<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25212

Description Uncharacterized protein
SequenceMLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAHNSNVNASKVSAFFSGVLAKKEELMTLQDTGRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTGNMIKFMKELLPKLQEYYQQDHHKPAANGNQSAGLTGGSGPGMGVTTNGNTSSGSGAVSNAVAPCSGQPNVIPVPSMASPLPPIHSPANGGAPGATGPPGSGGVNSAGNVMPPAGSGGSIPPGSSSSSSTASGVAVGAAAVPPGSTISGIGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLLDKMRTQTSFDEPLKKLVLSFALQYMHDFVQSERLCRKMAYIVAKKLAHLLNSAVEQQGLKELEAGGGEKAQNHHQNHHHPDPYELALQEQMNCPHHRDIVLYLSTILQIITIECPTALVWSGIAAHRAPSSLVGSPLDHLPLAPSVLPMPTRCPRTNQELRRQLRAAEADIVVRTQHAEQNWFASKWLSAGKNHYTSVLATLDYLDTHCFERMDQCNSMDTLYAHIFPSKRREDSEPVAVVSGSDQQQQQQSQRPSYEPKQDKDTVRILCEWAVSSQRWGEHRAMVVAILLDKRQIDVTSTPAEQSNDKEDKDSLASGAGLIDGLPVFQHVLMQFLDHDAPVLDEHSSSPQQRTEFTNLVQLFSALIRHDVFWHNAYMHTLISRGDLLLESTLVNKSSVATSKTSPPPPAPPPPTTSHGFDDDGFGGGLDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGDGNGTGNGHSTPPISRHYVYTKHFPIPQDDPSMASYSTESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQHMAYFDQHVVTAQCAANILEQLNGFASGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDNLLKELPEVEHQLQLKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTMSVFEGLCRTIRHVNNPSECSSAERCILAYLSDLHESCVLLQGKEQSNEYYQQLQCIKRFKDIFNTPEQLGLPPQGYNPQFLQEVFLAPRRGGKIEAHWLRQLHESPANVYSFVSNALIAVCRETDNERLNDMALACAELTASCNVLSEEWIAALQSLCSGSKSPRYPHLGGQVDIGQGRTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSSGAGVGSVSELSGDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGSDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPMGSTVGGLGSSSVGGGAFGSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSTSLTSEQEALQQPSVGGLEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRAMIVRILENLGQWTLRISWLDLQLMYRQSFSNTAELNVWLDTVARAAIDVFHMEEVVLPGALKATHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVPKSDCNSSGSGDEREKSNSCHSSNSYGLGGVATRNKKMPLNYQPFLGLILTCLKGQDEYKENLLVSLYSQLSQCLQSFAELDTIGGVDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDENKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMDKKQLRISDKQRISVWDILEGHKNPAPFSWVWFGAVKLERKPLTYEDAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEMMKADTPSSVDQSPSAVGVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQGQQPQLAPQPQQQQQQQQQMQQQQQQQQQQQQQQQQQQQLNMQQQQMQNNQMGQMQMNMPMNMQQFGPNPNAMMQQQNAMMQQQQQMQQMTPNQLQQQLNVGGGNGPLNQQVNFMQQGPGAGPGGPGLGGGPQQQQWHNAPQQQQTPQQYHNQYNPHQQNMQMNRIERPPQNTNSKQALSQLLRQRAPSSFQQTQQQQQQQQGVGGFNPMQQQAQQQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNTMMQQQMAQGMVGMVGNPNANQLMQSGGVQGGNGVGVGVGVGVGVGVGVGNNPNMGVNVGVGMGAMPQQGMMQQQPQQQVQFQNFQNQYQQQQQQQQQQQQGMQQQGGGAGIGVGVGVGVGVGVGMGPNQQQQQQANLMGNFNPQMQQANRNNPEFMAAAAVQQQQQQQQQQQRGNMPGSMMGGNRGQYMNQAPNVTMSNMMGPGPGGVGVGQVPPYARQQQAGGGKPGVLPTQQQFQQQQQQQQQLRHQQMMQMQGMGGGGGVGVGMGGGPQAAGGANAVGGGGMGVGVGVGVGVGVQQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
Length2587
PositionKinase
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.06
Grand average of hydropathy-0.534
Instability index52.47
Isoelectric point7.66
Molecular weight284375.70
Publications
PubMed=17994087

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblMetazoa
mediator complex	GO:0016592	IEA:EnsemblMetazoa
polytene chromosome	GO:0005700	IEA:EnsemblMetazoa

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:EnsemblMetazoa

GO - Biological Process
chaeta development	GO:0022416	IEA:EnsemblMetazoa
compound eye development	GO:0048749	IEA:EnsemblMetazoa
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IEA:EnsemblMetazoa
imaginal disc-derived leg segmentation	GO:0036011	IEA:EnsemblMetazoa
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa
sex comb development	GO:0045498	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25212
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     807.37|      71|      71|    2285|    2355|       1
---------------------------------------------------------------------------
 1963- 2039 (105.45/31.54)	.....DQSP...SAVG.VGTGRGRGKGTTTrkrkP.KNP.K......TPPV..........V.NTQQGQQPQlapQ...PQQQQQ.QQQQMQQQ...QQQQQQQ...............QQQQQQQQ
 2040- 2099 (74.31/20.12)	QlnmqQQQM.qnNQMGqMQMNMPMNMQ.QF....G.PNP.N.......................A.M..MQQ...Q..nAMMQQQ...QQMQ.Q...MTPNQLQ...............QQ......
 2100- 2164 (69.17/18.24)	.........................LNVGG....G.NGPlN......QQVNfmqqgpgagpG.GPGLGGGPQ...Q...QQWHNA.PQQQQTPQ...QYHNQYN...............PHQQNMQM
 2165- 2220 (62.10/15.65)	N....R.............................iERP.P......QNTN..........S.KQALSQLLR...QrapSSFQQT.QQQQQQQQgvgGF.NPMQ...............QQAQQQQQ
 2221- 2279 (79.38/21.98)	Q....QQFMrggN........MRPGMAPNQ....M.NQM.N......M...............G.GQG.MSQ...N...TMMQQQmAQGMVGMV...GNPN..................ANQLMQSG
 2280- 2350 (143.93/45.64)	G....VQGG...NGVG.VGVGVGVGVGVGV....G.NNP.N......MGVN..........V.GVGMGAMPQ...Q...GMMQQQ.PQQQVQFQ...NFQNQYQ...............QQQQQQQQ
 2351- 2422 (99.10/29.21)	Q....QQGM...QQQG.GGAGIGVGVGVGV....G............VG...............VGMG..PN...Q.......QQ.QQQANLMG...NFNPQMQqanrnnpefmaaaavQQQQQQQQ
 2423- 2498 (106.65/31.98)	Q....QQRG...NMPG.SMMG.G.NRGQYM....N.QAP.NvtmsnmMGPG..........PgGVGVGQVPP...Y...ARQQQA.GGGKPGVL...PTQQQFQ...............QQQQQQQQ
 2537- 2583 (67.27/17.54)	........................GMGVGV....G..........................V.GVGVGVQQQ...Q...SMNQQQtPNLVAQLQ...R.QNMMG...............QQQQYQHQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25212 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDGDGNGTGNGHSTPPISRHYVYTKHFP
2) DIEPVPEKICIKDEMMKADTPSSVDQSPSAVGVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQGQQPQLAPQPQQQQQQQQQMQQQQQQQQQQQQQQQQQQQLNMQQQQMQNNQMGQMQMNMPMNMQQFGPNPNAMMQQQNAMMQQQQQMQQMTPNQLQQQLNVGGGNGPLNQQVNFMQQGPGAGPGGPGLGGGPQQQQWHNAPQQQQTPQQYHNQYNPHQQNMQMNRIERPPQNTNSKQALSQLLRQRAPSSFQQTQQQQQQQQGVGGFNPMQQQAQQQQQQQQFMRGGNMRPGMAPNQMNQMNMGGQGMSQNTMMQQQMAQGMVGMVGNPNANQLMQSGGV
3) GMGPNQQQQQQANLMGNFNPQMQQANRNNPEFMAAAAVQQQQQQQQQQQRGNMPGSMMGGNRGQYMNQAPNVTMSNMMGPGPGGVGVGQVPPYARQQQAGGGKPGVLPTQQQFQQQQQQQQQLRHQQMMQMQGMGGGGGVGVGMGGGPQAAGGANAVG
4) GVNVGVGMGAMPQQGMMQQQPQQQVQFQNFQNQYQQQQQQQQQQQQGMQQQ
5) LVNKSSVATSKTSPPPPAPPPPTTSHGFDDDGFGGGL
6) MLSMLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTTPPLSDEFGTAH
7) QPNVIPVPSMASPLPPIHSPANGGAPGATGPPGSGGVNSAGNVMPPAGSGGSIPPGSSSSSS
8) QQQQSMNQQQTPNLVAQLQRQNMMGQQQQYQHQPPPY
9) YYQQDHHKPAANGNQSAGLTGGSGPGMGVTTNGNTSSGSGAVSNAVAPCS
819
1939
2377
2308
770
1
252
2551
201
875
2281
2534
2358
806
56
313
2587
250










Molecular Recognition Features






MoRF SequenceStartStop




1) RYILLF
893
898