<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP25189

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVESRREFGNGKDSSVFPHKVVLCAVSARNIIAFSALQSLSSHVYVCDIVTPWQYYKVCTSKSLINVLEWNASGEQLMLGYIGGRVEIWQPKEQALNVWQLHYHANIPSEDIIQAKFFHNGKGVAFNTQKKDHTYYAEKFERLEQRPTLTGFGGVATEGCILLSSSGLLAAFTLPQLHKLAPNSNSGVVPEPPLSGVSNEQIELTPATHSIGISRSYIEHSSIVPSASGALNIAYSIGWQQHQQLVHCFKVSLQLEGERIAIKSESLASIFLNTTPSPMESRRITQLLWTRVANEDVIYVVFGCADSASLLEQWTLTRRHQSVHALLQQSSAATANNSKPVDYVPSESWEQVAKLQLNAQISQLCSSRLNAADCEQLYAILQDNSVQVLEPGTLKQLNHTQFERDAEARFVCADLTPTSQMLLIFDSHAQLHAMQTPMLKQNASTMQLLLLLLEYCIVTGVDASDVLLLNLGNLEALVEKLTDNFTRQPSYVRQFYYANFLALKSNLCRAQQQEFDNLIILHAISSTFKSLLRPSDLGCQDKGPADNLAMKLAESVPDVDTVLLNLDPKDFTVEPMMLQSLQQLIQWVTDLALNMLNRLPEEVMKSKLSGKRASYDISRDIVAIGSLRELLVMIRIWGLLNPQCLPVYTKTMDNIDVLAILFRLLTRLAQNAAEPDELLLDECSLLSKQLLIPQPSKYNPTTLLSAQGYAAVKSGQLTFTSLVEPVGLQDIEMEQVVFANCVKDGVSNLQLGANPSTIRRCARCGFVNSANKVAKTSALKAWCNKWLHCHCGGFWKQIN
Length804
PositionTail
OrganismDrosophila virilis (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.07
Grand average of hydropathy-0.039
Instability index46.32
Isoelectric point6.27
Molecular weight89458.76
Publications
PubMed=17994087

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP25189
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     313.82|     100|     107|     205|     311|       1
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  205-  311 (151.23/128.21)	EQIELTPATHSIgisRSYIEHSSiVPSASGALNIAY..SIGWQQHQQLVHCFKVSlQLEGERI.AIKSESLASIFLNTTPSPMESRRITQLLWTRVaNEDViYVVFGCAD
  317-  419 (162.59/111.21)	EQWTLTRRHQSV...HALLQQSS.AATANNSKPVDYvpSESWEQVAKLQLNAQIS.QLCSSRLnAADCEQLYAILQDNSVQVLEPGTLKQLNHTQF.ERDA.EARFVCAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.37|      20|      72|     469|     488|       2
---------------------------------------------------------------------------
  469-  488 (30.39/16.46)	SDVLLLNLGNLEALVEKLTD
  540-  559 (32.44/17.99)	SDLGCQDKGPADNLAMKLAE
  564-  581 (24.55/12.09)	VDTVLLNLDPKDFTVEPM..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.64|      36|     516|     147|     187|       3
---------------------------------------------------------------------------
  147-  187 (56.41/41.74)	RLeqrptLTGFGGVATE.GCILLSSSGLLA.AFTLPQLHKLAP
  668-  705 (52.23/28.35)	RL.....LTRLAQNAAEpDELLLDECSLLSkQLLIPQPSKYNP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP25189 with Med16 domain of Kingdom Metazoa
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