<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25255

Description GD13562
SequenceMAPTPLPLEQMPGVGGGGGGYLPAAQEGGPRINTMSMSVLIDFIIQRTYHELTVLAELLPRKTDMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKRQTLLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITEEMQDCLNGDRSKLPALLSELRFWITHRRCDKTLQHLPATATETLPFLVQPDQEILQPGRHKIYVKLHRHPNIVLVVQLKEKTTMPNEMEYTFHLGFVAFQKDELDVIDDSAMQLVSIVAQPHSDIPKCYTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSNGDLLAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKTTFANQQQQQQGAPAGSGENKPTGTSGLPKIDSHVWDDLMRRVLSISIRSQTNKNSQVRIWVVEFVFYSTPLQSCHPKEQGSRRTVYLTYEQANYDFSKTVEDLLNDWSKIVYLYTLVYDFAEQLQNKRLSLCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNGHSMMRDQLAQHLNQHHSITQIAQILHETYNPLSSIAKLPVLPFLGIPRPQVPVLSFCVLAQSPCLIRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVVEEFTPIQGLKAFLSKYVDESAVYRGRASHEDDNPLSPMGMEDNFGGPSSVAGVSAGGSSPFLGTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGAGGGSGPQGHGNFNLTSPPAPHMPHPSPSGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNNWPGSPSMPRPSPRPGQSPEHKSTGGGAGGAGGADRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPYPNKDINVPDMSPLERFLGCVYMRRQLHRNIQSEETLTALNSTEPGVVLFKVDGLQCQVVLNQMHMQTLHLKVSQLPPMPDKHPPPFQLSQDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLDLKPELGGDQLKWTVQICLRMPPSAVPIVPSGNACVVMGRMKILFFLLITRIPYVAVIGQGKDWKDSPSLVLPIVYDIQTNVTQLAERTGQVISPTMTAASTLLRRFADFNAQQNQCTLFPAITDLLTNLQLAAEMPQPPPNQSIGPPVGVGVGVGVGVGVGSSPNPMMPMQQLPQQVGPQGPVGPGGYPQMGPNPGGPQ
Length1559
PositionTail
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index53.20
Isoelectric point8.26
Molecular weight172786.63
Publications
PubMed=17994087
PubMed=22936249

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25255
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     252.08|      39|      39|    1038|    1076|       1
---------------------------------------------------------------------------
 1003- 1037 (32.52/ 8.31)	.........RGRA........SHEDdnplSPMGME.DNFGG.PSSVA..GVSAGGS
 1038- 1076 (80.47/30.71)	SPFLGT.GMRGPQ........SPRD....SGLRFP.APHTP.PSSSN..PHTPASP
 1077- 1120 (46.72/14.94)	HPSAGAgGGSGPQghgnfnltSP...........P.APHMPhPSPSGlmPSSPLNP
 1143- 1172 (47.90/15.50)	SPF..T.AM............SPAN....NN..WPgSPSMPrPS.....PRPGQSP
 1533- 1558 (44.47/13.90)	LP.....QQVGPQ........GPVG....PG...G.YPQMG.PNPGG..P......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.38|      28|     105|     802|     829|       2
---------------------------------------------------------------------------
  802-  829 (47.84/30.88)	NDWSKIVYLYTLVYDFAEQLQNKRLSLC
  908-  935 (46.41/29.71)	NPLSSIAKLPVLPFLGIPRPQVPVLSFC
  939-  963 (34.12/19.68)	QSPCLIRLTYQAVYCLELRFRANRL...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      10|     365|    1121|    1132|       4
---------------------------------------------------------------------------
 1121- 1132 (18.73/13.61)	QPSPHmvHSPGP
 1497- 1506 (22.41/ 9.70)	QPPPN..QSIGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.64|      27|      39|     446|     472|       5
---------------------------------------------------------------------------
  417-  436 (26.08/ 9.40)	....P.AILTVPV...LSPCLRAEQIHI
  446-  472 (50.18/24.28)	RCHVP.KHLDCPITEEMQDCLNGDRSKL
  487-  514 (40.38/18.23)	RCDKTlQHLPATATETLPFLVQPDQEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.04|      76|     111|    1218|    1298|       6
---------------------------------------------------------------------------
 1218- 1298 (114.95/106.68)	RPSPYPN..KDINVPDmSPLERFLGcvYMRRQLHRNIQSEE...TLTALNSTEPGVVLFKVDGLQCqVVLNQMHMqTLHLKVSQLP
 1332- 1412 (122.09/89.32)	RPNSLHSicRLLNLPA.QVLKDFVQ..IMRLDLKPELGGDQlkwTVQICLRMPPSAVPIVPSGNAC.VVMGRMKI.LFFLLITRIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.25|      38|      73|     118|     190|       7
---------------------------------------------------------------------------
  118-  156 (60.05/71.26)	TADMLARMsRETLVRARLPNFHIPA..AVEVLTTGTYNRLP
  191-  230 (61.20/19.87)	TGKLLPQM.REFRIRNGRVTFEVKHefSVSLTVMGDNPTVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      39|     294|      70|     108|       9
---------------------------------------------------------------------------
   70-  108 (67.23/52.79)	EIYNYAARTRHL.FTRLNALVKWGNSVSKV.DKSSQIMSFL
  366-  406 (55.51/42.18)	EVADRAVRSEHLsMERLIVHTVYIRSVSRLsDLKLEFQAFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.20|      16|    1162|      15|      31|      13
---------------------------------------------------------------------------
   15-   31 (29.01/21.05)	GGGGGGyLPAAQEGGPR
 1178- 1193 (32.20/17.97)	GGGAGG.AGGADRGGSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25255 with Med14 domain of Kingdom Metazoa
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