Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MGEDATPQELPSFTSADRIRQLNEMDKDVTKLLHSAGLAIQALTNAKPDPSAVASDGSLDSHKMRFKEASAKYFALLSSADVTLRRQVYSLEESSLVGPEKGSRAGDTKVGARNEGVAGAKSRAPNSLDISRLNSRKDTVGKDKEAELWAAAREFVEQMQNPSETSKDSRPANESEDMQVD |
Length | 181 |
Position | Head |
Organism | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.750 |
Instability index | 34.42 |
Isoelectric point | 5.22 |
Molecular weight | 19612.46 |
Publications | PubMed=18820685 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25320 No repeats found |
MoRF Sequence | Start | Stop |
1) HKMRFK 2) LDISRLNSRKDTVGKDKEAELWAAAREFVEQMQN 3) QELPSFTSADRIRQLNEMD | 62 128 8 | 67 161 26 |
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