<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25210

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGNNAKGPSGSTAGAGGFGSHIPSIEEKNKQIQQETMMEKLRAKYRSKPKSYEEIKKSVRMYFIEKHYPLDPLCKATLQAALDKLQHYIKVTSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDSSGNLSDVKVHHECKIEQQSSELVNCLKSGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDIYNLYQMQNHKGDDSYEIMNQSSVGLVLQRRGGHPMKLTYFCPPIHLPECKAGGASPTHTNEVNSLNYTIDQVMKSSHGLSATVNLEGSSANKLQIMPIVTFQRDAQSGIEVPTYAQLNQNNSMLMPATYVLRLNKPLPVCYESLRALGLPGVDGMANISTSASTSTTGFSSSTSTPQGPATTVLNLIVQTASKQAIRNTQRGLYVNLPKETHCYFFTDNRKLQGTLVSSLPFTEPAQVPKIMAFLKKQALFYTLLSSCVREQQKQYNDMDSTVILEVTAVSFNQITVELQHPYEESLATVDFLLENNQVTCSVYCLSNDYEELSQKLTRTVRKVISIPMVIYKLLKCWDEEHQVKLHGGIATGTSAGGAGGGAGAGSGLGGPIGGAAIGSSGTTSFNQFAMDTSTGGGLPDGSLPSGGFANVNNLKMDAKVRSLVDGFAASTSAAAAIAGLINLKRETDPEVTGGSSSSGVGGGSGSTTTTGSSSSSGQVKASDQEIADKYKNIWKDKTPNLKHCVSITPIPGDASKTGSGSATAASGAGVTPSVGAITGGGAASAQPSSVEVQRTGGIEIIPLNVQASVGGGGSSGTASSSAAPTTITITPITGKDSSKEPSKKSSSSSSSGGPSGSGSVATKRPHESSSSSGSSSSSSSSSGSSSSSTGGGGGGGSSSSSSTDTQKEKKRKKKRDDSPMGPPEKVYSRQNSPAAGGDASTTSGVVRKFSSPSSSPKAGGAGGGLMSGVPPTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHGSSGKPSMSTLKSAATAATSLSPKGDKSSGSSGSTSVSGSSSSVTAVTSTGSGGNSSLVRSFASVSAPPPPPPVPPLSSSQQQAAAAAAAAAAVSSSLKKEKSTSSGGGVSATSSAATTSKTSVASLSHLAAGFGAPPGSIGGPGGPGAVAGGVGVGTSSSGATAASALELGALRKGMAGGAVSLMTSTAALTTTLQPGSVAASSAGTTGVTSSTVSATAVLAGMGVPTSSVGLGLGMPTTGTGTTALPPSCSSTSSDAASLQAGVGGGGGGGVSSSEYMVKPSSQEGLKLTINKTGSSKSNLSSGSGGGSTSSTSSSSTTSSMSSTSASSIGSSKAKSLSSGTSSTGGGGSSSSSSGSSSSTKKQHTGLKPGVNSGPASKKAHSSVSGGTSGTGGGGSSTSSSSSSSSSSKHLFQKANSSGNLSTKLGSSSVGGGGGGSSSSGGTTSGGVPLTKSHSTNSFPEHSGPRRRPSMGALATSGSAGASGSQRKASGSSSMGGGSGSSSSGAVSPAALTGSMSQPPPRFDHHTDMMTILQYASPTMAASMEGFIKGLHNKFQIPKLSQRASGGSGSAGATGGSSGSSGPTGGRTTPSTTEQTSTTSSSSSTAATTSGSICSSNVGPGGLGALQEQQLQQEGPKPPQAGPPPPSSSAGGGAAQSATTTGATGAASSATGGSSDLLLNLSSSATTMPTNDGIDEELLARIAGE
Length1687
PositionMiddle
OrganismDrosophila willistoni (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.338
Instability index55.32
Isoelectric point9.38
Molecular weight167691.23
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25210
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1255.14|     427|     459|     667|    1125|       1
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  555-  734 (184.69/15.40)	..................................................................................................................................................................................................................................................................HQVKlHGgiATG.TSAGGAGGGAGAGSGLgGPIGGAAIGSSGTTSF....NQFAMDTSTGGGlPDGSLPSgGFANVNNLKM................................DAKVRSLVDGFAASTSAAAAIAGL.INLKRETDPEVT..GG..................S.........................................SSS..GVGGGSG.STTTTGSS..SSSGQVKASDQEIADKYKNIWKDKTPNLKHCVSITPI..PGD..ASKTG.SG
  735- 1189 (667.46/96.39)	SATAA.SGAGV.TPSVG.....AITGGGAaSAQPSSVEvQRTGGieiiPLNVQASVGGGGSSGTaSSSaaptTITITPitgkdSSKEPSK...KSSSSSSSGGPSGSGSVATKRPHESSSSSGSSSSSSSSSGSS.....SSSTGGGGGGGSSSSSSTDTQKEKKRKKK.RDDSPMGPPEKvYSRQNSPAAGGDASTTSG..VVRKFSSPSSSPKAGGAGGGLMSGVPPTRPSPkhsPVYSSpkHNTASnspkspFGTHSPK.HG..SSGKPSMSTLKSAATAATSL.SPKGDKSSGSSGSTSVSGSSSSVTAVTSTGSG.GNSSLVR.SFASVSAPPP................................PPPVPPLSSSQQQAAAAAAAAAAVSSSLKKEKSTSSG..GGVSATSSAATTSKTSVASlSHLAAGFGA......PPGSIG..........GP....GG......pgAVAGGVG.VGT.......SSSGATAASALELGALRKGMAGGAVSLMTSTAALTTTlqPGSvaASSAGtTG
 1196- 1391 (180.01/15.47)	SATAVlAGMGVpTSSVGlglgmPTTGTGT.TALPPSCS.STSSD....AASLQAGVGGGGGGGV.SSS....EYMVKP.....SSQEGLKltiNKTGSSKSNLSSGSGGGSTSSTSSSSTTSSMSSTSASSIGSSkakslSSGTSSTGGGGSSSSSSGSSSSTKKQHTGlKPGVNSGPASK...KAHSSVSGGTSGTGGGgsSTSSSSSSSSSSK............................................................................................................................................................................................................................................................................................................................................
 1394- 1658 (222.98/22.90)	......................................................................................................................................................................................FQKANSS...GNLSTKLG........SSS....VGGGGGGSSSSGGTTSGGV...PLTKS..HSTNS......FPEHS....G..PRRRPSMGALATSGSAGASG.SQR..KASGSSSMGGGSGSSSS.GAVSPAALT.G..........SMSQPPPrfdhhtdmmtilqyasptmaasmegfikglhnKFQIPKLS...QRASGGSGSAGATGGS.....SGSSGptGGRTTPSTTEQTSTTSSSS.STAATTSGSicssnvGPGGLGalqeqqlqqeGPkppqAGpppPSS..SAGGGAAqSATTTGATgaASSATGGSSD..........................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25210 with Med1 domain of Kingdom Metazoa
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