<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25245

Description GD22978
SequenceMEVIKPMDFSSFSAFCEHLNKSSQIAASTATTIPPTLNNGKGIYLEKMERQGKMELAAKERESQRLQLIPKKWNRREEYEFLRVLTGYGVDLHLSTSMGSTNGSSLSPDWTKFKQMAHLERKSDETLTDYYKVFVAMCKRQAGLKLTESERGLEGIIEEIEKEHAKLILDRLEVLAKLREVARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLKHGLYRSETFIFNDPNFSFGESEKRFIRELEAQIQRTIKLEAFNAEKAEKLAAAEKAAATEKAAATEKAAAEKAASVKNEVIDLDDELMTNESVIKKESTVTPIKEEIKSEESPEKQDTADILEDKNSDAEESTKIKDKADFNSEITDKEALDESTNLNKDKSSTETFVPEIEDIKPSEEKMEVEEVPVAENGEEKEGAPEKCSDAEDKKLSEEKPSSPVVPDGKVSEMEADEVVSNTEENCSGESESPEKECEDKAEEQKEETEKLEKSSIESEPSEKSETALEPEVAVPKKLTGDQDILDLVAGPSDPDDDEVMKEKEKAVEEECKKQAAELKARFPDLEVIQPATVKQQKLEKPKLEMCMIRWFKDFALERRIAHIVACVESGNWPVDSKYSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTKHLQTSHMQQVASSASAASTSSGVPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLPGMSLSAATGSSAGGVSGLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAPKDWESEIANMEALSGSSGRGRGGNSSALSGMQPPPAHQHASLSRQSSGQFSKPAVPALKTPPPSMGAPMDLSSSLPKMNMTEMLKSASSSGAIDLSEVQDFSMPSKKSSVHAALSSAFPSMGSKSKLDDTLNKLMKKNNCTIEEPVIGKEKKRKKLDEIVLGLSAAKEQKTFPDPSLPSSKKPQIPPSVSVTPANLQSSSNQQTNQKPFTITVTTVPGKSKSGSSNSGSGTGGSSSASGGGAGGSVLSALQNMSMGGLSSKDSLNALLAQTMATDPQTFLKQQQKMMQFLPPAQRKAYENMLAEMEQAMKISSKFSTNSPHDVKVNKWLSDMTSPLGDQLSIDYVGGGGASGSGSGNSRRSNRQQGNSQQSSSAAQLQKQQQQQQQQQQQQHSMPGPQNLTGEEPVPVINKQTGKRLGGNKAPQLKRLMQWLTENPNYEVDPKWLEQMQNPMSAPSPKPPSMESSYGSSAVKSHGGRPSSNSSNTSSSSHTQQHQQSSAAQSQAGGNSGSSKKNSRQQTAQSAALDQAALQFGSLAGLNPSLLANLPGLGAFDPKNPLAAFDPKNPLLSMSFGGMPGMGNIPGLGNLNNMNLFASLAGMGGLGNLAGMDTQSLAALMAAAGPTLGGLSGASGGAGSGKSQAQSQSSATSSSSSASKKKQQQQQQQAQNEAAQLAAAISASTAGSGASGGKNAAASASQLAAGFPFLFPNPSLLYPPMGLGGLNPYSLGSSGLGSAYDQLAQQYNLLNGATSSASNTSSTQSKSHQSQSKSSQSRNTTASANSAASLMNAMASMGGGASTVTTPSTSASGSGRGRQSSSRNQSQTTPTAADMAQLSSLLMPGADPHLLESLSRMSNMDLAQATRLMSSLGMPPLSGTPSSSGGGNTSTSKRSSQAANEANAQAKEQQKWFESLARGALPTDLAALQAFSQGKMPSTSGSNTGTSTSSSKSSKAAAAAAAAQLPQIPGMSSDFPQAFLAEMAAQAMAAAGGSLPLSGPGSLASLAGLTGGSAGGGGGSSASGSTSHSSSKRQREQDAFKQQMDYYTKTLGLGSGISLIPTSSAGGSSASSSTANAAAAAYAAALDAEQQHQQQQKALSKRSRGDIHPTKEELAAAALAAGLPLNLGASMSSIEKSLRGGSSSSSNSTPAPMSAEQDKVTLTPLNASGGGSGSSSSSAAAAGLAANLPSQTTITIAPPISSGASTSSERSERSESRISLTITNAADAAKLPPPYEEADELIIQPILKKPTAANPGSSHSGSVDDLDTAENTSAANLSGSSSSSAAAAAAAAAAAEENRRSSNRLKRPRSGNEQGSGSVEGQPPEKRRELRSTRHTRSSADASTLNLSTGSESGAEERNE
Length2141
PositionKinase
OrganismDrosophila simulans (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.590
Instability index57.59
Isoelectric point5.99
Molecular weight223517.42
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25245
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     895.05|      72|      73|    1847|    1918|       1
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  799-  866 (70.51/30.25)	.....SGS..SGRG.......RG..GNSSALSGMQ........PP........PaHQH..........................................ASLSRQSS.......GQFsK...PAV..PAL......KT...PPPSM.G..A.....P............MDLSS.SLPK.......MNM.T
 1144- 1250 (63.48/26.19)	RRS..NR....QQG......NSQQSSSAAQLQKQQ........QQ........Q.QQQqqqqhsmpgpqnltgeepvpvinkqtgkrlggnkapqlkrlmQWLTENPN.......YEV.D...PKW..LEQ......MQ...NPMSA.P..S.....P..............KPP.SM..........ES.S
 1290- 1367 (70.79/30.41)	GGN..SGS..SKKN......SRQQTAQSAALDQAA........LQfgslaglnP.SLL..........................................ANLPGL.........GAF.D...PKN...PL......AAfdpKN..P.L..L.....S............MSFGG..MPG.......MGNiP
 1417- 1465 (47.49/16.95)	GGA..GSG..KSQA......QSQSSATSSSSSASK........KK........Q.QQQ..........................................QQQAQNE...............................A...AQLAA.A..I.....S............AS....................
 1467- 1515 (39.76/12.49)	AGS..GAS..GG.K......NAAASA.......SQ...............................................................................................L..............AA.G..F.....PflfpnpsllyppMGLGGlNPYS.......LGS.S
 1516- 1584 (60.45/24.44)	GLG..SAY..DQLAqqynllNGATSS.ASNTSSTQ......skSH........Q.SQS..........................................K..SSQSR.......N...T...T.............AS...ANSAA.S..L..................MNAMA.SMGG.......GAS.T
 1593- 1656 (56.84/22.35)	SGS..GRGrqSSSR......NQSQTTPTAA.DMAQlssllmpgAD........P.HLL..........................................ESLSRMSN.......MD...........................LAQ.A..T.....R............L......MSS.......LGM.P
 1667- 1723 (64.79/26.95)	GGN..TST..SKRS......SQAAN......EANA........QA........K.EQQ..........................................KWFESLAR.......GAL.....PT....DL......AA..lQAFSQ.G...........................KMPS.......TSG.S
 1726- 1789 (68.05/28.83)	GTS..TSS..SKSS......KAAAAA.AAA..............Q........L.PQ.............................................IPGMS........SDF.....PQAflAEM......AA...QAMAAaGgsL.....P............LSGPG.SLAS.......L.A.G
 1799- 1844 (55.16/21.38)	GGS..SAS..GSTS......H........S...SS........KR........Q.REQ..........................................DAF..KQQ.......MDY.Y....TK................T.L...G.......................LGS.GISL.......IPT.S
 1847- 1918 (119.31/58.44)	GGS..SAS..SSTA......NAAAAAYAAALDAEQ........QH........Q.QQQ..........................................KALSKRSR.......GDI.H...PTK..EEL......AA...AALAA.G..L.....P............LNLGA.SMSS.......IEK.S
 1921- 1949 (32.05/ 8.04)	GGS..SSS..S.........NSTPAP....MSAEQ........D............................................................................................................kvtltP............LN.................A.S
 1950- 1992 (57.49/22.73)	GGG..SGS..SSS.......SAAAAGLAANLPSQ............................................................................................................TTITI.A..P.....P............ISSGA.STSS........ER.S
 1995- 2053 (47.58/17.00)	SES..RIS..LTIT......NAADAAKLPPPYEEA........DE........L.IIQ..........................................PILKK..................PT............A....A............................NPGS.SHSGsvddldtAEN.T
 2054- 2139 (41.30/13.38)	SAAnlSGS..SSSS......AAAAAAAAAA..AEE........NR........R.SSN..........................................RL..KRPRsgneqgsGSV.EgqpPEK.rRELrstrhtRS...SADAS.T..L.....N............LSTGS.ESGA.......EER..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.96|      15|      15|    1000|    1014|       2
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 1000- 1014 (26.00/10.65)	TVPGKSKSGSSNSGS
 1016- 1030 (25.69/10.40)	TGGSSSASGGGAGGS
 1034- 1048 (22.27/ 7.71)	ALQNMSMGGLSSKDS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.55|      17|      17|     295|     311|       3
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  325-  343 (17.14/ 7.68)	EIKSEES............pEKQDTADiLED
  458-  487 (16.52/ 7.06)	ENCSGESespekecedkaeeQKEETEK.LEK
  489-  504 (23.90/14.46)	SIESEPS.............EKSETA..LEP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.40|      46|      47|     378|     423|       4
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  378-  416 (56.58/34.08)	............................................KDKSSTE..TFVPEIEDIKPSEEKMEVEEVPVAENGEEKEG
  417-  457 (43.44/24.15)	APEK.CSD...................................aEDKKLSEekPSSPVVPDGKVSE..MEADEV.VSNTE.....
  466-  539 (32.49/15.88)	SPEKeCEDkaeeqkeeteklekssiesepseksetalepevavpKKLTGDQ..DILDLVAG..PSDP..DDDEV.....MKEKEK
  540-  575 (38.90/20.72)	AVEE.ECK....................................KQAAELK..ARFPDLEVIQPATVKQQKLEKP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.56|       9|      15|     267|     276|       5
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  267-  276 (12.08/ 9.67)	EKlAAAEKAA
  285-  293 (16.48/ 8.16)	EK.AAAEKAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.10|      27|      27|     904|     930|       6
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  904-  930 (44.63/26.03)	PSMG.SKSKLDDTLNKL.MKKNNCTIEEP
  933-  960 (34.74/18.41)	GKEK.KRKKLDEIVLGLsAAKEQKTFPDP
  972-  996 (26.73/12.24)	PSVSvTPANLQSSSNQQ.TNQKPFTI...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.90|      16|      20|    1377|    1392|       7
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 1377- 1392 (27.56/13.07)	LFASLAGMG.GLGNLAG
 1398- 1414 (24.34/10.52)	LAALMAAAGpTLGGLSG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.38|      14|      15|     663|     676|       8
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  663-  676 (20.23/ 7.02)	SHMQQVASSASAAS
  679-  692 (25.05/10.95)	SGVPQVTQSKPSSS
 1274- 1287 (21.09/ 7.71)	SHTQQHQQSSAAQS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.75|      69|      90|      36|     110|       9
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   36-  110 (105.19/83.65)	TLNNGKGIYLEKMERQGKMELAAKER.........ESQRLQLIpkkWNRREEYEFLRVLTGYGVdLHLSTSMGSTNGSslSPDW
  126-  203 (108.56/68.22)	TLTDYYKVFVAMCKRQAGLKLTESERglegiieeiEKEHAKLI...LDRLEVLAKLREVARNPM.LEERLKLCTKNAD..TPDW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      21|     288|     774|     796|      16
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  757-  785 (20.70/16.30)	KKRKRHIAiDVEterakLHALLnsSTMAP
 1081- 1105 (28.22/15.82)	KAYENMLA.EME.qamkISSKF..STNSP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25245 with Med12 domain of Kingdom Metazoa
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