<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25194

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMAKMYGKGKTAIESEEQQKRRWQIELEFVQCLSNPNYLNFLAQRGYFKDPSFINYLKYLQYWKEPDYAKYLMYPMCLYFLDLLQYEHFRREIVNNQCCKFIDDQAILQWQHYTRKRIKLINSVQENAAAAAAAAAAAAAQQQQQQQQQQQSNGGSGILAPSEAATVAGIEAANPQQQATLQNGNSSAASTTQSQQQAREPAPTQTQVLSVSQQPQQQQQQQQQQQQQQQQQQQMNGLAASGAMKLELN
Length248
PositionMiddle
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.09
Grand average of hydropathy-0.817
Instability index73.13
Isoelectric point8.27
Molecular weight28220.16
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364129
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblMetazoa
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblMetazoa
GO - Biological Process
anterior/posterior axis specification, embryo	GO:0008595	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblMetazoa

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.49|      18|      77|     140|     163|       1
---------------------------------------------------------------------------
  140-  163 (25.69/16.69)	QQQQQQQQQQQSNgGSgilapSEA
  170-  187 (25.80/ 6.06)	EAANPQQQATLQN.GN.....SSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.49|      22|      28|      34|      61|       2
---------------------------------------------------------------------------
   34-   61 (32.33/39.64)	NPNYLNFLAqrgYfkdPSFINYLKYLQY
   64-   85 (44.17/30.79)	EPDYAKYLM...Y...PMCLYFLDLLQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.53|      17|      28|     192|     211|       3
---------------------------------------------------------------------------
  192-  208 (28.66/11.88)	QSQQQAREPAPTQTQVL
  221-  237 (32.87/ 8.74)	QQQQQQQQQQQQQMNGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25194 with Med31 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAATVAGIEAANPQQQATLQNGNSSAASTTQSQQQAREPAPTQTQVLSVSQQPQQQQQQQQQQQQQQQQQQQMNGLAASGAMKLELN
162
248










Molecular Recognition Features






MoRF SequenceStartStop




1) QTQVLSVSQQPQQQQ
2) SEAATVAGIE
204
161
218
170