<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25318
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNALVQSALTDVESKLNALLTSLTTSPTAAGAPAAAVALLDSDDALTSAIETLRQHQENHAKILRLRNEVQQLEDRVKGIVGDIEGFEKEVRTACGDNGDSDSDFDSDSDDDLGGKNSLLRGIKEIDYKLLLDFARRISKYNHEAAADAATGVVKRQEQGKPLADKDVTMTGMNGEQPTDEGAEPVASVTKNATQWLDDSANVTRQVYMLPYPMEERIRMGLMGQIQLSVGDDPEKEVERLLRESEGLGAAEPPAAVEPAESTKQADEAARAAAQAGSSAAGMPRAHAPKAMLDLDLYDPEEDED |
Length | 305 |
Position | Middle |
Organism | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium>
Penicillium chrysogenum species complex.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.554 |
Instability index | 44.76 |
Isoelectric point | 4.43 |
Molecular weight | 32746.84 |
Publications | PubMed=18820685
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP25318
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.28| 24| 66| 41| 64| 1
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41- 64 (41.06/27.74) DSDDALTSAIETLRQHQENHAKIL
108- 131 (41.22/27.88) DSDDDLGGKNSLLRGIKEIDYKLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.31| 19| 148| 73| 91| 2
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73- 91 (33.33/23.20) LEDRVK.GIVGDIE.....GFEKEV
214- 238 (24.98/15.71) MEERIRmGLMGQIQlsvgdDPEKEV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.89| 24| 66| 183| 206| 3
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183- 206 (41.46/23.71) AEPVASV.TKNATQWLDDSANVTRQ
251- 275 (35.43/19.37) AEPPAAVePAESTKQADEAARAAAQ
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|