<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25261

Description GD14832
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNASKVSAFFSGVLAKKEELMTLPDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQTNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQINPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAVAQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGAGPQQAGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQYQPPPY
Length640
PositionKinase
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-1.009
Instability index61.14
Isoelectric point10.12
Molecular weight70625.84
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     512.12|      63|      63|     321|     383|       1
---------------------------------------------------------------------------
  288-  341 (89.41/12.99)	MQQQQ....QQQ.....NAQQQQM..NPNQQQQ...QQF..........MRggnmrpGM.APN..Q..MNQM...NMGGQGMPQNP
  342-  400 (109.94/17.78)	MMQQQI...PQNMVGMVNPNANQMMQSGGAQGG...NGVG...VGVGVGVG........gAGN..N..PN.M...GMGG..MPQQG
  401-  466 (99.16/15.27)	MMQQQPqqqPQQQVQFQNFQ.NQYQQQQQQQQGmqqQGGG...AGVGVGVG.......M.APNqqQ..QQQA...NMMGN...FNP
  467-  515 (73.84/ 9.36)	QMQQAN...RNNPDFMAAAAVAQQQQQQQQQQ..............RVVPG......GMmAGN..R...NQY.........MNQAP
  522-  566 (71.61/ 8.84)	MMGPG....PGGVVGQVPPYARQ..QSAG..GG...K.............P......GV.L.N..T..QQQF...Q..QQQQQQQQ
  567-  629 (68.18/ 8.04)	LRHQQM...MQ.MQGM..........GGGAGGG...MGAGpqqAGGAVGGG...gggGM.VPQ..QqsMNQQqtpNLVAQLQRQNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.88|      25|      27|     227|     251|       2
---------------------------------------------------------------------------
  199-  223 (29.63/ 6.54)	..QEYYQQTNRieRPPLNANSKQALSQ
  227-  251 (51.77/18.96)	QRQPFQQQAQQ..GPGGGFNPMQQQPQ
  254-  270 (29.48/ 6.46)	QQQPGPQQ.QI..NP....NQMRQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     127.12|      41|      42|      73|     113|       3
---------------------------------------------------------------------------
   19-   43 (24.99/ 9.15)	......................PDIYPQdaKQ........R...EDELTPTNVKHGFT
   65-  108 (70.69/37.87)	VSAFFsgvLAKKEELMTL....PDTGRK..KQ........QINCKDNFWPVSPRRKCT
  109-  154 (31.45/13.21)	VDAWF.kdLAGNKPLLSLakraPSFNKK..EEifitlcenQVNMQRATW.........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25261 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAH
2) YYQQTNRIERPPLNANSKQALSQMLRQRQPFQQQAQQGPGGGFNPMQQQPQPSQQQPGPQQQINPNQMRQQQMNPQQNPQSVAAFNAMQQQQQQQNAQQQQMNPNQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMPQNPMMQQQIPQNMVGMVNPNANQMMQSGGAQGGNGVGVGVGVGVGGAGNNPNMGMGGMPQQGMMQQQPQQQPQQQVQFQNFQNQYQQQQQQQQGMQQQGGGAGVGVGVGMAPNQQQQQQANMMGNFNPQMQQANRNNPDFMAAAAVAQQQQQQQQQQRVVPGGMMAGNRNQYMNQAPNVTMSTMMGPGPGGVVGQVPPYARQQSAGGGKPGVLNTQQQFQQQQQQQQQLRHQQMMQMQGMGGGAGGGMGAGPQQAGGAVGGGGGGGMVPQQQSMNQQQTPNLVAQLQRQNMMGQQQYQPPPY
1
201
56
640










Molecular Recognition Features






MoRF SequenceStartStop




1) YQPPPY
635
640