<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25217

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEEWQTQKFRQNVISKIHDMLPQNGQDPNKNASMMESHIFRKSRTKDEYLGLVAKLFMHYKDMSQRKSQQQQQQQQQQQQQPQGGPPNAEMGQQSMIPDPLNALQNLASQGNRNPQLMPMSSGGVGVGVGVGVGVGGGPVPNQMTGPVGPGTASNLLQSLNQQRPGGQQQMPTMPNIRGQMPMGGVGVGGAGPQQQQQMVQVQQMNVMAGGGGGAGVPGNQSLQGMPNQMVGPGPNSGPLPSGPGGGVGGNVGGASVGGGPGGGPPMNVNSMQQMPMQQMQQNQMAMGMNPMMRLQQGGNGMGQNMPGMPPNMQPTVGQQQQQIGGGGGMVNVPNMPPNLQQQQKPNPMAMGQVVGPGGQMFPVGVGNRGPQQQQQPGQQQQQQQQQPGQQQQQPPFMRSSPSPADAQQQQQQLQQQQLQQLQQQQQQQQQQQQQQQPLTPQIPTPQMIPSPALVPQSSPVQMQMLQQQNSQNRNIRQQSPSASINTPGQIVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMAKMSKLLEILCNPSQRVPLDTLLKCEKALEKMDLVSYSGQQFGKSSNPLLEVITTTLQSPLANHTLHRTFRPSLELLFGTDISAPKKPRVEEKKPNFEYFHQEVPHVLQGEIARLDTKFKVKLDTTAQNTNKSISLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLYSQEYSATPFLQLVQQSLSARISKLPKNYSLSHLLDTWEMAVRQACSPNASKLNPVTINELTTLLGV
Length773
PositionTail
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.749
Instability index73.08
Isoelectric point9.39
Molecular weight84158.73
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25217
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     591.17|     110|     353|      23|     144|       1
---------------------------------------------------------------------------
   23-  144 (199.37/67.42)	PQNGQDPNKNASMMESHIfrksrtkdeyLGLVAKLFMhyKDMSQRKSQQQQQ...QQQQQQQQP...QGGPPNAEMGQQSMIPDP..........LNALQNLASQGNRN.PQLMPMSSG.GVGVG..VG...VGVGVGGG..PVPNQ
  197-  267 (79.15/14.54)	...............................................QQQMV...QVQQMNVMA...GGGGGAGVPGNQSLQGMP..............NQMVGPG....PNSGPLPSGpGGGVGgnVGgasVGGGPGGG..P.P..
  269-  337 (99.73/22.84)	.........NV............................NSM.....QQMPM...QQMQQNQMA...........MG..................MNPMMRLQQGGNGM.GQNMPGMPP.NMQPT..VGqqqQQIGGGGGmvNVPNM
  338-  424 (126.08/31.46)	PPNLQQQQKPNPMAMGQV..........VGPGGQMFP..VGVGNRGPQQQQQpgqQQQQQQQQPgqqQQQPP...FMRSS..PSP..........ADAQQQ..QQQLQQ.QQLQQLQ..............................
  425-  502 (86.84/17.06)	................................................QQQQ...QQQQQQQQQ...QPLTPQIPTPQ..MIPSPalvpqsspvqMQMLQQQNSQ.NRNiRQQSPSAS.....IN..TP...GQIVTGNS..PFNPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     253.88|      68|     130|     547|     618|       2
---------------------------------------------------------------------------
  547-  618 (103.31/64.58)	ILCNPSQRV....PLDTLLKCEKALEKMDLVSYSGQQFgkSSNPLLEVITTTLQSPLANhtLHRTFRPSLELLFGT
  625-  662 (44.76/19.79)	....................KPRVEEKKPNFEYFHQE...........VPHVLQGEIAR..LDTKFKVKLD.....
  675-  743 (105.81/55.71)	ICCLDDKRLpsvpPVSVSVPEEYPWQAPDCSLYS.QEY..SATPFLQLVQQSLSARISK..LPKNY..SLSHLLDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.56|      11|      24|     509|     519|       3
---------------------------------------------------------------------------
  509-  519 (18.71/13.99)	EKYKQLTKYIE
  536-  546 (17.85/13.02)	EKMAKMSKLLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25217 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GVGVGVGVGGGPVPNQMTGPVGPGTASNLLQSLNQQRPGGQQQMPTMPNIRGQMPMGGVGVGGAGPQQQQQMVQVQQMNVMAGGGGGAGVPGNQSLQGMPNQMVGPGPNSGPLPSGPGGGVGGNVGGASVGGGPGGGPPMNVNSMQQMPMQQMQQNQMAMGMNPMMRLQQGGNGMGQNMPGMPPNMQPTVGQQQQQIGGGGGMVNVPNMPPNLQQQQKPNPMAMGQVVGPGGQMFPVGVGNRGPQQQQQPGQQQQQQQQQPGQQQQQPPFMRSSPSPADAQQQQQQLQQQQLQQLQQQQQQQQQQQQQQQPLTPQIPTPQMIPSPALVPQSSPVQMQMLQQQNSQNRNIRQQSPSASINTPGQIVTGNSPFNPQEEAL
2) QKFRQNVISKIHDMLPQNGQDPNKNASMMESHIFRKSR
3) YKDMSQRKSQQQQQQQQQQQQQPQGGPPNAEMGQQSMIPDPLNALQNLASQGNRNPQLMPMSSGGV
129
8
61
506
45
126










Molecular Recognition Features






MoRF SequenceStartStop




1) YLGLVAKLFMHYK
50
62