<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25198

Description "Uncharacterized protein, isoform A"
SequenceMMADHLDEPPQKRAKIDQSTLRFLEENLPDELVSSNSGWSDQLSTTGGGVNVVSTATGVGTGGPNKPPTQGPGSGVVPPQMNGAGGGGDDGSGNAGSGAAGSQLRQMQHHQHLQHFLQQQQQGNKGAGGGMVVPGMNQLGSKSPSLQSPNTGGIQVTTQMGMVNSMPMSISNNGNNGMNAIPGMNSIAQGNLGNMVLTNSGGMGTIGGTGLVNTLKQPVAASLMNAVPGSVGVSSVSGAAPSQGMHMQNGPMMGRMVGQQHLLRGPHLMGAGASGGSGPGGVVGVGGGPRMQNPNMQLGQINNMPYGVGNYGTPSSNNPQQQQQLLAQQMAQRGGGGVVAPNMSAGMPQGNRPIGTVVPMSSLGGDGPPPGSGGLVGNPQQQQQLAAANAQMNPQQQQQPPSAQQSALGPRAPQPNQLLGHSQQQQQQPGTSQQQAISSGVASSVSGPAPAPGSMSDERKKQIQQHLMLLLHAHKCNRRENMNPNREVCSVNYCKAMKAVLAHMATCKQSKDCTMQHCTSSRQILLHYKTCQRSDCIICYPFRQNHSLFQNASGAGGGPTGAANASPLQQQQQQQQLAQGQPQVSQNPSGVGVGVGVGVDSKQVAQSTGTGGTQNTAIVLPQQQTPGATNVPKSNTDLAQQQQQQVQQQELRRFESVGSIGQVGPVSAGMLGVPGQGMPPGIRMQGTPSVRVLGVQPGAGGAISGGVPVPGQNVLPGANDVTSLQQQQAQAAQQGGQLMLQGCNTSTGRRRAIPNMVEQQPNAQQSVQQQQQLGNIPAPLSVNVGFNNANFVGVGEKQQLGSQSDQMAKLKLQAQSQAQVQAHVSVVSAGAPGTGNSTAGASVLMPADTTGVANSSSSGSNSSNAGAGSAGSAGGAGGAPGSGSDSEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQHQQQMLQMQQGGPNSGVVNPTSVPNNSLQQQPGQGVRPIISPMGSGGGGPSGMVQQQMRPQAPGMGSGASQQQTAAGQANMVAVAASMRSHSPGGNMLAIQQQQQRMQFPQQQQPVQGNMLVGPSGPSPGGMVANPVLSPFNTQQTMQSASSVGGGPGILTSPVTAQQQQQQQQQQQQQQQQQQFINANGSSGGQNSQISEIMKQRLLQQHQQQTNAAMLLPQSPFSNATPIQQPQQLQQQSNAFNSPMQQKAQQPPGSVLNNMPPTPTSLDALTAGAPNAGAGGIGSGTVTAPSPSPSFMSNGPIGTPSNNPPSVSSLMQPLSNRAATPPYIPTSPVPATSASGLAASSTPASAAATCANSGSSSNISSTSSSVITTTAVTAVVSTPISCASGATQTSTTATSGNVNSTPVSSTVLLVARSNSDNTATGRVMSTSSSLSSQMAALEAAARDNDDETPSPAGANDTNGSNGGGSSGGGGMSSKGKLDSIKQEDEIKKEFMDDSCGGNGDSSQMDCSTGGKGKNVNNDGTSMLKIDLKSEDGAAGDVKIKSEPMDVDESAVVGGIATGANGDGGGGSDGKDDINGAIDGVSAGIASDIKIKSETKPMVPEPLAPNAGDKKKKCQFNPEELRTALLPTLDKLYRQEPESVPFRYPVDPQALGIPDYFEIVKKPMDLGTIRNNILNGKYSDPWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCYGKQLCTIPRDAKYYSYQNSLKEYGVASNRYTFCQKCFNDIQGDTVTLGDDPLQSQTQIKKDQFKEMKNDHLELEPFVDCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKRLPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEGGEMMQEFPYRAKALFAFEEVDGIDVCFFGMHVQEYGSECPAPNTRRVYIAYLDSVHFFRPRQYRTAVYHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDKGMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQAEAAEAAAAANLFSAEDNEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNEHQSGNDLSAKIYATMEKHKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHYEFSSLRRAQFSTLSMLYELHNQGQDKFVYTCNNCKTAVETRYHCTVCDDFDLCTVCKEKVGHPHKMEKLGFDLDDGSAPADLKQANPQEARKQSIQRCIQSLVHACQCRDANCRLPSCQKMKRVVQHTKNCKRKTNGGCPICKQLIALCCYHAKHCQEQKCPVPFCPNIKLKLKQQQLQQKLQQQQLLRRRVALMSRTAAPTALPGPAVSGPVVAAGGVGVGVPVVGMSGVAVSQQVMSGPASILPSSGGGMSPSTVPVPSPVSGAVIAGMTSPHPHQPGIGMKPGGHSPSPNVLQVVKQVQEEAARQQVPHGGSFGKGVPMAPPVMQRPMGVGVPNQGAMGGMVGNQLTGNVGVVPGGGQMPSGGNCNNVLNSNNLLPMDQWGGGGGPQQRYANNTPNQQGMRQPNQLMQQNIQQQQMLGIPSNQLGVGVGVGGSVGTGQMPVVGAGVSMGGGGAAHGIGLGAPIGAATSGGGVRPPGAQGVGGGGTGGAGPNMVNGPPLNTQTLAQIMQKIKNNPTNESNQHILSILKQNPQIMAAIIKQRQQSQINAAAGGAGGAGGALQAGNGPQTPQQQQQQQQVMQQQQMQHMMNQQQQGPGPGPQQMGPGQQQQVSLMQGAQQPQQGPPHQRMANMQNTAMMLPNLPPGITNQGGMVPNQNWTKMRYMQMNQYPPPYPQRQRGPHMGVAGQPQFPGGTTGNFNAGSAGNVTGVQVAGTTVGSGAAGTVSDQYSMANAAASNMLQQQQTVGGAGVKPVPQQQQQQMGVIPPGMQQQPMQQQQQQQMMQAVAAGGGGMTGTNPQNALPGGSSGPTGPGSNVMGPPTPHTLQQQLMQTARSSPPIRSPQPTPSPRSAPSPRGPSASPRAQPSPHHVMSSHSPAPQGPHDGLHNHGMHHQSPLPAVPQDVGVSGVSVGVNAGNVGNAGGSLPDASDQLSKFVERL
Length3142
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.567
Instability index54.97
Isoelectric point8.98
Molecular weight330332.70
Publications
PubMed=17994087
PubMed=18057021

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro
rhythmic process	GO:0048511	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25198
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            15|     894.46|      65|      65|    1059|    1123|       1
---------------------------------------------------------------------------
   54-   93 (43.37/ 6.44)	.........................S..T.......A............TGVG..TG.....GP.........N...................KP....P........TQG...........PGS...G....VVPPQ.M........NG...................AG....GG...GDDGSG
  290-  379 (59.20/12.70)	RMQ..............NPNMQ..LG..Q.......I............NNMP..YGvgnygTP..S.....SN.................NPQQ....Q........QQLLaqQMA.....QRG..GG..gvVAPNM.SAG...mP.QGnrpigtvvpmsslggdgppPG....SG...GLVGNP
  388-  453 (61.31/13.53)	ANA..............QMNPQQQQQppS.......A........qqsaLGPR..AP.....QP........NQ...L............LGHSQ....Q........QQQQ..PGT.....SQQ..QA....ISSGV.ASS....V.SG...................PA....P.......APG
  604-  674 (52.64/10.11)	VAQ..............STGTGGTQN..T.......A..ivlpqqqtpgA.....TN.....VP..K.....SN...T............DLAQQ....Q........QQQV..Q.Q.....QEL..RR....FESVG.SIG....Q.VG...................PV....SA...GMLGVP
  721-  791 (55.35/11.18)	VTS..............L..QQQQAQ..A.......AqqggqlmlqgcnTSTG..RR.....RA..I.....PN...M..............VEQ....Q........PNAQ..QSV.....QQQ..QQ....L.GN..IPA....P.LS...................VN....VG...FNNANF
 1045- 1109 (100.14/28.89)	QQT..............AAGQANMVA..V.......A............ASMR..SH.....SP..G.....GN...M............LAIQQ....Q........QQRM..QFP.....QQQ..QP....VQGNM.LVG....P.SG...................PS....PG...GMVANP
 1110- 1170 (81.67/21.59)	VLS..............PFNTQQTMQ..S.......A............SSV...GG.....GP..G...ilTS...P............VTAQQ....Q........QQQQ..Q.......QQQ..QQ....QQQQQ.FIN....A.NG....................S....SG...G..QNS
 1171- 1237 (64.69/14.87)	QIS..............EIMKQRLLQ..Q.......H......qqqtnaAMLL..PQ.....SP..F.....SN...A............TPIQQ....P........QQ.L..Q.......QQS..NA....FNSPM.QQK....A.QQ...................P.....PG...SVLNNM
 2433- 2496 (46.98/ 7.87)	SGV..............AVS.QQVMS..G......pA............SILPssGG.....GM..S.....PS...T............VPVP......................S.....PVS..GA....VIAGM.TSP...hP.HQ...................PGigmkPG...GHSPSP
 2566- 2639 (46.19/ 7.55)	MPS..............GGNCNNVLN..SnnllpmdQ............W......G.....GG..G.....GP....................Q....QryanntpnQQGM..RQP.....NQLmqQN....IQQQQ.MLGipsnQ.LG...................VG....VG....V..GG
 2640- 2703 (61.03/13.42)	SV...............GTGQMPVVG..A.......G............VSMG..GG.....GA..AhgiglGA...P............IGAAT....S........GGGV..R.P.....PGA..QG....VGGGG.T........GG...................AG....PN....MVNGP
 2838- 2903 (59.93/12.99)	QNT..............AMMLPNLPP..G.......I............TNQG..GM.....VP..N.....QNwtkM............RYMQM....N........QYPP..PYP.....QRQ..RGphmgVAGQ.........P.QF...................P......G...GTTGNF
 2905- 2996 (49.79/ 8.98)	AGSagnvtgvqvagttvGSGAAGTVS..D.......Q............YSM...AN.....AA..A.....SN...MlqqqqtvggagvKPVPQ....Q........QQQQ..MGVippgmQQQ..PM....QQQQQ.QQM....M.QA...................VA....AG...G..GG.
 2997- 3065 (68.72/16.47)	.MT..............GTNPQNALP..G.......G............SS.G..PT.....GP..G.....SN...V............MGPPTphtlQ........QQLM..QTA.....RSS..PP....IRSPQpTPS....PrSA...................PS....PR...GPSASP
 3066- 3123 (43.45/ 6.47)	RAQ..............P.SPHHVMS..S.......H............S.PA..PQ.....GPhdG...lhNH...G............MHHQS....P..........................lPA....V..PQ.DVG....V.SG...................VS....VGvnaGNVGN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.75|      21|      23|    2300|    2322|       2
---------------------------------------------------------------------------
 2244- 2265 (32.37/16.49)	TRYHCTVCDDFDlCTV..C...KEKVG
 2305- 2330 (29.38/20.41)	SLVHACQCRDAN.CRLpsCqkmKRVVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.44|      17|      23|    2786|    2808|       4
---------------------------------------------------------------------------
 2779- 2795 (34.54/ 8.66)	QQQQ......QVM...QQQQMQHMMN
 2796- 2821 (21.90/12.65)	QQQQgpgpgpQQMgpgQQQQVSLMQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     122.47|      22|      23|     492|     513|       5
---------------------------------------------------------------------------
  470-  499 (22.89/10.69)	.LL...HAHKCNRRENmnpnrevCsvNY..CKAMKA
  500-  523 (33.93/20.13)	VLA...HMATCKQSKD.......CtmQH..CTSSRQ
  524-  536 (19.81/ 8.04)	ILL...HYKTC.QRSD.......C............
 2331- 2348 (21.31/ 9.33)	......HTKNCKRKTN............ggCPICKQ
 2350- 2374 (24.53/12.08)	IALccyHAKHC.QEQK.......CpvPF..CPNIK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     156.02|      23|      29|    1239|    1261|       6
---------------------------------------------------------------------------
 1239- 1261 (36.23/14.37)	P......TPTS.LDALTAGAPNAGAGGIGS
 1269- 1291 (35.66/14.00)	P......SPSF.MSNGPIGTPSNNPPSVSS
 1295- 1321 (24.56/ 6.84)	PlsnraaTPPY.IP..TSPVPATSASGLAA
 1323- 1345 (31.86/11.55)	S......TPAS.AAATCANSGSSSNISSTS
 1359- 1382 (27.72/ 8.88)	S......TPIScASGATQTSTTATSGNVNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.60|      23|      23|    1514|    1536|       8
---------------------------------------------------------------------------
 1445- 1478 (25.72/ 8.30)	G...GSSGGGGM....SSKGkLDsikqedeikkefMDDS..CG
 1479- 1506 (24.91/ 7.76)	G..nGDSSQMDCstggKGKN.VN............NDGTSMLK
 1514- 1535 (29.09/10.52)	....GAAGDVKI....KSEP.MD............VDESAVVG
 1536- 1560 (31.88/12.36)	GiatGANGDGGG....GSDG.KD.............DINGAID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     325.85|      61|      65|    1565|    1625|       9
---------------------------------------------------------------------------
 1565- 1611 (67.34/36.55)	............................GIA....SDIKIK.SETKP..MVPEPLAPNAGDKKKKCQFNPEEL.....RT...ALLPTLD
 1612- 1674 (79.68/44.70)	K..LYR.QEPESVPFRY....pvdpqalGIP....DYFEIV.K..KP..MDLGTIRNNILNGKYS...DPWEY.....VD...DVWLMFD
 1675- 1736 (62.88/33.60)	NawLYN.RKTSRV.YRY..............ctklSEV.FE.AEIDP...VMQALGYCCG...RKYTFNPQVLccygkQL...CTIPR.D
 1737- 1804 (64.97/34.99)	A..KYY.SYQNSLK.EYgvasnrytfcqKCF....ND..IQ.GDTVT..LGDDPLQSQTQIKKD..QF..KEM.....KNdhlELEPFVD
 1807- 1856 (50.98/25.74)	E..CGRkQHQICVLW..........................lDSIWPggFVCDNCLKKKNSKRKENKFNAKRL.....PT...TKL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.52|      19|      70|     197|     218|      10
---------------------------------------------------------------------------
  197-  217 (24.77/17.08)	LT....NSGGMGTIGGTGlVNTlKQ
  581-  603 (27.75/ 6.40)	QPqvsqNPSGVGVGVGVG.VDS.KQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.10|      19|      23|     840|     862|      11
---------------------------------------------------------------------------
  842-  862 (22.52/ 7.65)	SVlmPADTTGVANSSSSGSNS
  868-  886 (35.58/ 8.35)	GS..AGSAGGAGGAPGSGSDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.60|      13|     193|    2748|    2760|      13
---------------------------------------------------------------------------
  544-  556 (21.46/ 7.04)	QNHSLFQNASGAG
 2748- 2760 (23.81/ 8.82)	QQSQINAAAGGAG
 2945- 2954 (20.33/ 6.19)	QQQQ...TVGGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.62|      35|      60|     162|     196|      14
---------------------------------------------------------------------------
  162-  182 (26.57/ 6.93)	........................................MV.NSMPMSISNNGNNGMNAIP
  183-  243 (46.12/18.06)	GMNSIAQGNLGNMVltnsggmgtiggtglvntlkqpvaasLM.NAVPGSVGVSSVSGAAPSQ
 2536- 2562 (37.92/13.39)	GVGVPNQGAMGGMV............................gNQLTGNVGV..VPG.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.56|      27|      29|    2078|    2106|      16
---------------------------------------------------------------------------
 2078- 2106 (37.24/34.19)	D..QEEEEKRKQAEAAEAAAAANlfSAEDNE
 2110- 2138 (38.32/27.02)	DgkKKGQKKAKKSNKSKAAQRKN..SKKSNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.14|      28|      61|    1974|    2001|      17
---------------------------------------------------------------------------
 1974- 2001 (54.40/37.66)	ILLGYMDYVKQ.LGYTMAHIWACPPSEGD
 2036- 2064 (44.74/29.40)	IIQDYKDILKQaMEDKLGSAAELPYFEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.61|      10|    1813|     568|     577|      18
---------------------------------------------------------------------------
  568-  577 (19.68/ 8.60)	LQQQQQQQQL
 2382- 2391 (18.93/ 7.93)	LQQKLQQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.01|      11|      27|    2706|    2716|      20
---------------------------------------------------------------------------
 2706- 2716 (17.29/ 9.64)	NTQTLAQIMQK
 2736- 2746 (18.72/11.21)	NPQIMAAIIKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.84|      21|      27|     925|     947|      21
---------------------------------------------------------------------------
  904-  923 (29.36/15.06)	HKLVQ.AIF...PTSDPTTMQDKR.
  925-  946 (30.69/22.92)	HNLVSyAEK...VEKDMYEMAKSRS
  950-  971 (23.79/11.23)	HLL...AEKiykIQKELEEKRLKRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25198 with Med15 domain of Kingdom Metazoa
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