<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25259

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISLGKTPTIIHTGPFYSMKEPPAKAELTGDKDLMTEYGLHHTLTKFKEKKFKESLASFLQNIPGINDLITHPVENSTLRSVIEKPPIGGKELLPLTPVQLAGFRLHPGPLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGMLPGGAGLGGAAGVMGATSLGSLGGGPGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSCGGMLGSVLGTSGGPGGGGGGGGGGGGGGSLLMSQF
Length334
PositionHead
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.716
Instability index59.61
Isoelectric point9.90
Molecular weight35207.89
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:EnsemblMetazoa
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25259
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     126.08|      20|      20|     231|     250|       1
---------------------------------------------------------------------------
  231-  250 (35.16/11.37)	LPG..GAGLGGAAGVMGATSLG
  252-  273 (27.38/ 7.24)	LGGgpGPGLSSLSASMGPGVVG
  290-  308 (33.00/10.23)	MPM..QQQQMSCGGMLGSV.LG
  312-  330 (30.53/ 8.92)	GPG..GGGGGGGGGGGGGSLL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.61|      33|      33|      40|      72|       2
---------------------------------------------------------------------------
   16-   36 (21.60/ 6.75)	...........PHGGGRSPvVAR..QDSSG..TLKT
   40-   72 (58.77/29.80)	LGKTPTIIHTGPFYSMKEP.PAK..AELTGDKDLMT
   76-  107 (45.24/21.41)	LHHTLTKFKEKKF...KES.LASflQNIPGINDLIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.74|      12|      20|     193|     204|       3
---------------------------------------------------------------------------
  163-  173 (20.76/12.12)	KNKHKKHK.HKD
  193-  204 (22.65/13.82)	EKKHKKQKRHED
  214-  225 (19.33/10.82)	EKKRKKKNQSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      17|      22|     123|     143|       4
---------------------------------------------------------------------------
  123-  143 (20.62/23.40)	PIGgkELLPLTPVQLAgfRLH
  146-  162 (31.76/18.56)	PLP..EQYRTTYVTPA..RKH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25259 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMSNYGNMMDSPKSSPHGGGRSPVVARQDSSGTLKTTISL
2) PLPEQYRTTYVTPARKHKNKHKKHKHKDGVTTGQESTLLDSAGLETYEKKHKKQKRHEDDKERKKRKKEKKRKKKNQSPEPGVGMLPGGAGLGGAAGVMGATSLGSLGGGPGPGLSSLSASMGPGVVGNMNSFSSSMQMQQQQQMPMQQQQMSCGGMLGSVLGTSGGPGGGGGGGGGGGGGGSL
1
146
40
329










Molecular Recognition Features






MoRF SequenceStartStop




1) GGGSLLMSQF
325
334