Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MANDRLRALEEVENQIATILQCAGNIVLELSKDKHNASFLDRQLSQFTGSVSRVETELSSQIKYLTQVATGQPHEGSTYSARKDCQMALNRAEYARVKLGELGRTCEVMLDPQP |
Length | 114 |
Position | Head |
Organism | Salmo salar (Atlantic salmon) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.465 |
Instability index | 32.97 |
Isoelectric point | 5.67 |
Molecular weight | 12713.23 |
Publications | PubMed=20433749 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP25297 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) FLDRQLSQF 2) SQIKYLTQVA 3) STYSARKD 4) YARVKL | 39 60 77 94 | 47 69 84 99 |
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