<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25322

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHPASFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVSEQSHAANFISSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTKNSFPTPASSVSGHPVNATSEDVDQGRKSFNIGIQDSAENSGAGAAQQPAQQQTQHRPTDHDRQSLQTDRTNDFAAGQGQHSTDPDAMDVDTDPTRRANTLSLDLDSLQKELTSAFHLCKRSPIVTGPDPSVDLVSLYGLGPIANSVARTDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRHMTLWPEEEWQNQKVHGKAIKVADMDSALQNLQSRAMQMEPGPIPNNDFWEDILGETGKKAAAAPSAGRSSTQSYAATPQAQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKVLHSHGNLLC
Length430
PositionHead
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.04
Grand average of hydropathy-0.914
Instability index57.50
Isoelectric point6.60
Molecular weight46334.36
Publications
PubMed=18820685

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25322
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.67|      20|      26|      14|      39|       1
---------------------------------------------------------------------------
   14-   39 (33.96/22.02)	PP....SPSSPAGSLkenhrlPISSEHIP.Q
   44-   67 (25.48/ 7.81)	PPlmsvSEQSHAANF.......ISSHTSPnQ
   72-   90 (35.23/13.16)	PP....NISSPPSSA......PMSTQ.VS.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.80|      21|      22|     146|     167|       2
---------------------------------------------------------------------------
  146-  167 (35.72/24.59)	AQQQTQHrPTDHDRQSLQTDRT
  171-  191 (40.08/23.13)	AAGQGQH.STDPDAMDVDTDPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.83|      25|      26|     198|     223|       3
---------------------------------------------------------------------------
  198-  223 (39.58/26.30)	SLDLDSLQKELTSAFHLCKRSPiVTG
  227-  251 (43.26/24.64)	SVDLVSLYGLGPIANSVARTDP.VTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.28|      20|      20|     263|     282|       5
---------------------------------------------------------------------------
  263-  282 (34.29/22.39)	GKLKGLGLAGRNKPHKQEI.G
  285-  305 (34.00/22.14)	GSLRHMTLWPEEEWQNQKVhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      14|     386|     396|       6
---------------------------------------------------------------------------
  386-  396 (22.39/15.85)	DDNSFAGYGEG
  402-  412 (23.44/16.98)	DDPGFYSNGEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.89|      14|      19|     350|     363|       7
---------------------------------------------------------------------------
  350-  363 (23.45/10.73)	AAAPSAGRSSTQSY
  372-  385 (26.44/12.92)	AERPRPSRGRKRHY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25322 with Med19 domain of Kingdom Fungi
Unable to open file!