<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25221

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCMQADMLCVWRRVQSTKQDNTDPNALNFEITTSTKVHPPLSLAAAKELWIFWYGEEPDLSDLVDAELLRIAANQPLWNGTWKGELTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLADAATAFAAASSAQSSGSNGTTGGTTGQNQEPNTNSEPLEAPGSNGETAKASKPAHARKVMLAPFGIAAILTGNSYKATDPMAEKILEDWSSFFPLCNKDNTDVPPVVEVVSGGHKMYHPTKYVLVTDLDDMEQMEFAELDKARSASAAAAVAAAAGETAALASAAATVAVSSSSSAVAASTQAMPLATNNNNNNNNNVSATSAASAASTVSVANAAAIASRKATAPQAISALERLTFQPYYDQRPTSGFSFNTNNTHIPPSAAIEMPERSWQDCIMNTLQIDATATAAAAAAAAAAASSASIGGGGDEDEQNKPPPADSKQLVQQQIQQQQQQQQRQKLWKFVDPMQKAPCICTNAQCGGSSKRHHHHHQQQQQQQQLQPLGSPALRAAGGGNMKSSFHQHHYQRPGTPAPVSSAAVIAAAAAAASAGSHHSTSSTNTNTTNSNNNNNISSTSCSSMMTALKRHIVPFHKRLPNTLTSSSSSSLSSLFKPKTNININNNNNTTDTNIPKQRHLTAGGANAGSGSGIGGTTPHGTAHGGASQYLRNSLGGDSSMPAVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVPNLQQPPTPIDHLLDKNTPAPTPTDQHDNKSITASPYVHQTPSVEPPSYTEHSGGGGGGAGGGTASQPSLSGPGSVQPNTPTASANTPGGGSGGGGGGTTASSGGAASTIATTEPGLSGGSSQRQQSAQREHLRQCCRIHTEALHLLVFTAATMTLKDPDSYYDEEWLKEVVYDFRFQENWDYLPVKRPKLEDPSKQRRPRYSKNLYEGHTHFKPLMPSPGSVYGSQLLSLDLQAAVGGGSGISGGSGTSNDGLVGIVNSSGAGGDEPDNGNNNYFQGLDIKTEPGLLSPSCRETKSSNTGGSSSGGGNNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSTVTNTIDELKRSTAVTSAVVIAAAAAAGLANSGAGSIQAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTSIMATPAVAGTAATATALVPLGISSSVVGGVAIGGVLKVVKQEYNVELGSPVEEPIDDWTYVYRPPQQEKFVGSSRYAPLTNLPSQTLPALNIPPNCFYKPTWSTHKSRAASLAKAAAAQQQQQQHQKHQALQQRIQLHQQQLQMHQHQHQQQQQQQHLQQQQHQQQQQQSAGAGSSHPHQKHQQLQELLLSNAPRTPSTAMPSPSTSTVPQPLSSAGSQLLLNQLNCPQAPPGSSMQQLMRAGMSPISPGPVGVGTVPFPRSSPMHRQTPTHPPPPYPYDLAVVSPATSTSSYLNKQFNSQEPHPHSHTPQGSMHHMQGGAGGGMGIHGSGNGPNGAGSTVGGGASGNSHLSMMHYTGDAGIASGSSSAVSVPSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGGSFNPFPTHSSTSHTANSAAAASSAQRLLNGPSSSSSSSFAGGLRMISAFGGSPASSSMPGAGSGHGHGPNGGSSSSSCTPPSSNPHITGYVDDDPVDCTCGFSAVVNRRLSHRAGLFYEDELEITGIADDPGKNKQPTLLNLIQSLSRRQQGKLMPGETNSSTALEKSTGVATTGQVEQLAHAIFDLLLEQCSIIQTSSSSVHRAVQSHRRRMSRQRRLFGNSGAPAASMASIANVLEFIDAHDVISLALEQARLAFESQRMDNIMDFHGGSNQHSSSQQLTAFQAAPLALRQKLAILGSGRLTVHKWPYLPVGFTRSNKEIVRTMNSIQPMLQNAFHCKSRGGAAGSKDASSYNTVSGPLTWRQFHRLAGRASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYLVVCPDNEHVASCTRSYFRELSSTYEMCKLGRHTPIRGWDGILQVSSSRSGLPNDREGPTPLDDWLRTLEHAPLAEQIRRYAVAFHHQLAPYLSRVATDKTLLNPPDGNSSSSSNIGGAGGSGSSKTGGSGQHLGNSSGTELPTDAAIKLEPGTEQQTPVSSSSGQQQQDNSQDTKPDIKGAGGANGNGSDSKPALILGDPLGVGETLEDINPSAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKVIPDSVRAQMNIQIISLEAVMELGPCGNRKRFSDEIKCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRKAYKMYTAPFVLAPMHERNDKTDFSRAAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGELLEKVCINIDVPNRLRRRKAPARYVALKKLMDFIMGLISQTPQMWRLVIGRIGRIGHSELKSWSYLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLSTPQDVTCTHILVFPTSAVCASFTRQFQNEPPVDDDFLTFEEEGNEEFSDADIGDIFWDTAHMDRVSPTGSPGRMEDNRSWPSAGGNNFKCSPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQIADDMFNQTNAHQSANDHPLDSSLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2867
PositionMiddle
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.441
Instability index53.85
Isoelectric point6.34
Molecular weight306219.43
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25221
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     152.14|      25|      26|    1376|    1400|       1
---------------------------------------------------------------------------
  547-  567 (35.92/20.59)	..QLVQQQI...................QQQQQ........QQQRQKLWK
  568-  607 (24.57/11.24)	FVDPMQKAPCictnaQcggsskrhhhhhQQQQQ........QQQLQPL..
 1376- 1390 (24.81/11.44)	...............Q............QQQQQ........HQKHQALQQ
 1391- 1417 (42.17/25.74)	RIQLHQQQLQ.mhqhQ............HQQQQ........QQQH..LQQ
 1418- 1444 (24.68/11.33)	......QQHQ.....Q............QQQQSagagsshpHQKHQQLQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     561.92|     144|     144|     650|     793|       2
---------------------------------------------------------------------------
  414-  528 (95.14/35.82)	.....................................TN.NNNNNNNNVSATSAASAASTVSvanaAAIA...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SR.K...ATAPQAI..............SALERLtFqpyydqRPTSGFSFNTNN....THIppsaaiemP...ERSWQDCIMNTLQ...IDATATAAAAAAAAAAASSASI
  650-  773 (193.29/81.61)	.......................AASAGSHHSTSSTNTNTTNSNNNNNISSTSCSSMMTALK....RHIV...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PF.H...KRLPNTLTS.........SSSSSLSSL.F......KPKTNININNNNNTTDTNI........P..KQRHLTAGGANAGSGSGIGGTTPHGTAHGGASQYLRNSL
  774-  894 (167.73/69.69)	GGDSSMPAVASVESPATPAPsphPNSAHSQ......PTSVPPAEQLLNMSPHAPTS.VPNLQ....QPPT...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PIdHlldKNTPAPTPT.........DQHDNKSIT.A......SPYV.......HQTPSVEP........P..SYTEHSGGG...GGGAG.GGT.........ASQ...PSL
  895-  957 (50.31/14.90)	SGPGSVQPNTPTASANTPGG..gSGGGGGGTTASSGGAASTIATTEPGLSGGSSQRQQSAQR....EHL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1521- 1589 (55.46/17.30)	......................................................................rqccrihtealhllvftaatmtlkdpdsyydeewlkevvydfrfqenwdylpvkrpkledpskqrrprysknlyeghthfkplmpspgsvygsqllsldlqaavgggsgisggsgtsndglvgivnssgaggdepdngnnnyfqgldiktepgllspscretkssntggsssgggnnlftaeglnpslndleqlfetssndecssvqihtppdsnnpsnggcstvtntidelkrstavtsavviaaaaaaglansgagsiqaedltkmfptppsheqqhpnsspcqtdvvmtdlsvdttsimatpavagtaatatalvplgisssvvggvaiggvlkvvkqeynvelgspveepiddwtyvyrppqqekfvgssryapltnlpsqtlpalnippncfykptwsthksraaslakaaaaqqqqqqhqkhqalqqriqlhqqqlqmhqhqhqqqqqqqhlqqqqhqqqqqqsagagsshphqkhqqlqelllsnaprtpstampspststvpqplssagsqlllnqlncpqappgssmqqlmragmspispgpvgvgtvpfprssPM.H...RQTPTHPPPpypydlavvSPATSTSS...........YLNKQFNSQEPHPHSHT........PqgSMHHMQGG...AGGGMGIHGSGN................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.78|      20|      24|    1745|    1764|       3
---------------------------------------------------------------------------
 1049- 1069 (23.15/ 6.13)	GSQLLSLDLQAAVGGGSGIsG
 1746- 1766 (34.10/13.19)	GSPASSSMPGAGSGHGHGPnG
 1767- 1784 (27.42/ 8.89)	GSSSSSCTPPSSNPHITG...
 2223- 2243 (29.11/ 9.97)	GNSSSSSNIGGAGGSGSSKtG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.27|      35|     645|    1136|    1191|       4
---------------------------------------------------------------------------
 1087- 1128 (55.77/17.55)	AGGDEP.........DNGNNNYFQGLDIKTEPGLLSPscretksSNTGGSS
 1138- 1181 (58.49/53.41)	AEGLNPslndleqlfETSSNDECSSVQIHTPPDSNNP.......SNGGCST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      21|      24|     256|     279|       5
---------------------------------------------------------------------------
  259-  279 (36.60/22.95)	TNSEPLEAP.G....SNGETAKASKP
  281-  306 (25.80/ 6.59)	HARKVMLAPfGiaaiLTGNSYKATDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.65|      14|      15|     371|     385|       6
---------------------------------------------------------------------------
  371-  384 (22.66/ 8.24)	ASAAAAVAAAAGET
  388-  401 (21.99/ 8.91)	ASAAATVAVSSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.17|      10|      24|    1701|    1710|       7
---------------------------------------------------------------------------
 1701- 1710 (19.39/ 9.72)	PTHSSTSHTA
 1726- 1735 (17.78/ 8.12)	PSSSSSSSFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      11|      31|     585|     595|       8
---------------------------------------------------------------------------
  585-  595 (24.17/12.06)	GGSSKR..HHHHH
  617-  629 (19.43/ 8.23)	GGNMKSsfHQHHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.99|      13|      24|    1461|    1474|       9
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 1461- 1474 (20.16/12.26)	PSTSTVPQpLSSAG
 1488- 1500 (23.83/ 9.49)	PPGSSMQQ.LMRAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.55|      23|      24|    1277|    1299|      10
---------------------------------------------------------------------------
 1263- 1287 (25.01/10.88)	AVAGTAATATAL..vpLGISSSVVGGV
 1288- 1312 (26.22/11.76)	AIGGVLKVVKQEynveLG..SPVEEPI
 1314- 1331 (24.32/10.38)	DWTYVYRPPQQE....KFVGSS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      16|     167|    1192|    1207|      12
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 1192- 1207 (25.66/12.87)	STAVTSAVVIAAAAAA
 1360- 1375 (25.68/12.88)	STHKSRAASLAKAAAA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.63|      37|    1346|     308|     345|      13
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   48-   96 (52.97/31.63)	ADPILRSYSRCMQadmLCvwrrvqstKQDNTD.PNALNFeITTSTKVHPP
  308-  345 (66.66/46.41)	AEKILEDWSSFFP...LC........NKDNTDvPPVVEV.VSGGHKMYHP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25221 with Med13 domain of Kingdom Metazoa
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