<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25321

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMLPDRAIPEQWRTFLHQCLANRIDIDEFTDLSGLMFSRSPVKENELLDLLLEARASSSVTWDPLLPLYVDGLCKVGRVKSSSALASLLKHSSVLDGSGSGEGEGEGQSSPPKSKKQKPSTLMTDIKVIQDVMVFISTGSIPKTVIEAADIYSATVDWILAVVAWHNNSMGASQHTGGLMGSPDAVSLFESLGILLAALSGTSKGLEVLSSDYNQGLKTKLGQALSSYLPLCIDVSLPLRHRLEELQKVFHLYPGQPSKTLEGPGIDGVNVNALQLESSVMDAPVVNTRAGLYVYINSMVVGRPLVDDTILINYLTNRYQGHNDVLIEEIITAAFDVLSNGVYRNESSRTMLLFRSFLVNKLPAFFAAISAASMVPISMEMCISHALSRLDPNAFPSFSQMFSMQGSSVLSDARQEFLFACASHKLIRESSIEQLLGENPMQTLSSGGPYVKDDLVSQINNNHERAEQLIGEIESMEGNAGAIVGAVVEVMHNLCNQKETMTLKNICNSLSRRPQTLDVMLLFRTTKQVLQPLCAVLDSWKWDEDQGENQPVYDEFGSILLLVLAFKYRYDLSPSDMGISSNDSFLLKLLDRGACSQKLSDLSEKQNKDLGAWIGALFIAEGISEETMSTCSPHEFYMLVTTLFDQSLGAYLLEPFLLPSLVVALTWLGNHIWESETDKTDPTIPIKTLHSLVKPSSISGEAQAIHQTVLNITGCPLEEQLKNVRTRNTSRTDIKPILDALEPYISFRRVGSCRRSELDTWTSHPTGGLIASIRATLQSLVLWSANPGISMAPHAYTHRQVLAGIRMLGATRVLSAIIDEVKQQTEAGSGHIALDIATTMVCAPMTESFAVDQNNYHPVDPSKEPLPRCAILTLRDALALQHENVPKISESDPLRAEVVVRLSRRVNMLMAPPSQVSNIDVSNIIQNMHLGVEGQEDRMDLEPSAADVARNTVNEDDPDNINQMLDKAAADAAAAGMDGGIGVGQDMGLDSGAGMDAIDDVLNAADMAVGNPEFLDLDMEGMF
Length1022
PositionTail
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.06
Grand average of hydropathy-0.046
Instability index44.40
Isoelectric point4.84
Molecular weight111436.84
Publications
PubMed=18820685

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25321
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     583.73|     182|     208|     420|     627|       1
---------------------------------------------------------------------------
  420-  535 (143.41/94.59)	..................................................................................................................................CASHK..LIRESSIEQLLGENPMQTLSSGGPYVKDDLVSQIN..NNH......ERAEQLIGEIE.........SMEGNAGAIVGAVVEVMH.NLCNQKETMTLKNI.CNSLSR...R......PQTLDVMLlfrttkqVLQPLCAV
  536-  746 (221.62/178.14)	LDSWKWDEDQGENQPVYDEFGSILllvlafkyrydLSPSDMGIS......SNDSFL..LKLLdrGAcSQKLSDLSE..KQNKDLGAWIGALFIAegiseETM..........................stCSPHEfyMLVTTLFDQSLGAYLLE......PFLLPSLVVALTwlGNHiwesetDKTDPTI.PIKtlhslvkpsSISGEAQAIHQTVLNITG...CPLEE..QLKNVrTRNTSRtdiK......P.ILD..........ALEPYISF
  757-  964 (218.70/134.72)	LDTWTSHPTGGLIASIRATLQSLV...........LWSANPGISmaphayTHRQVLagIRML..GA.TRVLSAIIDevKQQTEAGSGHIALDIA.....TTMvcapmtesfavdqnnyhpvdpskeplprCAILT..L.RDALALQ..HEN.VPKISESDP.LRAEVVVRLS...........RRVNMLMAP.P.........SQVSNID..VSNIIQNMHlGVEGQEDRMDLEPS.AADVAR...NtvneddPDNINQML...............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.66|      24|      25|     970|     994|       4
---------------------------------------------------------------------------
  970-  994 (38.67/28.32)	DAAA...AGMDGGIGVGQDMGLDSgAGM
  995- 1021 (37.99/22.52)	DAIDdvlNAADMAVGNPEFLDLDM.EGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.51|      49|     142|      33|      81|       5
---------------------------------------------------------------------------
   33-   81 (85.99/56.91)	GLMFSRSPVKENELLDLLLEARASSSVTWDPLLPLYVDGL.CKVGRVKSS
  177-  226 (77.52/50.53)	GLMGSPDAVSLFESLGILLAALSGTSKGLEVLSSDYNQGLkTKLGQALSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25321 with Med5 domain of Kingdom Fungi
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