<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25317

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNVNIEGSVRRPGVNEARNGTPNADKPGHLSDINGSVYVNGASSGIAVSNQYPSTLTDETAEIVPTLPFKLPHITQGFFPFGTLVNRSVQECWNELSELIAELATIQVPASGSSMPTNGKPAGNQSSENVHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTAVEVLSKGRVASLPDLGYKPPTPLTARATLKKLLKLNRIISVRLAIHDSVPPPLRNYRVHDGRVTFTISGEFELDLSVAEESKASQFFFVDIRFLFSPSSPIPKGRIFNELDGKINDLLRDDGLMGCFQFLHGLVLTNKINILFKQAVDLSRGLWADALRIELLHRTLVVQYWPQRSGPKSWLEIGVKSGHRSGSSSDPKPGMSHVGFRWMRDGQQVSSDAIRFNPSDLSMELILRSVIALHTSHLLSTAFATLKKHILFSNHTLSLQAQLSLTEPGDCRLDVQLTASRSLRVSIEPMSGSITLCGTPHVLERLDSDRGLYKSSIEEILSRIARLRCITAVDEIDSGIKALGLEPVNQRVLGLDPRKLFPPGVMRAAFFTHRLWNRHWVAAATSSMDGDRWWLVQLRPTGTAKMGPSYSIGDPSMSLPQAHVVSETLIPAQKRLNYTTCAELVHGLTGILAIHANARYLADLPAMHFWPSLKELQLETNLTVPDLLFNYSSSTLPPAFRITLPFGVKKQSQFKEMIRLVFHGIDNQSRSVVMMAHGTLKTRIKSLVPLVSSIDSSLIVEDKGAGFALRLLVPAGHSVIACLFELLQRLECVLSILQSLILKGMEPRSLSLSRIDFAYGPENKFSALFDISSKGPSLSDYVDVENAISKAKPLFQLKLGIKFESSSPHRRIQEPLTVALNQRFTEAGVESTLHLLATTLPLLRSLDQITQLNQTDLSIVQIIVRKPTVYMIHYPRLRSRFHLSAVMHQDRLVWMLRDANGMDQSGRGQVAAFVQEKLYQSKGDGWNGLGDGVVASINKVGNLILELHECLNAPHLQLDKVEVKTEQIPKQLPIKGPTSAAPLAKRNTDVITID
Length1069
PositionTail
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.07
Grand average of hydropathy-0.097
Instability index47.38
Isoelectric point9.32
Molecular weight118438.19
Publications
PubMed=18820685

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25317
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     435.57|     123|     218|     350|     482|       1
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  140-  250 (113.29/72.73)	................FAHAKRAEFI.KLLVLSQWSRQAADVSRL...iDIqGfIRTRHQSYDAA.....L..QYVG........EVKRDLVRAqvaNP.DLktAVEVL..SKGRVA....SLPDlgykpptplTARATLKK.LLKLNRIISVR
  350-  475 (206.90/169.92)	LFKQAV....DLSRGLWADALRIELLHRTLVVQYWPQRSGPKSWL....EI.G.VKSGHRSGSSSDPKPGM..SHVGFRWMRDGQQVSSDAIRF...NPSDL..SMELI..LRSVIALHtsHLLS.........TAFATLKKhILFSNHTLSLQ
  575-  670 (115.38/76.48)	LFPPGVmraaFFTHRLW.........NRHWVAAATSSMDGDRWWLvqlrPT.G.TAKMGPSYSIGDPSMSLpqAHVVSETLIPAQK......RL...NYTTC..A.ELVhgLTGILAIH...................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.02|      34|     234|     300|     341|       2
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  303-  341 (52.31/57.19)	FSPSSpiPKGRIFNELDGKINDLLRDDGLMGCfqfLHGL
  878-  911 (58.71/36.09)	FESSS..PHRRIQEPLTVALNQRFTEAGVEST...LHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.42|      73|     648|      53|     138|       4
---------------------------------------------------------------------------
   53-  138 (108.00/108.34)	YPS..TLTDETAEIVPTLPFK.....LPHITQGFFPFGtlVNRSVQecWNELSEL.......................IAELATIqVPASGSSMPTNGKPAGnqssenvHkKLRLL
  685-  787 (104.42/69.43)	WPSlkELQLETNLTVPDLLFNyssstLPPAFRITLPFG..VKKQSQ..FKEMIRLvfhgidnqsrsvvmmahgtlktrIKSLVPL.VSSIDSSLIVEDKGAG.......F.ALRLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25317 with Med14 domain of Kingdom Fungi
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