<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25305
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MAESFTLPLRSIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIAEEEEKDGLEEVEESDQDAADLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVHPPPKPESTTKDVSAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPIERQSLGVQYGFIEAAPVFRDRGLASLRRAEDGALSLDEGLIPPKARFVRVRVIQDGRLSGSSKPMRSSFNGDGTIEDRILQARDTVYEDELFHELVREARAIASFGVTTRQNLIQIPASDNLEILLDLVDTDEDTSEHEHSISQQGISIAEGLAHTIRILLAYAHRQNLRRRTQLPLPLTPKTRPVPEHQLIRPALAYIKHMSQVRWLQSLLEDLFGVLKSAGLEPPAYTARIFSTGMQSHSSPAPAVENLVGQFLTPLLSTFNGKILTPRGSFSIAIHTNLSSPPFGTTFEVSFNMPKYPDLESPGKLSHREEVEAAITHLLLLDVVFTISSDSSLKHECDRDPAKRTWEAIYPQHGELLIPTPKSNSGKRKKMKIVLSRHELSLEIYTVRCIDGTGRGNWEMPSYHSMPHTWKPSPIAGPPKPPSLMDFVSKMSRS |
Length | 644 |
Position | Head |
Organism | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium>
Penicillium chrysogenum species complex.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.420 |
Instability index | 53.76 |
Isoelectric point | 6.18 |
Molecular weight | 72232.23 |
Publications | PubMed=18820685
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP25305
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 127.36| 43| 179| 204| 270| 1
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22- 76 (53.59/22.84) LPVEIAQINNQWGsFREVnEDVLRNKiaeeeekdGLEEVEESDQDAADLDstERL
204- 246 (73.78/82.86) LPIERQSLGVQYG.FIEA.APVFRDR........GLASLRRAEDGALSLD..EGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.50| 11| 39| 150| 160| 2
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150- 160 (20.77/13.12) DVSAV.SRGWRI
190- 201 (15.73/ 8.33) EVLAVkDKGWKV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.86| 14| 33| 363| 376| 3
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363- 376 (25.04/15.80) IRILLAY.AHRQNLR
398- 412 (21.82/12.93) IRPALAYiKHMSQVR
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