<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25278

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEDWQSSKFRQNVISKIHDLLPPHAQDQTKNASVMENHIFRKSRSKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQQQQQQQPPPPNAEMGQQNMMQDPLNALQNLATQGNRNPQMMPMSGGAPVPGGPGTASNLLQSLNQQRPGQQMQPMPNIRGQMPMGAGAGGPQQMMQVQQMGGGGNATGVMNVMGAGGAQGQGQIVGNAGQQMGGMPNQMVGPGPNSGPAGGTGGPNAPPGAGAGPVPNQMQSGGPMNVNSMQQMPPMQQIQQNQMAMGMSPMMRMGQGNGMGGPQGMGQGMQGMPPNMQQPQHNVGVGGPAGQQQQVVPPNAVQQAGMNPMGGMGVNMPPNIQQKPNMAMGQGGQMFPGNRGGVVGGQQGPGQPFMRSSPSPADAQQLQQQQQAQLQQMQQQQQQQQQQQQQQQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNPQRNIRQQSPSNASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALERMDLISISGQQFGKSSNPLLEVINTTLQSPIANHTLHRTFRPTLELLFGTDIVAPVPAKKPRIEEKSSPFEQDVPHVLQGEIARLDTKFKVKLDTTSQINNKSIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLTEQEYSATPFLQTVQQALIARISMLPKNYSLSHLLDTWEMAVRQACSPQTKPKVCEFTALFGV
Length761
PositionTail
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.732
Instability index70.21
Isoelectric point9.35
Molecular weight82828.66
Publications
PubMed=15632085
PubMed=17994087
PubMed=23185243

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25278
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     750.49|     150|     337|      22|     171|       1
---------------------------------------------------------------------------
   22-  171 (284.16/57.14)	LPPHAQDQTKNASVMENHIFRKSRSKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQQQQQ........QQPPPPNAEMGQQNMMQDPLNALQNLATQGNRNPQM..MP..MSGGAPV.P.GGP.GTASNLLQSLNQQRPGQQMQPM........PNIRGQMPMGAGAGGP......QQ
  172-  261 (96.15/13.88)	........................................................MMQVQ........QMGGGGNAT.GVMNVMGAG.GAQGQGQIVGNAGQQMggMPnqMVG..PG.PnSGP.AGGTG...GPNAP.PGAGAGPV........PN...QMQ....SGGPmnvnsmQQ
  262-  363 (162.93/29.24)	MPP......................M...........................QQIQQNQM........AMGMSPMMRMGQGNGMGGPQGMGQGM..QG.MPPNM..QQ..PQHNVGV...GGPaGQQQQVVPPNAVQQAG..MNPMggmgvnmpPNIQQKPNMAMGQGG........Q
  365-  495 (207.25/39.44)	FPGNRGGVVGGQQGPGQPFMRSSPSPADAQQLQQQQQAQLQQMQQQQQQQQQQQQQQQQQQlvgnqtptQQPPTP..QMPTPQMIPSP.....ALVPQS..SPQM..MM..QNPQRNIrQ.QSP.SNA.....SIN..TPGQ...............VTGNSPF.....NP......QE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.77|      17|      22|     567|     583|       2
---------------------------------------------------------------------------
  567-  583 (27.98/17.87)	ISGQQFGKSSNPLLEVI
  591-  607 (28.80/18.61)	IANHTLHRTFRPTLELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.85|      11|      86|     545|     563|       4
---------------------------------------------------------------------------
  528-  538 (18.51/12.59)	EKMTKMSKLLE
  550-  560 (18.33/ 9.89)	ETLLKCEKALE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25278 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNVISKIHDLLPPHAQDQTKNASVMENHIFRKSRS
2) YKDMSRKSQQQQQQQQQQQQQQQQPPPPNAEMGQQNMMQDPLNALQNLATQGNRNPQMMPMSGGAPVPGGPGTASNLLQSLNQQRPGQQMQPMPNIRGQMPMGAGAGGPQQMMQVQQMGGGGNATGVMNVMGAGGAQGQGQIVGNAGQQMGGMPNQMVGPGPNSGPAGGTGGPNAPPGAGAGPVPNQMQSGGPMNVNSMQQMPPMQQIQQNQMAMGMSPMMRMGQGNGMGGPQGMGQGMQGMPPNMQQPQHNVGVGGPAGQQQQVVPPNAVQQAGMNPMGGMGVNMPPNIQQKPNMAMGQGGQMFPGNRGGVVGGQQGPGQPFMRSSPSPADAQQLQQQQQAQLQQMQQQQQQQQQQQQQQQQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNPQRNIRQQSPSNASINTPGQVTGNSPFNPQEEAL
12
61
46
498










Molecular Recognition Features






MoRF SequenceStartStop




1) LGLVAKLFMHYK
51
62