<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25274

Description GD17845
SequenceMHSPHILETLSGSAIFASKIDDLANTDSDTVTSDPSHDSNKSQEIKECTSLDSNSNSVQSLPLANNRENLIPKNVNDITTQLMHLIHSLNSPLSIIEIERVYQEKIIPCTCIVIEEVEGTLGESNNCTLDDQSKNAKISLNSKDNLFCHNQDNFPTSQRSINGEVIDTQPKLVKSIFDLDFDDNDDPLNLIMDEIQKPIARAEELKNNKSDTKNIHFGASAQNVSFNINFSDDAQQDNSNQEREKSETQNAIPAFTVHEDPDCLARQRFYIQTNKVTSFHINALHNYYIPNINGNWDSVESFTSFQPKHTIMDTMESYTVTNGADVVPKYGLLTSDRIRKDLSSLKSIKPYRVKKFTSLFSPFLGVAKCLPTCRRARRRLKNFVTLSTANDNTAKNFESLENMKASFKNCNPLNVKIDGTTSAIYSHNENHVPMQVNTNVEQLPPSQSFSGNAISYNLLKLADDKVRDDEISDKSSNHGCQENSPYSSSSSSGYSDSKEDQHNIIKNQQNKSIQLNSRNSDMNRRKRRIYLEDDSKKKKHYRKRIKAAVNGTCSNLHRNLNSSDSENGMENDYKNEYGNSNNEEYAIVQRPAGDGENCRNHIVLTIKKTPSKINSPANSMNAFSPSSTSDAANLKKSILDFCLEDTNISQSITEIPQKKKEDLSKSNRIVHQSRCSAYRRIFRKSDKSQTKFIDLELKHLFHLKSNPPCILANSKLHNKLFFPHELSMDNTSGIRERIINYSSSSSSSYDDDSEVENTSFVKKANVKKCSAYNNHNLKTETETCAATAISEFKFESDEDSMLTSLGDSDIDIQDEIHATNDSVDYCNDFQNNKMLESFNSIFVDSLRTNTKNESGNMESSPHITSLESLKPENVDAISRYCNNNNLGVNLSNELSNTSAKSIKSLDSTEKLPSLGNEHCTGIKTSSDLASTSIADKKLTRIQQFKEWHQVLQLKSYNNEPLIVLPYVLLE
Length970
PositionUnknown
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.770
Instability index44.49
Isoelectric point5.91
Molecular weight109174.73
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IEA:EnsemblMetazoa
pericentric heterochromatin	GO:0005721	IEA:EnsemblMetazoa
polytene chromosome chromocenter	GO:0005701	IEA:EnsemblMetazoa

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     868.30|     242|     254|     266|     511|       1
---------------------------------------------------------------------------
  266-  472 (308.41/168.96)	............................................................R..QRFYIQTNKVTSFH....INALHNYYI...PNINGNWDSVESFTSFQPKHTIM..DTMESYTVTN.GADVVPKYGLLTSDRIRKDLSSLKSIKPYRVK...KFTS.LFSPFLGVAKCLPTCRRARRRL.KNFVTLSTANDNTAKNFESL.ENMKASFKNCNPLNVKIDGTTSA...IYSHN........ENHVPMQVNT.NVEQLPPSQSfSGNAISYNlLKLADDKVRDDEIS
  473-  727 (320.51/174.17)	DKSSnhGCQEN.SPYSSSSSSGYSDSKE.DQHNIIKNQQNK.....siqlnsrnsdmnrrK..RRIYLEDDSKKKKHyrkrIKAAVNGTC...SNLHRNLNSSDS.......ENGMenDYKNEYGNSN.NEE....YAIV..QRPAGDGENCRNHIVLTIK...KTPSkINSPANSMNAFSPSSTSDAANLkKSILDFCLEDTNISQSITEIpQKKKEDLSKSN..RIVHQSRCSAyrrIFRKS........DKSQTKFIDL.ELKHLFHLKS.NPPCILAN.SKLHNKLFFPHELS
  729-  961 (239.38/123.84)	DNTS..GIRERiINYSSSSSSSYDDDSEvENTSFVKKANVKkcsaynnhnlktetetcaaTaiSEFKFESDEDS..M....LTSLGDSDIdiqDEIHATNDSVDYCNDFQNNK.ML..ESFNSIFVDSlRTNTKNESGNMESS...PHITSLESLKPENVDaisRYCN...NNNLGVNLSNELSNTSAKSI.KSL.......DSTEK.LPSL.GN.....EHCTGIKTSSDLASTS...IADKKltriqqfkEWHQVLQLKSyNNEPL.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.67|      31|      87|     115|     153|       2
---------------------------------------------------------------------------
   44-   77 (47.93/23.71)	EIKECTSLDSNSNSVQSLplaNNRENLIPKNVND
  123-  153 (55.74/27.76)	ESNNCTLDDQSKNAKISL...NSKDNLFCHNQDN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25274 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TCSNLHRNLNSSDSENGMENDYKNEYGNSNNEEYAIVQRPA
2) VRDDEISDKSSNHGCQENSPYSSSSSSGYSDSKEDQHNIIKNQQNKSIQLNSRNSDMNRRKRRIYLEDDSKKKKHYRKRIKAA
552
466
592
548










Molecular Recognition Features






MoRF SequenceStartStop




1) AYRRIFRK
2) GIRERIINYSS
3) HYRKRIKA
4) RIYLE
677
733
540
528
684
743
547
532