<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25313

Description Pc20g07440 protein
SequenceMIPHSSAGGQPWGHPLRTFNGGPGRVDNAQMLAQYDQPDRPASLPQPPIRQPAVVDLTAGGPESQDREPPPKRPRLDVPSGTNTSDTGAGVGETRSTPGSAISRPAVSWRGRPVWSFQAVVSETPSNENRSDGAGPKPPSPPPLPAQPWMNNFVAETEGSAAITVNERPDSRIVTSRLISVLEPADFTPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVREWTTNVQQFVEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGSIPIWLLMLGIYWNSIMRYRRRGRRLAELLLQKVRQATEAKLTQLQPLIDRLSRFIKKLVLNHTSSMILPTCWENYKQQVSSALDLDNEVEKALFQSLAERNARVQRPRHSKQTTQRSPHQRIVQLLDSIRSAQDLSSTFSYLEVFDDKAILVSKLLEWLSTPFRHGLWRVYIGVRLLRKWKLSGVDIDSHILAFLSRGQNNQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTNGSTSAEERKAKDLPIDIGLIAQLPVARLPEHVGNLRSTLLTRTGLSASEENAAIDSAKDTISQRLPGIFGVNDSASMSLDSLSSDLPWAVKAEVGQWLRGAIAEHTRSAESTNRGANPPGIASVVSALTPAEFYTVRDALESFGDISMLADVLKFASTCGDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKKVGMPSLDLIFSLIELGLRIPSELNTVSILRQDLSRMENKSIMAASSPVSGHIPDGFGGVDPFFREKLDQLLQSGNVMDEPTLDAIFNTLIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDGVLARWVCGHLRSPERTVLLRILPPLIGVGCVTIRAFLALAKRLTLSTPATVPNADQLPADIVQLLVPGDQDSKFFDLVSYRFQLAQQEFLSKNSEEALKIACDAASSKADDGPSAGHSKLERSIVMLLRDLLVRHPECAARNGMQKLIDQYPAALSIVQKALDLLLGVESQSDGNSVLSKVEKLARMTDDFSLPFCQLKLQVLFHADSGSEDRNNIVDAMFKTAVSDCRAQRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLLEEPIGGIPDSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDSLLHKIITMHNSTAAKGVTNTDRSKFERALAFWFSALLRIIVLHRSAFVQPPAALKVNPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPPPAEGYRPCPGILLQTHALDVAASLIDIFPDEVRHQCARFLKEKCPSFVPFQNDSRFLYLLGPMTDQYPANAQQVSAPSPAASGSTPTPTPGLFGIVGSSPAQQSTAATSGLSTIPADLNCIANRLRLQHRGRVVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1560
PositionKinase
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index45.98
Isoelectric point8.58
Molecular weight171750.24
Publications
PubMed=18820685

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25313
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     308.77|     100|     279|     324|     602|       1
---------------------------------------------------------------------------
  289-  397 (165.49/276.93)	LRRLSRTIPHGIRGKILLDQCLGKWIPVARAVwlakcvganEIRAFKRKGTSGA.LAVG....LEAKWVREWTTNVQQFVE.....GVFAAPKSS.DWKAK.MTYAVGLTARLFSENLLDH
  571-  684 (143.29/32.86)	LEWLSTPFRHGLWRVYIGVRLLRKWKLSGVDI.......dsHILAFLSRGQNNQkLNMDqiyhVVSELVRSQTFSVGRYLQwlmarGVTNGSTSAeERKAKdLPIDIGLIAQLPVARLPEH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     380.50|     104|     280|     781|     890|       2
---------------------------------------------------------------------------
  686-  768 (56.39/25.37)	................................GNlrSTLLTRTglsASEENAAI...DS.....AKDTISQRL....PGIFGVndsasmSLDSLssDLPWAVkAEVGqwLRGAIAEHTRSA..ESTNRG
  781-  890 (153.99/103.35)	LTPAEFYTVrDALesFGDisMLADVLKfASTCGD..STVLASV...ADTTNCHF...DSLCVIGATTDLFRRLIDAYAGIKKV......GMPSL..DLIFSL.IELG..LRIPSELNTVSILRQDLSRM
  905- 1000 (133.75/73.53)	HIPDGFGGV.DPF..FRE..KLDQLLQ.SGNVMD..EPTLDAI...FNTLIKHLesdDGHANLSA.NDTCRYL....AQLRSF......HPKHF..DGVLAR.WVCG.hLRSPERTVLLRIL.......
 1123- 1165 (36.37/13.28)	......................................................................QKLIDQYPAALSI......VQKAL..DLL......LG..VESQSDGNSVLSKVEKLARM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.41|      33|      43|      77|     109|       3
---------------------------------------------------------------------------
   77-  106 (48.19/23.10)	................DVPSGTNTSDTGAGVGETRSTPGSAISRPA
  107-  146 (42.79/19.68)	VSWrgrpvwsfqavvsETPSNENRSD...GAG...PKPPSPPPLPA
  188-  225 (49.43/23.88)	TPW.......tgnhpeDVLS.EQTAKQGYYDRTQVSQNESNTARPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.38|      28|    1318|     157|     187|       4
---------------------------------------------------------------------------
  157-  187 (39.43/34.45)	TEGSAAItVNERP..DSRIVTSRLISVlePADF
 1478- 1507 (44.95/27.68)	TPGLFGI.VGSSPaqQSTAATSGLSTI..PADL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.24|      12|      35|    1294|    1305|       5
---------------------------------------------------------------------------
 1294- 1305 (22.10/16.65)	SLLHKIITMHNS
 1328- 1339 (20.15/14.48)	SALLRIIVLHRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.90|      31|     499|    1008|    1054|       6
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 1017- 1047 (51.45/54.33)	LAKRLTLSTPATVPNADQLPADIVQLLVPGD
 1353- 1383 (52.44/20.77)	LHEQLRLLTSIFCIALSRLPGDVLRLFPAAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.66|      11|      26|    1242|    1252|      12
---------------------------------------------------------------------------
 1242- 1252 (21.29/11.19)	LEEPIGGIPDS
 1269- 1279 (19.38/ 9.53)	IEELASSIPDS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25313 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANAQQVSAPSPAASGSTPTPTPGLFGIVGS
2) MIPHSSAGGQPWGHPLRTFNGGPGRVDNAQMLAQYDQPDRPASLPQPPIRQPAVVDLTAGGPESQDREPPPKRPRLDVPSGTNTSDTGAGVGETRSTPGSAISRPAVS
3) PVWSFQAVVSETPSNENRSDGAGPKPPSPPPLPAQPWMNNFVAETEGSAAITVNERPD
4) PWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALY
1458
1
113
189
1487
108
170
227










Molecular Recognition Features






MoRF SequenceStartStop




NANANA