<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25290

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMGDMVHLEIDPDLYGDGYKDPFIQDEDKLSMAELIPRILIERSSFLNLTEDSLEQEIACTDNASTEDLKTNEEEIEDKDMDNKETLLHSDSTDDLIDTKNTFENFQKQKFELSKYINSALNETSLSLDFVSLLLSTVKPNIGKSTMSPHLSKSVPIGSLNSDRLSNNTDTSKYKNSAVIGQGWKLESLNKITNSFKNASLRLNEQVLKEKRYWDMINLVLGNHEILYKTRDPANGSRAIGVRYGYGDSGSSYHDRGLAILRKDNQTGEISFNPVSSTNKITNKVYKYIRVKILSKIDDDYMLTGQSIFENNFINTSKYGIINDIEKARFFLFEEDLFYQLTREAKYLINYNVSIIANKIIIEINNEIIEIESIIYDENNEDELSNYYQNINQLSSINNKKAQSILTLLKLMLCCFYKYNLKLKQKIPTAITKWKQSNSHPLILRPLLGHIRHEINVQNMLNILDSHSNEFKEKVKLTIDYEKYVNLKKSQDNIVNPFIKSIERPLTSFEVTVNNLKDGQVLKIYIDISSTEIFCTLIVNLNIIKFESSEKISDNQQGANVLSINFNDLSDLEECLNWTILNFINE
Length585
PositionHead
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Debaryomyces.
Aromaticity0.09
Grand average of hydropathy-0.447
Instability index43.62
Isoelectric point5.13
Molecular weight67307.37
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25290
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.45|      25|      56|     432|     459|       1
---------------------------------------------------------------------------
  432-  459 (42.44/36.04)	KWKQSN.SHPL...ILRPLLGhirHEINVQNM
  487-  515 (35.00/21.20)	KKSQDNiVNPFiksIERPLTS...FEVTVNNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.25|      10|      15|      77|      86|       4
---------------------------------------------------------------------------
   77-   86 (17.68/12.10)	DKDMDNKETL
   93-  102 (17.57/11.98)	DDLIDTKNTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.00|      27|      38|     516|     543|       5
---------------------------------------------------------------------------
  516-  543 (41.22/31.03)	KDGQVLKI.YIDISSTEIfCTLIVNLNII
  556-  583 (43.79/27.70)	QGANVLSInFNDLSDLEE.CLNWTILNFI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25290 with Med17 domain of Kingdom Fungi
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