<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25291

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTVSSKEKHPSEEANDPIITSRSIESGPKMSNTISWSKNGFIAYAAPELNPKHNLNLTYLENVDGKSWQLAKHQGINVRPSAESNQTPELRLVSWSNLSTDLAVADIHGNFYVLLAGVGLLENKDANGSTSKNNGSSVPSTTSSPSYELTSYNHMEMIYRDIIDPQPTGRMISMSQIVSFKWLNIFKPQIINKPAVLTKVDNNSSSSPPFAYTYGVGQHHPHGTCHPISTKQACIALRQNGECILYFQGEHKVEYHKISIKLQFSSNAVIITKSSIGFKNDKDVIISAFDAVSNSIKTFLISIDWGFLVESAQKQKVDPHYHTPKEAQKVPSLILKTLHEMKPIAANICESNKESEIGDDIMDIDNEDNPKPKDIRLGDISSIDIISPSFDADSKLDILISYAYENEASEITTTIYRYILADSQDLVSETFADLGMRKNVSASLSDEIKDYSLVLQDKLTRPGHIQRIETAVADSFIVLIYTRGEIDVIDRHNLQIVNNRSEIELKNTKDGDTPSTVSTMFDVGFNFPIIPVTDRSPIVIAVSPNLTSIAYTKINNKDQQLNLQVLEKNTNHGISPKELFVTSVGFAFRHSYACYTNSSADDLLALIQSEIKRVSGLLHKSVSDKKHNIETILNKFIESIICESHKAINFQLDAFGKESVDKLLSNPPLQKLLSLQLVLGELQNHDHIISDIAWIVLNLRSTSFGIMFSLSSIYRQISKKKPIDDSLQDSIARGECIMSLIGNVKWLIDLMVYFNQELLQLSYSKDDPSQSKLTMSNSTVLPVLISKVPRLFLIYALSSIGKTHEILKKLNEDLSESNKVFTPMKEALNRYFTICNQSPLNLGLFENFLRECDAFIIKEIGQKVEGKDKGYGLKIEQKLVCQGEITEEILPIAKALIQRHSAYVNRDMKVSELYFYDVDWIDIGIYKLNSNYPEAKFPSDQYPVIHKYPNTLKQVVPRLRFSDKECIDALRKIVISVDFDEGSKTTNLSKLRKCTRCRSFSLVNDPLVFDSPGNIGLWTMVFQRTCICGNAWVNCGK
Length1037
PositionTail
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Debaryomyces.
Aromaticity0.08
Grand average of hydropathy-0.247
Instability index45.78
Isoelectric point6.26
Molecular weight116418.53
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25291
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.11|      40|      55|     655|     696|       2
---------------------------------------------------------------------------
  655-  696 (60.81/47.29)	FGKESVDKLLS.NPPLQKLLSLQLVLGELQNhdHIISDIAWIV
  708-  748 (63.30/41.95)	FSLSSIYRQISkKKPIDDSLQDSIARGECIM..SLIGNVKWLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      17|      71|     123|     139|       9
---------------------------------------------------------------------------
  123-  139 (30.66/17.17)	NKDANGSTSKNNGSSVP
  192-  208 (30.08/16.71)	NKPAVLTKVDNNSSSSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25291 with Med16 domain of Kingdom Fungi
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