<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25190

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAEEWQSQNFRQNVISKIHDMLPQNGPEPNKNASMMENHIFRKSHTKDEYLGLVAKLFMHYKDASQRKSQPQQQRQQQQQQQQQLQQQQQQQPAPSNAEMGQQNIMQDPLNALQNLASQGNRNPQLMPMGGAPGPNQMAGPGGPGTASNLLQTLNQQRPGQQQMQPMPNIRGQLPMGAGAGGQQMVQVQQMAGGNGPGGGAGGMQLNAMGPAVSQGQGQIVGNAGGMPNQMVGPGPNSGPTGGAAGGMPNQMSPMVMGMGNPMMRMNQGMQGMPSNMQQQQQHNVVGGPAGQQQVGGPGGLPPNAVQQGGGAMNPMAGMNVNMPPNMQQKPNMGMGQAGQMFAGNRGGVVGGQQQQPQQPFMRSSPSPADAQQLQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNTQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLGKISNDGTNVEKMTKMSKLLEILCNPTQRVQLDTLLKCEKALEKMDLVSYSGQQFGKSSNPLLEVINTTLQSPLANHTLHRTFRPSLELLFGTDICAPVPTKKPRLEEKTTPFEQDVPHVLQGEIARLDTKFKVKLDTTAQNNNKTIRLICCLDDKRLPSVPPVSVSVPEEYPWQSPDCSLTEQEYSATPFLQTVQQALIARMSKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAMCELSTLLGI
Length713
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.03
Grand average of hydropathy-0.719
Instability index65.30
Isoelectric point9.30
Molecular weight77534.63
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
ovarian follicle cell development	GO:0030707	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP25190
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     558.59|      78|      78|     205|     282|       1
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    7-   74 (49.45/ 9.15)	.......................S.QN....FRQnVISKIHDMLP....................QN.GPEPNKN.....ASMM........E..NHIfrkshtkdeylglvAKLFMHYKDA........SQRKSQPQQQ
  110-  184 (82.38/20.56)	............LNA...LQNLAS.QGnrnpQLM.PMGGAPG.PN....................QMAGPG...GP..GTASNLlqtlnqqrPgqQQM..............QPMPNIRGQL........PMGAGAGGQQ
  205-  272 (130.58/37.25)	...........QLNA...MGPAVS.QG....QGQ.IVGNAGGMPN....................QMVGPGPNSGPTGGAAGGM........P..NQM..............SPMVMGMGNP........MMRMNQGMQG
  273-  322 (83.34/20.89)	MPSNMQQQQQ.....hnvVGG..P.AG....QQQ..VGGPGGLP...........................PNAVQQGG..GAM...........N.........................P........MAGMN...VN
  323-  367 (70.14/16.31)	MPPNMQQKPNmGM.............G....Q.......AG........................QMF.....AGNRGGVVGG............QQQ..............QPQ.....QP........FMRSSPS...
  368-  416 (73.42/17.45)	.PADAQQLQQ.QL.....VG..................NQT..PT....................QQ.PPTPQM.PT...............P...QM............ipSPALVPQSSP........QM.M...MQN
  417-  512 (69.27/16.01)	TQRNIRQQ...........SPSASiNT....PGQ.VTGNSPFNPQeealyrekykqltkyieplkRMLGKISNDGTN...VEKM...........TKM..............SKLLEILCNPtqrvqldtLLKCEKALEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.40|      50|      77|     575|     624|       2
---------------------------------------------------------------------------
  529-  573 (36.97/18.30)	.....PLLEVINTTLQSPLANhtLHRTFRPS..LellfgtDICAPVPTKKPR........
  575-  624 (83.48/50.13)	EEKTTPFEQDVPHVLQGEIAR..LDTKFKVK..L......DTTAQNNNKTIRLICCLDDK
  653-  700 (71.95/42.24)	EYSATPFLQTVQQALIARMSK..LPKNYSLShlL......DTW....EMAVRQACSPQSK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25190 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HYKDASQRKSQPQQQRQQQQQQQQQLQQQQQQQPAPSNAEMGQQNIMQDPLNALQNLASQGNRNPQLMPMGGAPGPNQMAGPGGPGTASNLLQTLNQQRPGQQQMQPMPNIRGQLPMGAGAGGQQMVQVQQMAGGNGPGGGAGGMQLNAMGPAVSQGQGQIVGNAGGMPNQMVGPGPNSGPTGGAAGGMPNQMSPMVMGMGNPMMRMNQGMQGMPSNMQQQQQHNVVGGPAGQQQVGGPGGLPPNAVQQGGGAMNPMAGMNVNMPPNMQQKPNMGMGQAGQMFAGNRGGVVGGQQQQPQQPFMRSSPSPADAQQLQQQLVGNQTPTQQPPTPQMPTPQMIPSPALVPQSSPQMMMQNTQRNIRQQSPSASINTPGQVTGNSPFNPQEEAL
2) QNFRQNVISKIHDMLPQNGPEPNKNASMMENHIFRKSHTK
60
8
449
47










Molecular Recognition Features






MoRF SequenceStartStop




NANANA