<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25315

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMASQDASMEEILWRSPPHVQMMGGFLHSNNILFYFAESPFFDSTSNNASLAIQANYNDAFRHFVETREAFEARLKTMQGLEFMVSYDPLQAAAQTDNRFAHEPSNIWVIRKQNRRKRSGMDDEVTVISTYFVVGDCVYMAPSVASVVGNRILSAVTSLTQLMKSAATLPTFTASHGHTYLPPGVRSKESAGTSQASQSKEATPMPDASFPTTESSQSTSKSSLGGSTTSSAYQDTRSLAESFSLLTRYGDEFMDENPLVGEPGSFILSRTGGEATGSAAKAAPKIAAAAPTGTPSALPVRASTPQVRVETPGKVSEKSTSPPSSAGDKGKRKKSRVVS
Length338
PositionHead
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.08
Grand average of hydropathy-0.393
Instability index54.16
Isoelectric point7.83
Molecular weight36249.05
Publications
PubMed=18820685

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	PIRNR:PIRNR013286
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25315
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.58|      14|      18|     304|     318|       1
---------------------------------------------------------------------------
  304-  318 (19.90/17.34)	PQVRVETPGKvSEKS
  321-  334 (24.68/16.26)	PPSSAGDKGK.RKKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.98|      10|      18|     189|     198|       2
---------------------------------------------------------------------------
  189-  198 (17.48/ 7.74)	SAGTSQASQS
  208-  217 (17.50/ 7.75)	SFPTTESSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.72|      19|      20|     232|     251|       3
---------------------------------------------------------------------------
  232-  251 (29.75/24.39)	YQDTRSL...AESFsLLTRYGDE
  252-  273 (30.97/20.16)	FMDENPLvgePGSF.ILSRTGGE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25315 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEFMDENPLVGEPGSFILSRTGGEATGSAAKAAPKIAAAAPTGTPSALPVRASTPQVRVETPGKVSEKSTSPPSSAGDKGKRKKSRVVS
2) GHTYLPPGVRSKESAGTSQASQSKEATPMPDASFPTTESSQSTSKSSLGGSTTSSAYQDTR
250
176
338
236










Molecular Recognition Features






MoRF SequenceStartStop




1) AAKAAPKIAAAAPTGTPSALPVRASTPQ
2) LLTRY
3) TSPPSSAGDKGKRKKSRVVS
278
244
319
305
248
338