLISQK..IHNLVRKWLfTNPCE.DMR
  857-  904 (61.98/107.61)	H....NRMFMLNTlaLLYTLDFETSVSLFSSKeeLRDIVCTFI.PQLCTiDIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.63|      10|      21|     454|     463|       3
---------------------------------------------------------------------------
  454-  463 (20.68/11.39)	LHFLFNFDFS
  478-  487 (19.96/10.71)	LHQLHLFSFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.15|      41|     139|     154|     195|       4
---------------------------------------------------------------------------
  124-  150 (38.89/16.02)	.............RASWFQDLANHLVPL.SNLAKRIP..HGI..W
  154-  195 (71.14/38.24)	ILRSCMsYFVPINRAAWFIKCVGVNEAR.AFLRKNPN..NTVDDW
  298-  339 (60.12/28.45)	ILKSSF.YGLPAELKSSFDQRLNLLLFRlAY..KRPNcyFMPDQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.85|      27|     452|     555|     599|       7
---------------------------------------------------------------------------
  560-  586 (45.81/52.56)	KTFHFADDELYSIVSLT..LSRLL..ELIGD
  774-  804 (34.04/ 6.25)	KLLHIARARLISIEELSilLNELLtaDTVGE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25331 with Med12 domain of Kingdom Fungi
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