<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25304

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIYICAHTDASSQDGFSHIYWRIYTEEAGIANNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLKPLYVRGSDADSNKIVVGTTTLKVSALGSVSSVDLVKGLSSDNQSQHGTQPAGQPRPHQSQPSSRRQDGYSSSAAIYASFISAVTGSIGLQLIRHHAALPLGSRTLFTAVEKSGYESPHINNDSILSTSCLTTLNIQLTMGGTITVSAQTISQTGITRLCGPREDIAELIDVQPGIDLWLCPNGTIAKLVTANVDSPTAPSLGYPPPGNLSAKRVQWKLDVVQWLRNFGLHVYSIDEEPWVEVEVWEPFFARLAGEAWRQSDDGQSALPLKRMLWPARFCFKRASSSNISFGAQNSLLDEPLDFAERWSTMADSLKLDHIPHTAQNTPTTQDLQPKDQGMPSPPKVEPLESIESLSRIAQYPDLQSTNLVYPTPPDGAAAVGLNNPNPSEAFVDDSDFGLPHATQRSSRNEPGSDISPVQNSGVGVGTGRYDESDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDDMEGDSRVEDVDEVLEVSHPQSELEAEAMVDAEPSRNQPQAIPTHVETHEAHASPVHHDAPQLPKGPMASEEPARSSTDRAGQTISPPLSPIEVKKILFPGPEADNHRQPTDNRGQGHYHPVAFEKKLGDWDQKYGAAGKFWFSSGGSLDTSNQTSAIPTIGIPHRGRSSANAPGSKERSKTSLSLVQSENGQRSASVSSDSSEDSIEIVSEHVPTPAAMPSMPSLKRKRVPSESDIMSVASQEKSLPGAEASPAYAAENSTFLGNFLANFSDWTLAGYFSASPPQQLPVLPRREGQLEIAQLLVDQITQSSLKHPLDGEIGLFDLESESLPLQALDDTTFLGESSKLDFKRYTSLQDEFVANQPQQQPPQHPPPPKDTPRSFISKLSAPHIRVRRGKEYLEALPPAISFWETFGLEPAHGPKNISAYCIHPQAASKAADMFLRRFGLLYQSCGLGIHTRGDDSVAFEEGLKPWKSETSSYESMMQVLKRTCEQLGSELSQSPATADNHVVYIINPFTHAAALADICSAFWHLSQQLIAGSERRQTRIASELVLQIIPLEFITSSETMVIPPQMDYLNLALEVYSRCRSNDVDMSPLLCAPPMLLADALPRAIGFRLAPERSSPLQDGRSLHIAYSRSLDQRWISVAWSDLPGSIQRTMSYCLRYRQLSGARPVSEVRNEIWATTKHIMDKFQARWKVQLATTEPMETDEVEAWATLADQHNKVKPGSLELTILAVNTVPDLILEPPVPPISMAMLNILSSSTPVSTPNPSASVASPEQSGNAPTPTSAGPATYNAPTPTDVSLETDSEAVLTDICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRKGATDGDGVFAFTVNLIYSPRPPPSHDSVLKDTLSMYRDLGSLARAKGICSVQNNTLPWHVATALRAQELLSYVF
Length1488
PositionKinase
OrganismPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium> Penicillium chrysogenum species complex.
Aromaticity0.07
Grand average of hydropathy-0.394
Instability index59.04
Isoelectric point5.15
Molecular weight162547.96
Publications
PubMed=18820685

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25304
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.02|     106|     136|     262|     397|       1
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  244-  366 (163.90/129.46)	SAQTISQTGITRLCGPreDIAE.LIDVQPGIDLWLCPNgtiaklvTANvDSPTAPSL.....GYP.PPGNLSAKRVQWKLDVVQW..LRNFGLhVYSIDEEPWVEVEVWEPffarLAGEAWrqSDDGQSALP
  382-  498 (163.12/76.85)	SSSNISFGAQNSLLDEplDFAErWSTMADSLKLDHIPH.......TAQ.NTPTTQDLqpkdqGMPsPPKVEPLESIESLSRIAQYpdLQSTNL.VYPTPPDGAAAVGLNNP....NPSEAF..VDDSDFGLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     573.92|     138|     329|     552|     695|       2
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  552-  692 (223.18/95.47)	..............................................DADFSFFddpdfdDMEGD....S.RVEDVDEVLEVSHP..............Q..SEL.E........AEAMVDAEPSRNQPQAI..P.THVETHEAHASPVHHDAP...Q............LPKGPMA...S..E....EPARS...STDRAGQTISPPLSPIEVKKIL..FPGPEA.......DNHRQPTDNRGQGHYHPVAF.EKKL
  693-  811 (97.50/34.48)	GDW.................................................................................dqkygaagkfwfssG..GSL.D........TS.........NQTSAI..P.TIGIPHRGRSSA...NAPgskE............RSKTSLSlvqS..E....NGQRSasvSSDSSEDS.......IEIVSEH..VPTPAAmpsmpslKRKRVPSE....SDIMSVASqEKSL
  836- 1035 (149.36/56.28)	SDWtlagyfsasppqqlpvlprregqleiaqllvdqitqsslkhplDGEIGLF......DLESE....SlPLQALDDTTFLGE...............S..SKL..dfkrytslQDEFVANQPQQQPPQHP..P.PPKDTPRSFISKL..SAP...HirvrrgkeyleaLP..PAI...SfwEtfglEPAHG...PKNISAYCIHPQAASKAADMFLrrF.GLLY.......QSCGLGIHTRGD...DSVAF.EEGL
 1036- 1139 (103.88/37.17)	KPW.............................................................ksetS.SYESMMQVLKRTCE..............QlgSELsQ........SPATAD.....NHVVYIinPfTHAAALADICSAFWHLSQ...Q............LIAG..S...E..R....RQTRI...ASELVLQII..PLEFITSSETM..VIPPQM.......D........................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.91|      28|     331|     155|     183|       3
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  155-  183 (44.44/27.90)	HQSQPSSRRQDGySSSAAIYASFISAVTG
  499-  526 (50.47/27.23)	HATQRSSRNEPG.SDISPVQNSGVGVGTG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.63|      29|      29|    1220|    1248|       4
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 1220- 1248 (52.64/32.01)	QRTM.SYCLRYR.QLSGARPVSEVRNEIWAT
 1250- 1280 (43.98/25.56)	KHIMdKFQARWKvQLATTEPMETDEVEAWAT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25304 with Med13 domain of Kingdom Fungi
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