<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25236

Description Uncharacterized protein
SequenceMNQNQIQQLTSHLSQALDQNYDVVNLEAVLSVICALEGTTITKEQLEATRLAKYINHLRRRTKNEQLARRAKSLLKRWREMVGIQQTATDSQPAPSQPLTAGESAVVVVPSQQSSSPLAPPQLPINLQKNFVDVSLEQQQPLALPTVTVPSSHHTNFSNLINNIASKSDESKPFKFQRESGPIIDHSSNSVSNSTAADRFTDAAIVIDIVSDSNDNDGVVGGGLSVPANVPARNKKLKKDKRRRERESQRPKATLLNRNEVMGQQSRYATKINCAPYKDGKAQAVIPTDAAEILSLSNSSMSSILSGDVTVGNSHSKSMPPRPNNTSELTFAGRFKSVSQPESAVLNGHQFRGTEHLAPITFDDSITNDSNISFSRLSPTPTPSLFPFEERRKALEEAGKQQIEISVLVPPSTTTSSLGNEQSNRSNDFIEGGAASRGILPQIPKKRGRKKGSKGVDSLIAKESSSLSQQIFFGSGVKKVKTTKELFNELQSRKLSNVVQSVNNLSNASSDRDREEALSSRSLQPRPTSSCSEASMHSPQILDTYSSNITLMDADKFSNQNEDIGNTDSDTITSEPSRDSQKSRGNKATSSLESNSNSLQTPSATTGFPNQTHNDVTTQLMHVVHSLGSPPSVGDTEKMYQSQIVPCTCIVVEEEVDPSAEQTISADRLDSEKVTPTGPDSNVLPRDDEAQGDSIQKLERNVADDKTVLPAPQKPIKSIFDLDFDEDDDPLQSIIRDLRPPTVDLEAANGDVKSMMTTSANVITATSGITDGAPVHTDGMDLDQDAAEATLVPLPIFTVHEDPDCMAKERFLVQTNKVTNFHINALHNYCVPNINGNWDGVETASESISSLELYAVTDGADVVPKYGSLTCERIPKDLSGLKFARSISRIKTFKSYLPPFLGVAKCLPTCRRANRQRRRFKESKMQPKSPEISCKLEESESELPFLQLKNENVSIISKSSPSPLQVDVNVGDNIEVVTNFDEGSIDDEIHNNSSFRGPSENENSYNLLKLANDDDLPLEVGANGEMEFRENSRCSSSCSNSSLIKTQQTINAKLRSQQITDQYVIERNRKKRRKTREKEQKPRIKRIKIAINGKVTSQRQISNISSSNNSSDNEDKERGSDTLSLSDDINASQTHSPASNEDEHDDSFQSGTTTFDSIVADEDVDGDGDADGDGDGVLENDYENSDDEEYAIVQRPVACGTSSNHIVLTIKKTPSKINSPNSISAVSPITGSEIVPGSAKKSYFINMIDPNTKPAVQSSSKENEAIVEAEPQLSLENAKPENIIDNRSLLSSQTYCIGSYRRRLHRLRRRRLRIEKSAKLRNTIDIELNHLFISNAERSAPLSETRLHRKLFYNDELCRQNNLGEKERILDYSSSSSSSDNSDIPSDSDEEDNSSSTNEADNIQVAKHKTNIINIETDIKASASKDAAKQEDEEPCESSSDNDNGDDDDFVKEDFANLDTNIEIDTVNNLPLHNNGLLPSFNSICAENPPRSMLPSAALTDEPETNPKPQIASLKSLQNENCDDVNNLYYNNNNLDVIKNSLVPSPILNDSIRESVTSNISSIILASDNKSSIQTNSPGITELIRPDCQTGIRAVAASDKLTSAKEDSRSSQVHQFKEWHQVLQLPSYNDEPLIVLPYVVLE
Length1642
PositionUnknown
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.692
Instability index58.98
Isoelectric point5.08
Molecular weight180384.16
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IEA:EnsemblMetazoa
pericentric heterochromatin	GO:0005721	IEA:EnsemblMetazoa
polytene chromosome chromocenter	GO:0005701	IEA:EnsemblMetazoa

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25236
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     372.44|      95|     287|    1092|    1186|       1
---------------------------------------------------------------------------
  629-  704 (41.67/14.83)	.....................................................................SPPSVGDT.EKMYQSQ.IVPCTCIVVEEEVDPsaeqtisadrldsekvtptgpdsnvlprDDEAQ.GDSIQK.LERNV..AD
  705-  785 (95.48/43.84)	DKTVlpAPQKPIKSIFDLD..FDE......DD.....DP................LqSIIRDLRPPTVDLEAANGD.....VKSMmTTSANVITATSGI.T............................DG.AP.VHTDGMdLDQD.....
 1092- 1186 (164.09/80.84)	NGKV..TSQRQISNISSSNNSSDN......EDKERGSDT................L.SLSDDINASQTHSPASNEDEHDDSFQSG.TTTFDSIVADEDVDG............................DGDAD.GDGDGV.LENDYENSD
 1373- 1459 (71.21/30.76)	...............SSSSSSSDNsdipsdSDEEDNSSStneadniqvakhktniI.NIETDIKASASKDAAKQEDEE..........PCES.....................................SSDNDnGDDDDF.VKEDFANLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.90|      38|     287|      93|     130|       2
---------------------------------------------------------------------------
   93-  130 (67.12/38.83)	PAPSQ.PLTAGESAVVVVPSQQ.SSSPLAPPQLPI....NLQKN
  381-  424 (51.78/28.18)	PTPSLfPFEERRKALEEAGKQQiEISVLVPPSTTTsslgNEQSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.74|      20|      57|    1461|    1494|       3
---------------------------------------------------------------------------
 1461- 1480 (37.88/36.58)	NIEIDTVNNLPLHNN.......GLLPS
 1519- 1545 (32.86/ 8.32)	NENCDDVNNLYYNNNnldviknSLVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     271.13|      83|     265|     224|     341|       4
---------------------------------------------------------------------------
  249-  332 (138.71/111.56)	QRPKATLLNRNEVMGQQSRYATKINCAPYKDGKAQAVIPTDAAEIlSLSNSSMSSILSGDVTVGNSHSKSMPPRPNNTSELTFA
  830-  884 (81.69/36.89)	.........................CVPNINGNWDGV..ETASE..SISSLELYAVTDGADVVPKYGSLTCERIPKDLSGLKFA
 1194- 1234 (50.73/13.38)	QRPVACGTSSNHIVLTIKKTPSKIN.SP...NSISAVSPITGSEI.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.76|      14|     265|     224|     247|       5
---------------------------------------------------------------------------
  230-  247 (20.41/27.30)	VPARNKKlkkdKRRRERE
 1064- 1077 (25.35/ 7.87)	VIERNRK....KRRKTRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.86|      19|      26|     986|    1004|       6
---------------------------------------------------------------------------
  986- 1004 (34.73/22.90)	DDEIHNNSSFRGPSE.NENS
 1013- 1032 (29.13/17.75)	DDDLPLEVGANGEMEfRENS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.63|      50|      61|     462|     521|       7
---------------------------------------------------------------------------
  465-  518 (76.02/48.77)	SSLSQQIF.FGSGVKKV.KTTKELFNELQSRKLSNVVQ.SVNNL..SNAssdrDREEAL
 1288- 1342 (64.61/29.97)	SLLSSQTYcIGSYRRRLhRLRRRRLRIEKSAKLRNTIDiELNHLfiSNA....ERSAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.60|      24|      25|     553|     577|      10
---------------------------------------------------------------------------
  553-  577 (36.39/24.52)	DADKfSNQNEDIGNTDSDTIT.SEPS
  579-  603 (34.21/17.69)	DSQK.SRGNKATSSLESNSNSlQTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      18|     926|     943|      11
---------------------------------------------------------------------------
  926-  943 (30.75/21.52)	QPKSPEISCKLEESESEL
  947-  964 (29.62/20.36)	QLKNENVSIISKSSPSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.31|      17|      18|    1235|    1251|      15
---------------------------------------------------------------------------
 1235- 1251 (30.29/19.75)	VPGSAKKSYFINMIDPN
 1256- 1272 (27.02/16.75)	VQSSSKENEAIVEAEPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25236 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GKQQIEISVLVPPSTTTSSLGNEQSNRSNDFIEGGAASRGILPQIPKKRGRKKGSKGVDSLI
2) GVVGGGLSVPANVPARNKKLKKDKRRRERESQRPKATLLNRNEVM
3) IVVEEEVDPSAEQTISADRLDSEKVTPTGPDSNVLPRDDEAQGDSIQKLERNVADDKTVLP
4) KTQQTINAKLRSQQITDQYVIERNRKKRRKTREKEQKPRIKRIKIAIN
5) LSGDVTVGNSHSKSMPPRPNNTSELTFAGR
6) MDADKFSNQNEDIGNTDSDTITSEPSRDSQKSRGNKATSSLESNSNSLQTPSATTGFPNQTHNDVTTQLMHVVHSLGSPPSVGDTEKMY
7) NIETDIKASASKDAAKQEDEEPCESSSDNDNGDDDDFVKEDFANL
8) RILDYSSSSSSSDNSDIPSDSDEEDNSSSTNEADNIQVAKHK
9) VTSQRQISNISSSNNSSDNEDKERGSDTLSLSDDINASQTHSPASNEDEHDDSFQSGTTTFDSIVADEDVDGDGDADGDGDGVLENDYENSDDEEYAIVQRP
10) VVQSVNNLSNASSDRDREEALSSRSLQPRPTSSCSEASMHSPQILDTYSSNI
399
218
650
1045
305
552
1414
1368
1095
498
460
262
710
1092
334
640
1458
1409
1196
549










Molecular Recognition Features






MoRF SequenceStartStop




1) NLLKL
2) PLQSIIRDLR
3) QTYCIGSYRR
4) SIFDLDFD
5) YFINMI
1006
730
1293
718
1243
1010
739
1302
725
1248