<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25258

Description GD12888
SequenceMDYDFKMKTQIERTKVEDLFNYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQQQQQQQQQQQQQQQQQQQQQQQQMNAEPNAKRVRLSGAGNQQDFHHQQQQQQQQQQQQQQQQQMMFNQQQNFQQRFN
Length451
PositionKinase
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.09
Grand average of hydropathy-0.891
Instability index55.51
Isoelectric point8.77
Molecular weight53296.85
Publications
PubMed=17994087
PubMed=22936249

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
G1/S transition of mitotic cell cycle	GO:0000082	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of autophagy	GO:0010508	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa
snRNA 3'-end processing	GO:0034472	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.85|      15|      16|     366|     380|       1
---------------------------------------------------------------------------
  366-  380 (28.74/ 9.26)	DKSDNKRQQQQQQQQ
  383-  397 (28.01/ 8.86)	QQQQQQQQQQQQQQQ
  416-  428 (26.10/ 7.84)	Q..DFHHQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.00|      27|      47|     158|     184|       2
---------------------------------------------------------------------------
  125-  148 (15.84/ 6.04)	........RGMVKsllyqILD.G..IHYLHsNW.VL
  158-  184 (48.53/30.95)	LVMGDGNERGRVK.....IADMG..FARLF.NA.PL
  204-  233 (34.63/20.35)	LLLGARHYTKAID.....IWAIGciFAELL.TSePI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.71|      16|      27|     239|     256|       3
---------------------------------------------------------------------------
  239-  256 (23.28/25.52)	EDIKtSNPYHHdQLDRIF
  268-  283 (31.43/21.51)	EDIK.KMPEHH.TLTKDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25258 with CDK8 domain of Kingdom Metazoa
Unable to open file!