<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25246

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEDWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGANATPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIDPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKTIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAICELSTLLGV
Length749
PositionTail
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.648
Instability index60.80
Isoelectric point9.38
Molecular weight80569.24
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25246
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     244.03|      29|      29|     142|     170|       1
---------------------------------------------------------------------------
  125-  160 (49.06/12.36)	VPGG.PGTASNllqslnqQRPGQQ.....QMQ..PMP....NIRGQMP
  161-  188 (37.00/ 7.09)	MGAG.GAGAQQ.............mmqvqQMQ..QGG....NAPGVMN
  231-  264 (40.72/ 8.72)	GGAG.GANATP.....gaGGPGPN.....QMQggPMN...vNAMQQMP
  284-  315 (43.02/ 9.72)	MGQGnGMGGPQ.......GMPG.Q.....GMQ..GMPqgphNVVGG.P
  367-  397 (37.47/ 7.29)	GNRG.GVGVGG.......QQPGQP.....FMRssPSP....ADAQQLQ
  433-  462 (36.76/ 6.99)	MIPS.PALVPQ.......SSPQMM.....QMQ.nSQR....NIRQQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.83|      38|     130|     189|     229|       2
---------------------------------------------------------------------------
  189-  229 (70.61/25.62)	VMGAGGGQNQGQIVG.NPGQqmGVGVGMPNQMvGPGPNS..GPA
  321-  361 (60.22/15.44)	VGGAGLPPNAVQQGGmNPMG..GMGVNMPPNL.QQKPNMpmGQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.99|      15|     332|      69|      87|       3
---------------------------------------------------------------------------
   69-   83 (30.51/ 6.39)	QQQQQQQ...QQQGGPPP
  107-  124 (21.47/ 7.90)	QGNRNPQmmpMGAGGGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.12|      27|      41|     515|     541|       4
---------------------------------------------------------------------------
  515-  536 (34.26/22.16)	..........EKM..........TK.MSK.LLEILCNP..TQRVPL
  537-  578 (25.01/14.02)	ETLLKcekalEKMdlisysgqqfGK.SSNpLLEVI.NT..TLQSPV
  581-  604 (23.85/12.99)	HTLYR....................tFRP.TLELLFGTdiTAPVP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.98|      32|      77|     611|     660|       5
---------------------------------------------------------------------------
  611-  642 (53.30/66.06)	EEKSTSFEQEVPHVLQGEIARLDTKFKVK..LDT
  689-  722 (48.68/24.11)	EYSATPFLQTVQQALIARISKLPKNYSLShlLDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.61|      11|     135|     266|     277|       6
---------------------------------------------------------------------------
  266-  277 (19.28/10.94)	MQQiQQNQLGMG
  405-  415 (22.33/ 8.94)	MQQ.QQQQLVVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      11|      54|     417|     427|       7
---------------------------------------------------------------------------
  417-  427 (22.83/ 8.78)	QTPTQQPPTPQ
  471-  481 (21.09/ 7.53)	QVTGNSPFNPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25246 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNVISKIHDLLPPNAQDQTKNAGVMENHIFR
2) YKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMPNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGANATPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEAL
12
61
42
485










Molecular Recognition Features






MoRF SequenceStartStop




NANANA