<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25224

Description GK20351
SequenceMAASTQGEIRVGPGHQVNDVYAKLPDYNPISSFPIDKETDERELEESRWSPGVVADGDLLMFLRAARSMAAFQGMCDGGLEDGCLAASRDDTTINALDVLHDSGYDPGKALQALVKCPVSKGIDKKWTEDETKKFIKGLRQFGKNFFRIHKDLLPHKDTPELVEFYYLWKKTPGANNNRPHRRRRQSALRRNRVTRANNNTPPKKEDTPEPQTATTAATATAASETASRSSPAVSKEENSSLTEDDASECDSDSSLTNKRDESPSRMRTRNKQQSNNAGSNSGGTASSVGSGNAANATAGNATTKDQSTGSANAVANGKRPKRGSETPDVGSGGAGSVDSPKTPTKAVAESSATKRKGGKQDTPNKKKRTEQEANEPNVEETATIKEKRKRPDSPVESMNSDSRPDSVLDDGESNTTDTTTAEQQSNKDSKEIISCKEEREIIASDLDIKSEEKTSIKAEIAAEDSKDSAIKNMDEETNIQAPNSVDGLLKEPQIATDAVLPPAVIPVAPPITMKVPTIATVEALNASVDRKEAIEKMENNDNDPELLKKLVTIKQEITPQQQQQQQQSQPPPPMQQQQQQQQQQQPPQQQQLQPMSLQPPPVSVVTQETVYIKKEPMEDSMDATCNQNSNEPQDLKVKIEIKNEDMKINTSGGLPPSAGGPGAPPPNSMHPHVTMNESGQPEPLHLQHMPHGPVPPQPPTGYLIDGQLKYGPPGQPPPPQLHSDPTGVSVGPPGGVSAGGAPTTPQKYPPDMDIKFVPQDLKYQPPPSLDALKYSQEMQAAAAAAAAAAAAAVGKYDIKYMMEQPGKYPVELSNAHQAPPKTGYQDSLKIPDVKPGFGHLPHNVPSPLDVAHKYGPPPTAQDSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPAHQQVPPGATPPPGIAMPKPHYQHDVQTPPLGRPFETGLMIKYGDPLAAKYGPPQPQDLKYPPMPPVSVAGGIVDVKPYGENLIKASPYGPPPESPIDASSRSTPGQDSQGSNSNSQPPSMPPQPQQFQSPHPSPHMPSPAGGGLPPGMHPQNLIHGPPPSGSGPQPPPPPPTSLHQPTPTSAGPPSLQHGLHPGVPHSQISVASSMPPSSIGIPPTLSTMAPSHMHPHMHPHPHLQGLHRPHDMPPTMHPHAPMPMSLQGHPQHGHGLPPSHAPQQQQQQQPQPGGPAGTVRTPSPAQQPPRSMHDPQMVREPPNSQPPTTMAGAGGGGAGSMGPGQGPGPGQMPQQSPHAHRTSPLPGLSGNGPPPPGLIGHPMPIHPHLAHLPPGHPAHAALAHPGHHLLSHSIAGLGPGGGPIALLAGPGGLGGLPESALSRRTPPSHMPHSHASSAPTTPQSVAASNTSTALTTSTVASSAFSRASPSVQISSGAAPAGPGSSTPGGLPNSAAAAAAAAAHRAASPASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALLRQQSPHMTPPPVSNASGLMASPLSKMYAPQPGQRGLGTSPPPHLRPGASPPVIRHPQMPLPLPLIAPGGGIPQIGVHPGQSPYPHPLLHPSVFYPPHHHPFNSPYGYAAYGPGFPAYMKPPPPAGPLDPAAVMAAHHAGLQGPPPQQARQDEQNAAAAAAAAEKQHAAAAAAAQQQLKAPQQQQGPVQNKPPTPKTPQGPTGVPVGMTGPGTPTGLPPGAYPGSHMPGYPPGPPHGSPFAPQDGQPHGLKPTSHMDALRAHAHSANSAGLGGQHHPTEPLPIDIEPDPEPEIPSPTHNIPRGPSPEAKPDDTECHRSQSAIFVRHIDRGDYNSCTRTDLIFKPVADSKLARKREERDRKLAEKERERRQQQQQQQQQQQQQQAAAAQQAAQQAKLKAELKPPYADTPALRQLSEYARPHVAFSPVEQMVPYHHPMGPMYRERELENAQAAAASQSRIDPHWMEYYRRGIHPSQFPLYANPAISQMERERLGIPPPHHVGLDPGEHMPQPPEAGFQLPPNVGQYPRPNMLIPREPHSDVLLRMSYADQLQYLQAAEFQRQSLHDQYFRQRPR
Length2052
PositionKinase
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.882
Instability index76.73
Isoelectric point6.94
Molecular weight218890.47
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25224
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1890.77|     292|     325|     696|    1019|       3
---------------------------------------------------------------------------
  483-  766 (393.42/74.60)	PNSVD.GL......LKEPQIATDAVLPPAVIPVA.........P...PITMKVPTIATVEALNA.SVDRKEAI.EKMENNDNDPEL..LKKLVT....I....KQ....EITP........QQ..QQ................................QQQQSQppppmQQQQQQQQQQQPPQQQQLQPMSLQP...............PPVSVV.............T..QETVYIKK........EP...M...E........DSMDAtcNQNSNE.PQDLKvkieikNE..........DM.KINTSGGL...P..PSA........GG..P.GAP.....PPNSmhphvTMNESGQPEP.....lhlqhmphgpvPPQP.......PTGYLIDGQLK.....YGP.PGQP..PPPQLHSDPTGVSVG..........PPG...GVSAG.GAPTTPQ......................KYP.PDMDIK..FVPQ.DLKYQP
  767- 1092 (472.08/92.88)	PPSLD.ALK....YSQEMQAAAAAAAAAAAAAVG.........KYDIKYMMEQPGKYPVELSNAHQAPPKTGYQDSLKIPDVKPGFGHLPHNVPSPLDV....AH....KYGP........PPTAQDSqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqqQQQQQQ.....QQQQQQQQQQQPPAHQQVPPGATPP...............PGIAMPK............PHYQHDVQTPPL......GRP...F...ETGlMIKYGDPLAA..KYGPPQ.PQDLK......YP..........PMPPVSVAGGIVDVK..PYGENLI...KAS..P.YGP.....PPES.....PIDASSRSTPgqdsqgsnsnsqppsmPPQPqqfqsphPSPH.....MP......SP.AGGG..LPPGMH..PQNLIHG..........PP......PSG.SGPQPP.........................P.PP........PT.SLH.QP
 1099- 1413 (365.70/68.60)	PPSLQhGLHpgvpHSQ.....ISVASSMPPSSIG.........IPPTLSTMAPSHMHP....HMHPHPHLQG....LHRPHDMPPTMH.PHA.PMPMSLqghpQH....GHGL........PPS.....................................HAPQ.....QQQQQQPQPGGPAGTVRTPSPAQQP...............PR.SMHD............PQM...VREPPN......SQP...P...TT..MAGAGGGGAG..SMGPGQgPGPGQ......MPqqsphahrtsPLPGLSGNG........PPPPGLI..gHPM..P.IHPhlahlPPGH.....PAHA.ALAHP.......ghhllshsiAGLG.......PGGGPI..ALL.....AGP.GGLGglPESAL.SRRTPPSHM..........PHS.....HAS.SAPTTPQsvaasntstalttstvassafsRAS.PSVQISsgAAPA.GPGSST
 1414- 1727 (357.28/66.78)	PGGLP.N...........SAAAAAAAAAHRAASP.........ASSVSSLSRQSPLHPVPQSPLSHHPSSSALSAAAAAVAERDRHALLRQQSP..........H.....MTP........PPVSNAS.........................glmaspLSKMYA.....PQPGQRGLGTSPPPH..LRPGASPPvirhpqmplplpliaPGGGIPQigvhpgqspyphPLLHPSVFYPPH......HHP...F...NSP....YG...YA..AYGPGF.PAYMK.......P..........P.PP...AGPL.D....P..AAVMaahHAG..L.QGP.....PPQ........QARQDEQN.......aaaaaaaaeKQHA.......AAAAAAQQQLKapqqqQGPvQNKP..PTPKTPQGPTGVPVGmtgpgtptglPPGaypGSHMP.GYPPGPP......................HGS.P.......FAPQ.D..GQP
 1728- 2023 (302.28/54.89)	....H.GLK....PTSHMDALRAHAHSANSAGLGgqhhpteplPIDIEPDPE.P.EIPSPTHNIPRGPS..........PEAKPDDTE.CHRSQSAIFV....RHidrgDYNSctrtdlifKPVA.DS.............klarkreerdrklaekerERRQQQ.....QQQQQQQQQQQAAAAQQAAQQAKLK..................AELK............PPYA...DTPALrqlseyARPhvaFspvEQ..MVPYHHPMGP..MY...R.ERELE......NA..........QAAAASQSR..IDPHwmEYYRRGI...HPSqfPlYAN.....PAIS..................................................QME.....RER.LGIP..PPHHVGLDPGEHMPQ..........PP......EAGfQLPPNVG......................QYPrPNMLIP..REPHsDVLLRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.49|      17|      21|     290|     310|       4
---------------------------------------------------------------------------
  273-  305 (19.54/15.60)	QqsnnagsnsggtassvGSGNAANATAGNATTK
  329-  346 (24.95/12.32)	D...............vGSGGAGSVDSPKTPTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.98|      19|      21|     223|     241|       5
---------------------------------------------------------------------------
  223-  241 (31.19/18.56)	ASETASRSSPAVSKEENSS
  247-  265 (33.79/20.80)	ASECDSDSSLTNKRDESPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.37|      32|      34|     362|     394|       6
---------------------------------------------------------------------------
  362-  394 (49.19/32.83)	DTPNKKKRTEQ..EANEPNVEETATiKEKRKRPDS
  397-  430 (49.18/28.34)	ESMNSDSRPDSvlDDGESNTTDTTT.AEQQSNKDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.81|      14|      21|     446|     459|      10
---------------------------------------------------------------------------
  446-  459 (23.12/20.16)	DLDIKS.EEKTSIKA
  468-  482 (19.69/15.87)	DSAIKNmDEETNIQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      13|     117|     197|     209|      11
---------------------------------------------------------------------------
  197-  209 (24.72/14.12)	ANNNTPPKKEDTP
  316-  328 (24.08/13.49)	ANGKRPKRGSETP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25224 with Med12 domain of Kingdom Metazoa
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